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Calin GA, Croce CM. MicroRNAs and chromosomal abnormalities in cancer cells. Oncogene. 2006;25(46):6202-10doi: 10.1038/sj.onc.1209910.
Calin, G. A., & Croce, C. M. (2006). MicroRNAs and chromosomal abnormalities in cancer cells. Oncogene, 25(46), 6202-10. https://doi.org/10.1038/sj.onc.1209910
Calin, G A, and Croce, C M. "MicroRNAs and chromosomal abnormalities in cancer cells." Oncogene vol. 25,46 (2006): 6202-10. doi: https://doi.org/10.1038/sj.onc.1209910
Calin GA, Croce CM. MicroRNAs and chromosomal abnormalities in cancer cells. Oncogene. 2006 Oct 09;25(46):6202-10. doi: 10.1038/sj.onc.1209910. PMID: 17028600.
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Oncogene. 2006 Oct 09;25(46):6202-10. doi: 10.1038/sj.onc.1209910.

MicroRNAs and chromosomal abnormalities in cancer cells.

Oncogene

G A Calin, C M Croce

Affiliations

  1. Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

PMID: 17028600 DOI: 10.1038/sj.onc.1209910

Abstract

Over the past five decades, a plethora of nonrandom chromosomal abnormalities have been consistently reported in malignant cells facilitating the identification of cancer-associated protein coding oncogenes and tumor suppressors. The genetic dissection of hot spots for chromosomal abnormalities in the age of the sequenced human genome resulted in the discovery that microRNA (miRNA) genes, encoding for a class of small noncoding RNAs, frequently resides in such genomic regions. The combination of nonrandom chromosomal abnormalities and other types of genetic alterations or epigenetic events contribute to downregulation or overexpression of miRNAs. The consequent abnormal expression of miRNAs affect cell cycle, survival and differentiation programs and selective targeting of these noncoding genes could provide novel therapeutic options for killing the malignant cells.

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