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Cancer Radiother. 2003 Apr;7(2):79-89. doi: 10.1016/s1278-3218(02)00002-1.

[Volume-effect in radiation therapy part one: volume-effect and tumour].

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

[Article in French]
A Huchet, M Caudry, Y Belkacémi, R Trouette, V Vendrely, N Causse, L Récaldini, O Dahan, J Wu, J P Maire

Affiliations

  1. Service de radiothérapie, hôpital européen Georges-Pompidou (AP-HP), 20, rue Leblanc, 75908 cedex 15, Paris, France. [email protected]

PMID: 12719037 DOI: 10.1016/s1278-3218(02)00002-1

Abstract

Volume is an important parameter of radiation therapy. Local control is inversely related to tumor size and the complication rate increases with the importance of the irradiated volume. Although the effect of irradiated volume has been widely reported since the beginning of radiotherapy, it has been less studied than other radiation parameters such as dose, fractionation, or treatment duration. One of the first organ system in which the adverse effect of increased volume was well defined is the skin. Over the last twenty years, numerous mathematical models have been developed for different organs. In this report we will discuss the relation between irradiated volume and tumor control. In a second article we will study the impact of irradiated volume on radiation adverse effects.

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