Indian Pacing Electrophysiol J. 2005 Jul 01;5(3):160-74.

Impact of a right ventricular impedance sensor on the cardiovascular responses to exercise in pacemaker dependent patients.

Indian pacing and electrophysiology journal

Linnea Cook, Corey Tomczak, Edward Busse, John Tsang, Wladyslaw Wojcik, Robert Haennel

PMID: 16943865 PMCID: PMC1431590

Abstract

BACKGROUND: The evaluation of the heart rate (HR) response to exercise is important for the assessment of the rate response algorithm of sensor-controlled pacemakers. This study examined the effects of a right ventricular impedance sensor driven pacemaker on the cardiovascular responses to incremental exercise in pacemaker dependent patients.

METHODS: Twelve patients (70.5 +/- 9.5 years; 5 Females: 7 Males) implanted with an Inos(2+) closed loop stimulation (CLS) pacemaker were compared to 12 healthy age and sex matched controls (70.6 +/- 4.8 years). All subjects performed the chronotropic assessment exercise protocol (CAEP). Variables of interest included HR, cardiac output (Q), oxygen uptake (VO2) and blood pressure (BP). Data were analyzed at rest, throughout exercise and during recovery. Furthermore, patient chronotropic responses were compared to a reference chronotropic response slope for aerobic exercise.

RESULTS: There were no differences between groups for HR or Q response throughout exercise. At peak exercise, VO2 (mL x kg(-1) x min(-1)) was higher for the controls (p < 0.05). The patient chronotropic response slope was comparable to the CAEP reference slope from rest to both the anaerobic threshold (AT) and peak exercise. During recovery, no differences were observed between the groups for any parameters or for the HR decay slopes.

CONCLUSION: Up to the anaerobic threshold, the right ventricular impedance sensor driven pacemaker delivered a pacing rate that contributed to an overall cardiovascular response similar to that observed in healthy age matched subjects.

References

1. Pacing Clin Electrophysiol. 1999 May;22(5):769-75 - PubMed
2. Pacing Clin Electrophysiol. 1998 Nov;21(11 Pt 2):2209-13 - PubMed
3. Pacing Clin Electrophysiol. 2000 Oct;23(10 Pt 1):1502-8 - PubMed
4. Pacing Clin Electrophysiol. 2000 Nov;23(11 Pt 2):1772-7 - PubMed
5. Pacing Clin Electrophysiol. 2001 Dec;24(12):1748-54 - PubMed
6. Pacing Clin Electrophysiol. 1992 Nov;15(11 Pt 2):1923-6 - PubMed
7. Pacing Clin Electrophysiol. 1992 Feb;15(2):211-8 - PubMed
8. Acta Physiol Scand Suppl. 1960;49(169):1-92 - PubMed
9. J Am Coll Cardiol. 1992 Dec;20(7):1533-41 - PubMed
10. Pacing Clin Electrophysiol. 1990 Oct;13(10):1277-85 - PubMed
11. Biomed Sci Instrum. 1990;26:137-40 - PubMed
12. Exerc Sport Sci Rev. 1989;17:231-63 - PubMed
13. J Appl Physiol (1985). 1986 Jun;60(6):2020-7 - PubMed
14. Crit Care Med. 1986 Oct;14(10):904-9 - PubMed
15. Am J Cardiol. 1986 Nov 1;58(10):891-5 - PubMed
16. Cardiovasc Res. 1985 Dec;19(12):737-43 - PubMed
17. J Appl Physiol Respir Environ Exerc Physiol. 1979 Oct;47(4):754-60 - PubMed
18. Eur J Appl Physiol Occup Physiol. 1994;69(2):132-9 - PubMed
19. Pacing Clin Electrophysiol. 1994 Nov;17(11 Pt 2):1920-7 - PubMed
20. Pacing Clin Electrophysiol. 1994 Dec;17(12 Pt 1):2307-14 - PubMed
21. Eur J Appl Physiol Occup Physiol. 1993;67(5):385-8 - PubMed
22. Med Sci Sports Exerc. 1997 Jun;29(6):762-8 - PubMed
23. Pacing Clin Electrophysiol. 1998 Apr;21(4 Pt 1):679-86 - PubMed
24. Pacing Clin Electrophysiol. 1998 Sep;21(9):1700-8 - PubMed
25. Pacing Clin Electrophysiol. 2000 Oct;23(10 Pt 1):1457-67 - PubMed

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