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Animashaun A, Kelleher J, Heatley RV, et al. The effect of zinc and vitamin C supplementation on the immune status of patients with Crohn's disease. Clin Nutr. 1990;9(3):137-46doi: 10.1016/0261-5614(90)90045-t.
Animashaun, A., Kelleher, J., Heatley, R. V., Trejdosiewicz, L. K., & Losowsky, M. S. (1990). The effect of zinc and vitamin C supplementation on the immune status of patients with Crohn's disease. Clinical nutrition (Edinburgh, Scotland), 9(3), 137-46. https://doi.org/10.1016/0261-5614(90)90045-t
Animashaun, A, et al. "The effect of zinc and vitamin C supplementation on the immune status of patients with Crohn's disease." Clinical nutrition (Edinburgh, Scotland) vol. 9,3 (1990): 137-46. doi: https://doi.org/10.1016/0261-5614(90)90045-t
Animashaun A, Kelleher J, Heatley RV, Trejdosiewicz LK, Losowsky MS. The effect of zinc and vitamin C supplementation on the immune status of patients with Crohn's disease. Clin Nutr. 1990 Jun;9(3):137-46. doi: 10.1016/0261-5614(90)90045-t. PMID: 16837345.
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Clin Nutr. 1990 Jun;9(3):137-46. doi: 10.1016/0261-5614(90)90045-t.

The effect of zinc and vitamin C supplementation on the immune status of patients with Crohn's disease.

Clinical nutrition (Edinburgh, Scotland)

A Animashaun, J Kelleher, R V Heatley, L K Trejdosiewicz, M S Losowsky

Affiliations

  1. Department of Medicine, St. James's University Hospital, Leeds LS9 7TF, UK.

PMID: 16837345 DOI: 10.1016/0261-5614(90)90045-t

Abstract

The immune status of 29 patients with Crohn's disease given oral supplements of Vitamin C, zinc or placebo for three-week periods was studied. Collectively, the patients showed T-cell hyporesponsiveness, as assessed by phytohaemagglutinin stimulation, which was significantly improved by Vitamin C. Both monocyte function, as assessed by latex phagocytosis, and pan T-Cell number were significantly reduced and were not influenced by supplementation. Humoral immunity, assessed by pokeweed mitogen-induced immunoglobulin synthesis, was normal and remained unchanged. Vitamin C supplements improved T-cell function in Crohn's disease, whereas neither Vitamin C nor zinc had a measurable effect on humoral immunity.

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