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Showing 1 to 12 of 19 entries
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[Initial and terminal imputability of side effects (authors transl)].

Therapie

Dangoumau J, Begaud B, Pere JC, Albin H.
PMID: 7292395
Therapie. 1981 May-Jun;36(3):219-22.

No abstract available.

An overview of some pharmacological methods used in safety pharmacology studies.

Proceedings of the Western Pharmacology Society

Pugsley MK.
PMID: 15633602
Proc West Pharmacol Soc. 2004;47:18-22.

Safety Pharmacology is an integrated discipline that has evolved from the distinct fields of pharmacology, physiology and toxicology. Studies conducted under the guidance of 'Safety Pharmacology' are used to further the discovery, but more importantly, characterize the development of...

Deep mining heterogeneous networks of biomedical linked data to predict novel drug-target associations.

Bioinformatics (Oxford, England)

Zong N, Kim H, Ngo V, Harismendy O.
PMID: 28430977
Bioinformatics. 2017 Aug 01;33(15):2337-2344. doi: 10.1093/bioinformatics/btx160.

MOTIVATION: A heterogeneous network topology possessing abundant interactions between biomedical entities has yet to be utilized in similarity-based methods for predicting drug-target associations based on the array of varying features of drugs and their targets. Deep learning reveals features...

ICECAP: an integrated, general-purpose, automation-assisted IC50/EC50 assay platform.

Journal of laboratory automation

Li M, Chou J, King KW, Jing J, Wei D, Yang L.
PMID: 25524493
J Lab Autom. 2015 Feb;20(1):32-45. doi: 10.1177/2211068214562449. Epub 2014 Dec 18.

BACKGROUND: IC50 and EC50 values are commonly used to evaluate drug potency. Mass spectrometry (MS)-centric bioanalytical and biomarker labs are now conducting IC50/EC50 assays, which, if done manually, are tedious and error-prone. Existing bioanalytical sample preparation automation systems cannot...

On Becoming a Pharmacologist: Channeling David Triggle.

Biochemical pharmacology

Rampe D, Gopalakrishnan M.
PMID: 26254590
Biochem Pharmacol. 2015 Nov 15;98(2):292-8. doi: 10.1016/j.bcp.2015.08.002. Epub 2015 Aug 05.

This Festschrift contribution summarizes the perspectives of two of David Triggle's graduate students. Both share somewhat parallel scientific and career paths-i.e., enrolling in the Biochemical Pharmacology program at the University of Buffalo, pursuing graduate training under the mentorship of...

Comparison of problem-and lecture-based pharmacology teaching.

Trends in pharmacological sciences

Michel MC, Bischoff A, Jakobs KH.
PMID: 11931991
Trends Pharmacol Sci. 2002 Apr;23(4):168-70. doi: 10.1016/s0165-6147(00)01940-4.

Problem-based learning (PBL) is gaining interest in many medical schools. Although various approaches have been labelled PBL, it remains unclear which approach is most appropriate for pharmacology courses. Moreover, some teachers remain sceptical about whether PBL is adequate to...

Problem-based learning: the Maastricht experience.

Trends in pharmacological sciences

Struijker Boudier HA, Smits JF.
PMID: 11931989
Trends Pharmacol Sci. 2002 Apr;23(4):164. doi: 10.1016/s0165-6147(00)01980-5.

No abstract available.

Challenges facing pharmacology--the in vivo situation.

Trends in pharmacological sciences

Walker MJ, Soh ML.
PMID: 16480779
Trends Pharmacol Sci. 2006 Mar;27(3):125-6. doi: 10.1016/j.tips.2006.01.003. Epub 2006 Feb 15.

No abstract available.

The new wave in electronic laboratory notebook systems.

Chemical biology & drug design

Scoffin R.
PMID: 16492168
Chem Biol Drug Des. 2006 Feb;67(2):184-5. doi: 10.1111/j.1747-0285.2006.00355.x.

No abstract available.

Editors in Chief Overview.

Current opinion in pharmacology

Trist DG, Kenakin TP.
PMID: 29241830
Curr Opin Pharmacol. 2017 Aug;35:iv-v. doi: 10.1016/j.coph.2017.11.003.

No abstract available.

Chemoproteomics and Chemical Probes for Target Discovery.

Trends in biotechnology

Drewes G, Knapp S.
PMID: 30017093
Trends Biotechnol. 2018 Dec;36(12):1275-1286. doi: 10.1016/j.tibtech.2018.06.008. Epub 2018 Jul 13.

Chemical probes represent versatile tools to validate disease-modifying targets. However, evaluating the selectivity of chemical probes in complex cellular systems is a major challenge that needs to be addressed to better understand the mode of action of small molecules...

[Are principles of evidence-based medicine taken into account in the area of pharmacology?].

Zeitschrift fur arztliche Fortbildung und Qualitatssicherung

Lander T, Volmer T.
PMID: 10519190
Z Arztl Fortbild Qualitatssich. 1999 Aug;93(6):409-19.

Scientific literature published in the early 1980s claimed that only 15% of medical interventions are based on scientific evidence (57). Lately, a number of published articles concluded that ca. 80% of the interventions in family medicine (18, 25) and...

Showing 1 to 12 of 19 entries