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Li SQ, Wang HM, Cao XF. Potential clinical insights into microRNAs and their target genes in esophageal carcinoma. Biomarkers. 2011;16(8):629-36doi: 10.3109/1354750X.2011.608132.
Li, S. Q., Wang, H. M., & Cao, X. F. (2011). Potential clinical insights into microRNAs and their target genes in esophageal carcinoma. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 16(8), 629-36. https://doi.org/10.3109/1354750X.2011.608132
Li, Su Q, et al. "Potential clinical insights into microRNAs and their target genes in esophageal carcinoma." Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals vol. 16,8 (2011): 629-36. doi: https://doi.org/10.3109/1354750X.2011.608132
Li SQ, Wang HM, Cao XF. Potential clinical insights into microRNAs and their target genes in esophageal carcinoma. Biomarkers. 2011 Dec;16(8):629-36. doi: 10.3109/1354750X.2011.608132. Epub 2011 Aug 29. PMID: 21870994.
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Biomarkers. 2011 Dec;16(8):629-36. doi: 10.3109/1354750X.2011.608132. Epub 2011 Aug 29.

Potential clinical insights into microRNAs and their target genes in esophageal carcinoma.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Su Q Li, He M Wang, Xiu F Cao

Affiliations

  1. Department of Surgical Oncology, Affiliated Nanjing First Hospital of Nanjing Medical University and Oncology Center of Nanjing Medical University, Nanjing, Jiangsu Province, China.

PMID: 21870994 DOI: 10.3109/1354750X.2011.608132

Abstract

Esophageal carcinoma (EC) are characterized by dysregulation of microRNAs, which play an important roles as a posttranscriptional regulators in protein synthesis, and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. Recently, altered miRNAs expression has been comprehensively studied in EC by high-throughput technology. Increased understanding of miRNAs target genes and their potential regulatory mechanisms have clarified the miRNAs activities and may provide exciting opportunities for cancer diagnosis and miRNA-based genetherapy. Here, we reviewed the most recently discovered miRNA target genes, with particular emphasis on the deciphering of their possible mechanisms and the potential roles in miRNAs-based tumour therapeutics.

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