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Li Y, Niu W, Lu J. Sensitive determination of phenothiazines in pharmaceutical preparation and biological fluid by flow injection chemiluminescence method using luminol-KMnO(4) system. Talanta. 2006;71(3):1124-9doi: 10.1016/j.talanta.2006.06.007.
Li, Y., Niu, W., & Lu, J. (2007). Sensitive determination of phenothiazines in pharmaceutical preparation and biological fluid by flow injection chemiluminescence method using luminol-KMnO(4) system. Talanta, 71(3), 1124-9. https://doi.org/10.1016/j.talanta.2006.06.007
Li, Yinhuan, et al. "Sensitive determination of phenothiazines in pharmaceutical preparation and biological fluid by flow injection chemiluminescence method using luminol-KMnO(4) system." Talanta vol. 71,3 (2007): 1124-9. doi: https://doi.org/10.1016/j.talanta.2006.06.007
Li Y, Niu W, Lu J. Sensitive determination of phenothiazines in pharmaceutical preparation and biological fluid by flow injection chemiluminescence method using luminol-KMnO(4) system. Talanta. 2007 Feb 28;71(3):1124-9. doi: 10.1016/j.talanta.2006.06.007. Epub 2006 Jul 17. PMID: 19071422.
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Talanta. 2007 Feb 28;71(3):1124-9. doi: 10.1016/j.talanta.2006.06.007. Epub 2006 Jul 17.

Sensitive determination of phenothiazines in pharmaceutical preparation and biological fluid by flow injection chemiluminescence method using luminol-KMnO(4) system.

Talanta

Yinhuan Li, Weifen Niu, Jiuru Lu

Affiliations

  1. School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, China; School of Science, Xi'an Jiaotong University, Xi'an 710049, China.

PMID: 19071422 DOI: 10.1016/j.talanta.2006.06.007

Abstract

A flow injection chemiluminescence method was described for the determination of four phenothiazine drugs, namely, chlorpromazine hydrochloride, perphenazine hydrochloride, fluphenazine hydrochloride and thioridazine hydrochloride. Strong Chemiluminescence (CL) signal was produced when above-mentioned drug was injected into the mixed stream of luminol with KMnO(4). The linear ranges of the method were 0.0020-1.0mug/mL chlorpromazine hydrochloride, 0.0040-3.0mug/mL perphenazine hydrochloride, 0.0020-5.0mug/mL fluphenazine hydrochloride and 0.0050-1.0mug/mL thioridazine hydrochloride. The detection limits were 0.4ng/mL chlorpromazine hydrochloride, 0.7ng/mL perphenazine hydrochloride, 2ng/mL fluphenazine hydrochloride and 0.7ng/mL thioridazine hydrochloride. The proposed method was applied to the determination of chlorpromazine hydrochloride in injections and in mental patient's urine samples and the satisfactory results were achieved. The possible CL reaction mechanism was also discussed briefly.

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