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Shojaie M, Sotoodah A, Roozmeh S, et al. Annexin V and anti-Annexin V antibodies: two interesting aspects in acute myocardial infarction. Thromb J. 2009;7:13doi: 10.1186/1477-9560-7-13.
Shojaie, M., Sotoodah, A., Roozmeh, S., Kholoosi, E., & Dana, S. (2009). Annexin V and anti-Annexin V antibodies: two interesting aspects in acute myocardial infarction. Thrombosis journal, 713. https://doi.org/10.1186/1477-9560-7-13
Shojaie, Mohammad, et al. "Annexin V and anti-Annexin V antibodies: two interesting aspects in acute myocardial infarction." Thrombosis journal vol. 7 (2009): 13. doi: https://doi.org/10.1186/1477-9560-7-13
Shojaie M, Sotoodah A, Roozmeh S, Kholoosi E, Dana S. Annexin V and anti-Annexin V antibodies: two interesting aspects in acute myocardial infarction. Thromb J. 2009 Jul 21;7:13. doi: 10.1186/1477-9560-7-13. PMID: 19622170; PMCID: PMC2724414.
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Thromb J. 2009 Jul 21;7:13. doi: 10.1186/1477-9560-7-13.

Annexin V and anti-Annexin V antibodies: two interesting aspects in acute myocardial infarction.

Thrombosis journal

Mohammad Shojaie, Abdoreza Sotoodah, Shohre Roozmeh, Ensieh Kholoosi, Samira Dana

Affiliations

  1. Department of Cardiology, Jahrom University of Medical science, Jahrom, Iran. [email protected].

PMID: 19622170 PMCID: PMC2724414 DOI: 10.1186/1477-9560-7-13

Abstract

BACKGROUND: Myocardial infarction is the combined result of environmental factors and personal predispositions. Prothrombotic factors might play an important role in this phenomenon. Annexin V (ANV) is a calcium-dependent glycoprotein widely present in various tissues exerting a potent anticoagulant effect in vitro by reducing plaque adhesion and aggregation. Anti-annexin V antibodies (aANVAs) are detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study of ANV in Acute Myocardial Infarction (AMI) might shed light on hypercoagulability mechanisms in the pathogenesis of acute coronary syndromes. This study was conducted to investigate the association of plasma ANV, aANVAs and anti-cardiolipin antibodies (aCLAs) with AMI.

METHODS: This study recruited 45 patients with the diagnosis of AMI according to WHO criteria in their first 24 hours of admission. 36 matched individuals were studied as the control group with normal coronary artery angiography. Plasma levels of ANV, aANVAs and aCLAs were determined by enzyme-linked immunosorbent assay and the results were compared.

RESULTS: Plasma ANV levels in the patients with AMI on admission were significantly lower than those in the control group (p = 0.002). Positive test for aANVAs were found to be present in a significant number of our patients (p = 0.004). The studied groups were similar in their rate of patients with positive aCLAs tests. ANV, aANVAs and aCLAs were not correlated with hypertension, diabetes mellitus, hyperlipidemia, sex, age and smoking.

CONCLUSION: Our findings suggest that low plasma ANV levels along with positive aANVAs tests in patients with AMI are indicative of hypercoagulable state that is not related to the traditional cardiovascular risk factors.

References

  1. Autoimmun Rev. 2005 Jan;4(1):55-60 - PubMed
  2. Cell Mol Life Sci. 1997 Jun;53(6):527-32 - PubMed
  3. Thromb Haemost. 1995 Feb;73(2):172-9 - PubMed
  4. Lancet. 1993 Aug 7;342(8867):341-4 - PubMed
  5. Am J Hematol. 1997 Mar;54(3):209-13 - PubMed
  6. Thromb Haemost. 2001 Jul;86(1):413-9 - PubMed
  7. Ann Rheum Dis. 2003 Feb;62(2):188-9 - PubMed
  8. Rev Esp Cardiol. 2002 Dec;55(12):1230-4 - PubMed
  9. J Rheumatol. 2000 Apr;27(4):924-9 - PubMed
  10. Blood. 2004 Nov 1;104(9):2783-90 - PubMed
  11. Circulation. 1997 Oct 7;96(7):2339-47 - PubMed
  12. Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):198-203 - PubMed
  13. N Engl J Med. 1995 Mar 9;332(10):635-41 - PubMed
  14. N Engl J Med. 1997 Jul 17;337(3):154-60 - PubMed
  15. Am J Clin Pathol. 2000 Oct;114(4):619-28 - PubMed
  16. N Engl J Med. 1999 Apr 1;340(13):1035-6 - PubMed
  17. Thromb Haemost. 1999 Aug;82(2):649-55 - PubMed
  18. Eur Heart J. 2002 Jan;23(1):88 - PubMed
  19. J Am Soc Echocardiogr. 2005 Dec;18(12):1440-63 - PubMed
  20. Rev Esp Cardiol. 2002 Dec;55(12):1223-5 - PubMed
  21. Ann Rheum Dis. 1996 Dec;55(12):895-900 - PubMed
  22. Resuscitation. 2003 May;57(2):171-7 - PubMed
  23. Clin Chim Acta. 1996 Jul 15;251(1):65-80 - PubMed
  24. Circulation. 1995 Nov 15;92(10):3113-21 - PubMed
  25. Blood. 1998 Sep 1;92(5):1652-60 - PubMed
  26. Thromb Haemost. 1993 Mar 1;69(3):227-30 - PubMed
  27. Heart. 1998 Oct;80(4):334-7 - PubMed
  28. J Am Coll Cardiol. 1995 Sep;26(3):654-61 - PubMed
  29. Rheumatology (Oxford). 2007 Jan;46(1):81-6 - PubMed
  30. Arterioscler Thromb. 1994 May;14(5):824-30 - PubMed
  31. Biochem Biophys Res Commun. 1994 Dec 15;205(2):1488-93 - PubMed
  32. J Rheumatol. 1999 Oct;26(10):2168-72 - PubMed
  33. Physiol Rev. 2002 Apr;82(2):331-71 - PubMed

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