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Wu CC, Chen SJ, Yen MH. Attenuation of Endothelium-Dependent Relaxation in Mesenteric Artery during Noise-Induced Hypertension. J Biomed Sci. 1994;1(1):49-53doi: 10.1007/BF02258339.
Wu, C. C., Chen, S. J., & Yen, M. H. (1994). Attenuation of Endothelium-Dependent Relaxation in Mesenteric Artery during Noise-Induced Hypertension. Journal of biomedical science, 1(1), 49-53. https://doi.org/10.1007/BF02258339
Wu, C.C., et al. "Attenuation of Endothelium-Dependent Relaxation in Mesenteric Artery during Noise-Induced Hypertension." Journal of biomedical science vol. 1,1 (1994): 49-53. doi: https://doi.org/10.1007/BF02258339
Wu CC, Chen SJ, Yen MH. Attenuation of Endothelium-Dependent Relaxation in Mesenteric Artery during Noise-Induced Hypertension. J Biomed Sci. 1994 Dec;1(1):49-53. doi: 10.1007/BF02258339. PMID: 11725006.
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J Biomed Sci. 1994 Dec;1(1):49-53. doi: 10.1007/BF02258339.

Attenuation of Endothelium-Dependent Relaxation in Mesenteric Artery during Noise-Induced Hypertension.

Journal of biomedical science

C.C. Wu, S.J. Chen, M.H. Yen

Affiliations

  1. Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, ROC.

PMID: 11725006 DOI: 10.1007/BF02258339

Abstract

The present study was designed to determine whether there is a causal relationship between noise-induced hypertension and changes of endothelial function. Rats were exposed to noise stress (100 dB, 1 kHz, 4 h/day, 6 days/week) for 1-4 weeks. The systolic blood pressure was significantly increased after rats were exposed to noise stress for 3 weeks. The relaxant responses of isolated mesenteric arterial rings to endothelium-dependent vasodilators (A23187 and acetylcholine) in noise-treated rats were significantly less than those in control rats. This difference in response to acetylcholine still existed in the presence of methylene blue or N(omega)-nitro-L-arginine. On the other hand, the responses to the endothelium-dependent vasodilator nitroglycerin were not affected in rats exposed to noise stress. The attenuation to endothelium-dependent vasodilators during noise stress may result in increasing peripheral vascular resistance and thus elevate blood pressure. This indicates that noise-induced hypertension may be partly due to the alterations of endothelial activity. Copyright 1994 S. Karger AG, Basel

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