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Zhao Y, Zhai D, He H, et al. Matrine improves 17alpha-ethinyl estradiol-induced acute cholestasis in rats. Hepatol Res. 2009;39(11):1144-9doi: 10.1111/j.1872-034X.2009.00557.x.
Zhao, Y., Zhai, D., He, H., Liu, J., Li, T., Chen, X., & Ji, H. (2009). Matrine improves 17alpha-ethinyl estradiol-induced acute cholestasis in rats. Hepatology research : the official journal of the Japan Society of Hepatology, 39(11), 1144-9. https://doi.org/10.1111/j.1872-034X.2009.00557.x
Zhao, Ying, et al. "Matrine improves 17alpha-ethinyl estradiol-induced acute cholestasis in rats." Hepatology research : the official journal of the Japan Society of Hepatology vol. 39,11 (2009): 1144-9. doi: https://doi.org/10.1111/j.1872-034X.2009.00557.x
Zhao Y, Zhai D, He H, Liu J, Li T, Chen X, Ji H. Matrine improves 17alpha-ethinyl estradiol-induced acute cholestasis in rats. Hepatol Res. 2009 Nov;39(11):1144-9. doi: 10.1111/j.1872-034X.2009.00557.x. Epub 2009 Jul 10. PMID: 19619254.
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Hepatol Res. 2009 Nov;39(11):1144-9. doi: 10.1111/j.1872-034X.2009.00557.x. Epub 2009 Jul 10.

Matrine improves 17alpha-ethinyl estradiol-induced acute cholestasis in rats.

Hepatology research : the official journal of the Japan Society of Hepatology

Ying Zhao, Desheng Zhai, Hui He, Junhua Liu, Tingting Li, Xijing Chen, Hui Ji

Affiliations

  1. School of Pharmacy, China Pharmaceutical University, Nanjing, China.

PMID: 19619254 DOI: 10.1111/j.1872-034X.2009.00557.x

Abstract

AIM: To explore the effects of matrine (MT) on acute intrahepatic cholestasis induced by 17alpha-ethinyl estradiol (EE) in rats.

METHODS: Acute intrahepatic cholestasis in rats were induced by EE, and the effects of MT on acute intrahepatic cholestasis were explored and compared with ursodeoxycholic acid (UDCA) by serum biochemical determination and bile excretion experiments.

RESULTS: The serum biochemical and bile biochemical results indicated that MT and UDCA had notable hepatoprotective effects by counteracting cholestasis induced by EE. The bile flow and the bile excretion of glycocholic acid (GC, a substrate of bile salt export pump [Bsep]), ketoprofen glucuronide (KPG) and rhodamine 123 (Rh123, a substrate of multidrug resistance protein 1 [MDR1]) decreased by EE, were significantly improved after administration of MT.

CONCLUSION: MT exhibited potential protection against EE-induced acute intrahepatic cholestasis.

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