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Hamberg M, Backes C, Fehlmann T, et al. MiRTargetLink--miRNAs, Genes and Interaction Networks. Int J Mol Sci. 2016;17(4):564doi: 10.3390/ijms17040564.
Hamberg, M., Backes, C., Fehlmann, T., Hart, M., Meder, B., Meese, E., & Keller, A. (2016). MiRTargetLink--miRNAs, Genes and Interaction Networks. International journal of molecular sciences, 17(4), 564. https://doi.org/10.3390/ijms17040564
Hamberg, Maarten, et al. "MiRTargetLink--miRNAs, Genes and Interaction Networks." International journal of molecular sciences vol. 17,4 (2016): 564. doi: https://doi.org/10.3390/ijms17040564
Hamberg M, Backes C, Fehlmann T, Hart M, Meder B, Meese E, Keller A. MiRTargetLink--miRNAs, Genes and Interaction Networks. Int J Mol Sci. 2016 Apr 14;17(4):564. doi: 10.3390/ijms17040564. PMID: 27089332; PMCID: PMC4849020.
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Int J Mol Sci. 2016 Apr 14;17(4):564. doi: 10.3390/ijms17040564.

MiRTargetLink--miRNAs, Genes and Interaction Networks.

International journal of molecular sciences

Maarten Hamberg, Christina Backes, Tobias Fehlmann, Martin Hart, Benjamin Meder, Eckart Meese, Andreas Keller

Affiliations

  1. Chair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany. [email protected].
  2. Chair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany. [email protected].
  3. Chair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany. [email protected].
  4. Department of Human Genetics, Saarland University, Homburg D-66421, Germany. [email protected].
  5. Internal Medicine, Heidelberg University, Heidelberg D-69120, Germany. [email protected].
  6. Department of Human Genetics, Saarland University, Homburg D-66421, Germany. [email protected].
  7. Chair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany. [email protected].

PMID: 27089332 PMCID: PMC4849020 DOI: 10.3390/ijms17040564

Abstract

Information on miRNA targeting genes is growing rapidly. For high-throughput experiments, but also for targeted analyses of few genes or miRNAs, easy analysis with concise representation of results facilitates the work of life scientists. We developed miRTargetLink, a tool for automating respective analysis procedures that are frequently applied. Input of the web-based solution is either a single gene or single miRNA, but also sets of genes or miRNAs, can be entered. Validated and predicted targets are extracted from databases and an interaction network is presented. Users can select whether predicted targets, experimentally validated targets with strong or weak evidence, or combinations of those are considered. Central genes or miRNAs are highlighted and users can navigate through the network interactively. To discover the most relevant biochemical processes influenced by the target network, gene set analysis and miRNA set analysis are integrated. As a showcase for miRTargetLink, we analyze targets of five cardiac miRNAs. miRTargetLink is freely available without restrictions at www.ccb.uni-saarland.de/mirtargetlink.

Keywords: genes; interaction networks; miRNAs; miRTargetkLink

References

  1. Bioinformation. 2014 Sep 30;10(9):602-5 - PubMed
  2. Bioinformatics. 2011 Feb 1;27(3):431-2 - PubMed
  3. Nucleic Acids Res. 2015 Jan;43(Database issue):D447-52 - PubMed
  4. BMC Bioinformatics. 2012;13:36 - PubMed
  5. Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73 - PubMed
  6. Bioinformatics. 2016 May 15;32(10):1502-8 - PubMed
  7. Am J Physiol Heart Circ Physiol. 2015 Dec 1;309(11):H1813-26 - PubMed
  8. Mol Biosyst. 2014 Nov;10(11):2775-82 - PubMed
  9. Nucleic Acids Res. 2016 Jan 4;44(D1):D239-47 - PubMed
  10. Nucleic Acids Res. 2000 Sep 15;28(18):3442-4 - PubMed
  11. Minerva Cardioangiol. 2013 Dec;61(6):627-37 - PubMed
  12. J Transl Med. 2015;13:270 - PubMed
  13. Nucleic Acids Res. 2007 Jul;35(Web Server issue):W186-92 - PubMed
  14. Nucleic Acids Res. 2010 Jul;38(13):4476-86 - PubMed
  15. Nucleic Acids Res. 2015 Jul 1;43(W1):W283-8 - PubMed
  16. Genome Biol. 2003;5(1):R1 - PubMed

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