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Tamaki Y, Yoneda M, Sato K, et al. Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice. Hepatol Res. 2006;35(4):242-9doi: 10.1016/j.hepres.2006.05.002.
Tamaki, Y., Yoneda, M., Sato, K., Yokohama, S., Haneda, M., & Nakamura, K. (2006). Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice. Hepatology research : the official journal of the Japan Society of Hepatology, 35(4), 242-9. https://doi.org/10.1016/j.hepres.2006.05.002
Tamaki, Yosui, et al. "Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice." Hepatology research : the official journal of the Japan Society of Hepatology vol. 35,4 (2006): 242-9. doi: https://doi.org/10.1016/j.hepres.2006.05.002
Tamaki Y, Yoneda M, Sato K, Yokohama S, Haneda M, Nakamura K. Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice. Hepatol Res. 2006 Aug;35(4):242-9. doi: 10.1016/j.hepres.2006.05.002. Epub 2006 Jul 03. PMID: 16820320.
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Hepatol Res. 2006 Aug;35(4):242-9. doi: 10.1016/j.hepres.2006.05.002. Epub 2006 Jul 03.

Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice.

Hepatology research : the official journal of the Japan Society of Hepatology

Yosui Tamaki, Masashi Yoneda, Keisuke Sato, Shiro Yokohama, Masakazu Haneda, Kimihide Nakamura

Affiliations

  1. Second Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan.

PMID: 16820320 DOI: 10.1016/j.hepres.2006.05.002

Abstract

The intravenous injection of concanavalin A (Con A) activates T cells and induces cytokine dependent liver injury in mice. However, the effect of repeated administrations of Con A has not been fully investigated. Female BALB/c mice were intravenously injected with Con A (20mg/kg) or saline once a week for six times. Mice were rechallenged with Con A 17 days after repeated administrations of Con A. Repeated Con A administrations elicited a sustained inhibition of rechallenged-Con A-induced liver injury. Plasma TNF-alpha and IFN-gamma levels after rechallenge of Con A were decreased compared with that of repeated saline treatments. By contrast, plasma IL-4 and IL-10 levels after rechallenge of Con A were increased. In spleen cells prepared from repeated Con A treated mice, the production of TNF-alpha and IFN-gamma 24h after co-incubation with Con A decreased, and that of IL-4 and IL-10 increased. In naive mice, plasma ALT level after Con A injection was decreased by the transfer of spleen cells prepared from the repeated Con A treated mice. The repeated administrations of Con A elicited Th1 to Th2 cytokine shift and the tolerant state against the Con A-induced liver injury in mice.

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