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CRISPR/Cas9 genome editing in human pluripotent stem cells: Harnessing human genetics in a dish.

Developmental dynamics : an official publication of the American Association of Anatomists

González F.
PMID: 27145095
Dev Dyn. 2016 Jul;245(7):788-806. doi: 10.1002/dvdy.24414. Epub 2016 Jun 09.

Because of their extraordinary differentiation potential, human pluripotent stem cells (hPSCs) can differentiate into virtually any cell type of the human body, providing a powerful platform not only for generating relevant cell types useful for cell replacement therapies, but...

CRISPR/Cas9 facilitates genomic editing for large-scale functional studies in pluripotent stem cell cultures.

Human genetics

Li XF, Zhou YW, Cai PF, Fu WC, Wang JH, Chen JY, Yang QN.
PMID: 31606751
Hum Genet. 2019 Dec;138(11):1217-1225. doi: 10.1007/s00439-019-02071-z. Epub 2019 Oct 12.

Pluripotent stem cell (PSC) cultures form an integral part of biomedical and medical research due to their capacity to rapidly proliferate and differentiate into hundreds of highly specialized cell types. This makes them a highly useful tool in exploring...

Showing 1 to 2 of 2 entries