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Showing 1 to 12 of 195 entries
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MiRTargetLink--miRNAs, Genes and Interaction Networks.

International journal of molecular sciences

Hamberg M, Backes C, Fehlmann T, Hart M, Meder B, Meese E, Keller A.
PMID: 27089332
Int J Mol Sci. 2016 Apr 14;17(4):564. doi: 10.3390/ijms17040564.

Information on miRNA targeting genes is growing rapidly. For high-throughput experiments, but also for targeted analyses of few genes or miRNAs, easy analysis with concise representation of results facilitates the work of life scientists. We developed miRTargetLink, a tool...

miRQuest: integration of tools on a Web server for microRNA research.

Genetics and molecular research : GMR

Aguiar RR, Ambrosio LA, Sepúlveda-Hermosilla G, Maracaja-Coutinho V, Paschoal AR.
PMID: 27050998
Genet Mol Res. 2016 Mar 28;15(1). doi: 10.4238/gmr.15016861.

This report describes the miRQuest - a novel middleware available in a Web server that allows the end user to do the miRNA research in a user-friendly way. It is known that there are many prediction tools for microRNA...

MicroRNAs and triple negative breast cancer.

International journal of molecular sciences

D'Ippolito E, Iorio MV.
PMID: 24284394
Int J Mol Sci. 2013 Nov 11;14(11):22202-20. doi: 10.3390/ijms141122202.

Triple Negative Breast Cancer (TNBC) is a very aggressive tumor subtype, which still lacks specific markers for an effective targeted therapy. Despite the common feature of negativity for the three most relevant receptors (ER, PgR and HER2), TNBC is...

The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque.

Medical hypotheses

Jovanović I, Zivković M, Jovanović J, Djurić T, Stanković A.
PMID: 24815336
Med Hypotheses. 2014 Jul;83(1):11-5. doi: 10.1016/j.mehy.2014.04.019. Epub 2014 Apr 23.

MicroRNAs (miRs) are short, non-coding RNAs that regulate gene expression by absolute or partial binding to mRNA, which results in transcript degradation and translation blocking. Atherosclerosis, as a complex and progressive disease, represents one of the main causes of...

Computational and bioinformatics methods for microRNA gene prediction.

Methods in molecular biology (Clifton, N.J.)

Allmer J.
PMID: 24272436
Methods Mol Biol. 2014;1107:157-75. doi: 10.1007/978-1-62703-748-8_9.

MicroRNAs (miRNAs) have attracted ever-increasing interest in recent years. Since experimental approaches for determining miRNAs are nontrivial in their application, computational methods for the prediction of miRNAs have gained popularity. Such methods can be grouped into two broad categories...

A high-throughput microRNA expression profiling system.

Methods in molecular biology (Clifton, N.J.)

Guo Y, Mastriano S, Lu J.
PMID: 25030917
Methods Mol Biol. 2014;1176:33-44. doi: 10.1007/978-1-4939-0992-6_4.

As small noncoding RNAs, microRNAs (miRNAs) regulate diverse biological functions, including physiological and pathological processes. The expression and deregulation of miRNA levels contain rich information with diagnostic and prognostic relevance and can reflect pharmacological responses. The increasing interest in...

A miRNA-driven inference model to construct potential drug-disease associations for drug repositioning.

BioMed research international

Chen H, Zhang Z.
PMID: 25789319
Biomed Res Int. 2015;2015:406463. doi: 10.1155/2015/406463. Epub 2015 Feb 19.

Increasing evidence discovered that the inappropriate expression of microRNAs (miRNAs) will lead to many kinds of complex diseases and drugs can regulate the expression level of miRNAs. Therefore human diseases may be treated by targeting some specific miRNAs with...

OMIT: a domain-specific knowledge base for microRNA target prediction.

Pharmaceutical research

Huang J, Townsend C, Dou D, Liu H, Tan M.
PMID: 21879385
Pharm Res. 2011 Dec;28(12):3101-4. doi: 10.1007/s11095-011-0573-8. Epub 2011 Aug 31.

Identification and characterization of the important roles microRNAs (miRNAs) perform in human cancer is an increasingly active research area. Unfortunately, prediction of miRNA target genes remains a challenging task to cancer researchers. Current processes are time-consuming, error-prone, and subject...

MicroRNA expression profiling in cancer from a bioinformatics prospective.

Expert review of molecular diagnostics

Gusev Y, Brackett DJ.
PMID: 18020908
Expert Rev Mol Diagn. 2007 Nov;7(6):787-92. doi: 10.1586/14737159.7.6.787.

A new type of noncoding short single-stranded RNA molecules, microRNA (miRNA), has recently emerged as one of the most important new classes of cellular regulators. Recent advances in miRNA research have provided evidence that aberrant expression of specific miRNAs...

Potential clinical insights into microRNAs and their target genes in esophageal carcinoma.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Li SQ, Wang HM, Cao XF.
PMID: 21870994
Biomarkers. 2011 Dec;16(8):629-36. doi: 10.3109/1354750X.2011.608132. Epub 2011 Aug 29.

Esophageal carcinoma (EC) are characterized by dysregulation of microRNAs, which play an important roles as a posttranscriptional regulators in protein synthesis, and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. Recently, altered miRNAs expression has been...

MicroRNA changes in advanced radiotherapy techniques and its effect to secondary cancers.

Medical hypotheses

Sert F.
PMID: 22658362
Med Hypotheses. 2012 Sep;79(3):421-2. doi: 10.1016/j.mehy.2012.05.026. Epub 2012 Jun 01.

MicroRNAs (miRNAs) are a kind of RNA, produced copies of endogenous hairpin-shaped, are 21-25 nucleotide length, small, and single chain. Recent studies have revealed that hundreds of miRNAs are found in the human genome and are responsible for diverse...

A home-brew real-time PCR assay for reliable detection and quantification of mature miR-122.

Applied immunohistochemistry & molecular morphology : AIMM

Naderi M, Abdul Tehrani H, Soleimani M, Shabani I, Hashemi SM.
PMID: 25075470
Appl Immunohistochem Mol Morphol. 2015 Sep;23(8):601-6. doi: 10.1097/PAI.0000000000000125.

miR-122 is a liver-specific miRNA that has significant gene expression alterations in response to specific pathophysiological circumstances of liver such as drug-induced liver injury, hepatocellular carcinoma, and hepatitis B and C virus infections. Therefore, accurate and precise quantification of...

Showing 1 to 12 of 195 entries