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Huang J, Townsend C, Dou D, et al. OMIT: a domain-specific knowledge base for microRNA target prediction. Pharm Res. 2011;28(12):3101-4doi: 10.1007/s11095-011-0573-8.
Huang, J., Townsend, C., Dou, D., Liu, H., & Tan, M. (2011). OMIT: a domain-specific knowledge base for microRNA target prediction. Pharmaceutical research, 28(12), 3101-4. https://doi.org/10.1007/s11095-011-0573-8
Huang, Jingshan, et al. "OMIT: a domain-specific knowledge base for microRNA target prediction." Pharmaceutical research vol. 28,12 (2011): 3101-4. doi: https://doi.org/10.1007/s11095-011-0573-8
Huang J, Townsend C, Dou D, Liu H, Tan M. OMIT: a domain-specific knowledge base for microRNA target prediction. Pharm Res. 2011 Dec;28(12):3101-4. doi: 10.1007/s11095-011-0573-8. Epub 2011 Aug 31. PMID: 21879385.
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Pharm Res. 2011 Dec;28(12):3101-4. doi: 10.1007/s11095-011-0573-8. Epub 2011 Aug 31.

OMIT: a domain-specific knowledge base for microRNA target prediction.

Pharmaceutical research

Jingshan Huang, Christopher Townsend, Dejing Dou, Haishan Liu, Ming Tan

Affiliations

  1. School of Computer and Information Sciences, University of South Alabama, 307 University Blvd. N, Mobile, Alabama, USA. [email protected]

PMID: 21879385 DOI: 10.1007/s11095-011-0573-8

Abstract

Identification and characterization of the important roles microRNAs (miRNAs) perform in human cancer is an increasingly active research area. Unfortunately, prediction of miRNA target genes remains a challenging task to cancer researchers. Current processes are time-consuming, error-prone, and subject to biologists' limited prior knowledge. Therefore, we propose a domain-specific knowledge base built upon Ontology for MicroRNA Targets (OMIT) to facilitate knowledge acquisition in miRNA target gene prediction. We describe the ontology design, semantic annotation and data integration, and user-friendly interface and conclude that the OMIT system can assist biologists in unraveling the important roles of miRNAs in human cancer. Thus, it will help clinicians make sound decisions when treating cancer patients.

References

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  3. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1949-54 - PubMed
  4. J Biol Chem. 2010 Jul 9;285(28):21496-507 - PubMed

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