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Hassanein T, Frederick T. Mitochondrial dysfunction in liver disease and organ transplantation. Mitochondrion. 2004;4(5):609-20doi: 10.1016/j.mito.2004.07.015.
Hassanein, T., & Frederick, T. (2004). Mitochondrial dysfunction in liver disease and organ transplantation. Mitochondrion, 4(5), 609-20. https://doi.org/10.1016/j.mito.2004.07.015
Hassanein, Tarek, and Frederick, Todd. "Mitochondrial dysfunction in liver disease and organ transplantation." Mitochondrion vol. 4,5 (2004): 609-20. doi: https://doi.org/10.1016/j.mito.2004.07.015
Hassanein T, Frederick T. Mitochondrial dysfunction in liver disease and organ transplantation. Mitochondrion. 2004 Sep;4(5):609-20. doi: 10.1016/j.mito.2004.07.015. PMID: 16120418.
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Mitochondrion. 2004 Sep;4(5):609-20. doi: 10.1016/j.mito.2004.07.015.

Mitochondrial dysfunction in liver disease and organ transplantation.

Mitochondrion

Tarek Hassanein, Todd Frederick

Affiliations

  1. Department of Medicine, UCSD School of Medicine, Hepatology, and Liver Transplant Service, San Diego, CA 92103, USA. [email protected]

PMID: 16120418 DOI: 10.1016/j.mito.2004.07.015

Abstract

The mitochondria play a crucial role in maintaining hepatocyte integrity and functions. Mitochondrial defects are either inherited or acquired. Mitochondria dysfunction occurs when the hepatocyte experience excessive physiologic stress. Its clinical presentation depends on the severity of the stress. It varies from mild abnormalities in liver biochemical tests to manifestations of acute or chronic liver failure. Mitochondria dysfunction is implicated in most liver disease and in early graft dysfunction after liver transplantation. This review will address the role of mitochondria in liver disease.

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