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The human urothelial tight junction: claudin 3 and the ZO-1α.

Bladder (San Francisco, Calif.)

Smith NJ, Hinley J, Varley CL, Eardley I, Trejdosiewicz LK, Southgate J.
PMID: 26269793
Bladder (San Franc). 2015;2(1):e9. doi: 10.14440/bladder.2015.33.

OBJECTIVE: Tight junctions are multicomponent structures, with claudin proteins defining paracellular permeability. Claudin 3 is a candidate for the exceptional "tightness" of human urothelium, being localised to the terminal tight junction (TJ) of superficial cells. Our aim was to...

The effect of zinc and vitamin C supplementation on the immune status of patients with Crohn's disease.

Clinical nutrition (Edinburgh, Scotland)

Animashaun A, Kelleher J, Heatley RV, Trejdosiewicz LK, Losowsky MS.
PMID: 16837345
Clin Nutr. 1990 Jun;9(3):137-46. doi: 10.1016/0261-5614(90)90045-t.

The immune status of 29 patients with Crohn's disease given oral supplements of Vitamin C, zinc or placebo for three-week periods was studied. Collectively, the patients showed T-cell hyporesponsiveness, as assessed by phytohaemagglutinin stimulation, which was significantly improved by...

Urothelial cell transplantation using biodegradable synthetic scaffolds.

Journal of materials science. Materials in medicine

Scriven SD, Trejdosiewicz LK, Thomas DF, Southgate J.
PMID: 15348353
J Mater Sci Mater Med. 2001 Oct-Dec;12(10):991-6. doi: 10.1023/a:1012869318205.

Reconstruction of the urinary bladder with bowel to restore storage capacity is associated with significant complications arising from substituting an absorptive, mucus-producing intestinal epithelium for the barrier urothelium of the bladder. To overcome these problems, we are developing a...

Showing 1 to 3 of 3 entries