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Williams AE, Maskarinec G, Franke AA, et al. The temporal reliability of serum estrogens, progesterone, gonadotropins, SHBG and urinary estrogen and progesterone metabolites in premenopausal women. BMC Womens Health. 2002;2(1):13doi: 10.1186/1472-6874-2-13.
Williams, A. E., Maskarinec, G., Franke, A. A., & Stanczyk, F. Z. (2002). The temporal reliability of serum estrogens, progesterone, gonadotropins, SHBG and urinary estrogen and progesterone metabolites in premenopausal women. BMC women's health, 2(1), 13. https://doi.org/10.1186/1472-6874-2-13
Williams, Andrew E, et al. "The temporal reliability of serum estrogens, progesterone, gonadotropins, SHBG and urinary estrogen and progesterone metabolites in premenopausal women." BMC women's health vol. 2,1 (2002): 13. doi: https://doi.org/10.1186/1472-6874-2-13
Williams AE, Maskarinec G, Franke AA, Stanczyk FZ. The temporal reliability of serum estrogens, progesterone, gonadotropins, SHBG and urinary estrogen and progesterone metabolites in premenopausal women. BMC Womens Health. 2002 Dec 23;2(1):13. doi: 10.1186/1472-6874-2-13. PMID: 12498620; PMCID: PMC140038.
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BMC Womens Health. 2002 Dec 23;2(1):13. doi: 10.1186/1472-6874-2-13.

The temporal reliability of serum estrogens, progesterone, gonadotropins, SHBG and urinary estrogen and progesterone metabolites in premenopausal women.

BMC women's health

Andrew E Williams, Gertraud Maskarinec, Adrian A Franke, Frank Z Stanczyk

Affiliations

  1. Cancer Research Center of Hawaii, Honolulu, HI, USA. [email protected]

PMID: 12498620 PMCID: PMC140038 DOI: 10.1186/1472-6874-2-13

Abstract

BACKGROUND: There is little existing research to guide researchers in estimating the minimum number of measurement occasions required to obtain reliable estimates of serum estrogens, progesterone, gonadotropins, sex hormone-binding globulin (SHBG), and urinary estrogen and progesterone metabolites in premenopausal women. METHODS: Using data from a longitudinal study of 34 women with a mean age of 42.3 years (SD = 2.6), we calculated the minimum number of measurement occasions required to obtain reliable estimates of 12 analytes (8 in blood, 4 in urine). Five samples were obtained over 1 year: at baseline, and after 1, 3, 6, and 12 months. We also calculated the percent of true variance accounted for by a single measurement and intraclass correlation coefficients (ICC) between measurement occasions. RESULTS: Only 2 of the 12 analytes we examined, SHBG and estrone sulfate (E1S), could be adequately estimated by a single measurement using a minimum reliability standard of having the potential to account for 64% of true variance. Other analytes required from 2 to 12 occasions to account for 81% of the true variance, and 2 to 5 occasions to account for 64% of true variance. ICCs ranged from 0.33 for estradiol (E2) to 0.88 for SHBG. Percent of true variance accounted for by single measurements ranged from 29% for luteinizing hormone (LH) to 92% for SHBG. CONCLUSIONS: Experimental designs that take the natural variability of these analytes into account by obtaining measurements on a sufficient number of occasions will be rewarded with increased power and accuracy.

References

  1. Cancer Epidemiol Biomarkers Prev. 1996 Nov;5(11):917-22 - PubMed
  2. Clin Chem. 1991 Jun;37(6):838-44 - PubMed
  3. Am J Obstet Gynecol. 2000 Jan;182(1 Pt 1):23-9 - PubMed
  4. Cancer Epidemiol Biomarkers Prev. 1999 Jun;8(6):567-77 - PubMed
  5. Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1059-64 - PubMed
  6. Cancer Epidemiol Biomarkers Prev. 2002 Jan;11(1):147-51 - PubMed
  7. Endocr Pract. 2000 Jul-Aug;6(4):296-304 - PubMed
  8. Cancer Epidemiol Biomarkers Prev. 1996 Oct;5(10):835-44 - PubMed
  9. Epidemiology. 2000 Nov;11(6):635-40 - PubMed
  10. J Steroid Biochem. 1982 Jun;16(6):801-10 - PubMed
  11. Am J Clin Nutr. 1979 Dec;32(12):2546-59 - PubMed
  12. Int J Epidemiol. 1996 Dec;25(6):1107-16 - PubMed
  13. Psychol Bull. 1979 Mar;86(2):420-8 - PubMed
  14. Cancer Epidemiol Biomarkers Prev. 1994 Jan-Feb;3(1):47-50 - PubMed
  15. Cancer Epidemiol Biomarkers Prev. 1995 Jul-Aug;4(5):509-13 - PubMed
  16. Am J Clin Nutr. 1989 Jul;50(1):155-67 - PubMed
  17. Cancer Epidemiol Biomarkers Prev. 1994 Mar;3(2):149-53 - PubMed
  18. Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):81-7 - PubMed
  19. Cancer Epidemiol Biomarkers Prev. 2002 Feb;11(2):195-201 - PubMed
  20. Stat Med. 1999 Nov 15;18(21):2831-45 - PubMed
  21. J Obstet Gynecol Neonatal Nurs. 1992 Sep-Oct;21(5):407-11 - PubMed
  22. Stat Med. 1999 Nov 15;18(21):2815-29 - PubMed

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