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Singh Y, Morimoto J, Shikata N, et al. Inhibitory Effect of the Angiogenesis Inhibitor O-(Chloroacetyl-carbamoyl)fumagillol(TNP-470) on Tumor Growth and Metastasis of Murine Mammary Tumor Cell Line (JYG-B)Inoculated in Female Nude Mice. Breast Cancer. 1996;3(2):105-110doi: 10.1007/BF02966970.
Singh, Y., Morimoto, J., Shikata, N., Uemura, Y., Hioki, K., & Tsubura, A. (1996). Inhibitory Effect of the Angiogenesis Inhibitor O-(Chloroacetyl-carbamoyl)fumagillol(TNP-470) on Tumor Growth and Metastasis of Murine Mammary Tumor Cell Line (JYG-B)Inoculated in Female Nude Mice. Breast cancer (Tokyo, Japan), 3(2), 105-110. https://doi.org/10.1007/BF02966970
Singh, et al. "Inhibitory Effect of the Angiogenesis Inhibitor O-(Chloroacetyl-carbamoyl)fumagillol(TNP-470) on Tumor Growth and Metastasis of Murine Mammary Tumor Cell Line (JYG-B)Inoculated in Female Nude Mice." Breast cancer (Tokyo, Japan) vol. 3,2 (1996): 105-110. doi: https://doi.org/10.1007/BF02966970
Singh Y, Morimoto J, Shikata N, Uemura Y, Hioki K, Tsubura A. Inhibitory Effect of the Angiogenesis Inhibitor O-(Chloroacetyl-carbamoyl)fumagillol(TNP-470) on Tumor Growth and Metastasis of Murine Mammary Tumor Cell Line (JYG-B)Inoculated in Female Nude Mice. Breast Cancer. 1996 Jun 28;3(2):105-110. doi: 10.1007/BF02966970. PMID: 11091561.
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Breast Cancer. 1996 Jun 28;3(2):105-110. doi: 10.1007/BF02966970.

Inhibitory Effect of the Angiogenesis Inhibitor O-(Chloroacetyl-carbamoyl)fumagillol(TNP-470) on Tumor Growth and Metastasis of Murine Mammary Tumor Cell Line (JYG-B)Inoculated in Female Nude Mice.

Breast cancer (Tokyo, Japan)

Singh, Morimoto, Shikata, Uemura, Hioki, Tsubura

Affiliations

  1. Departments of Pathology and Surgery, Kansai Medical University, 10-15 Fumizono, Moriguchi, Osaka 570-8507, Japan.

PMID: 11091561 DOI: 10.1007/BF02966970

Abstract

The effect of the potent angiogenesis inhibitor O-(chloroacetyl-carbamoyl) fumagillol(TNP-470), a semisynthetic analogue of fumagillin on tumor growth and metastasis was studied using murine mammary tumor cells (JYG-B) inoculated into female nude mice. Injection of TNP-470 at 10 and 30 mg/kg doses, 3 times a week, until the end of the experiment (41 days)inhibited the s.c.inoculated primary tumor growth in a dose-dependent manner (45%and 65% in volume, respectively). TNP-470 at 30 and 60 mg/kg doses, 3 times a week, until the end of the experiment (35 days), reduced the weight of the i.p. inoculated total tumor mass of abdominal dissemination in a dose-dependent manner (54% and 76%, respectively). Pulmonary metastasis was found in all mice but TNP-470 significantly reduced the lung weight reflecting the total volume of the metastatic foci, and the numbers of metastatic foci in the liver and kidneys was reduced by TNP-470 treatment. These findings show that the angiogenesis inhibitor (TNP-470)has a strong inhibitory effect on tumor grwoth and metastasis in vivo.

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