Display options
Share it on

Future Cardiol. 2008 Mar;4(2):163-74. doi: 10.2217/14796678.4.2.163.

Role of fetal programming in the development of hypertension.

Future cardiology

Norma B Ojeda, Daniela Grigore, Barbara T Alexander

Affiliations

  1. University of Mississippi Medical Center, Department of Physiology & Biophysics, The Center for Excellence in Cardiovascular-Renal Research, 2500 North State Street, Jackson, MS 39216-4505, USA. [email protected]

PMID: 19672482 PMCID: PMC2723856 DOI: 10.2217/14796678.4.2.163

Abstract

Epidemiological studies have suggested that size at birth contributes to increased cardiovascular disease (CVD) risk in later life. Findings from experimental studies are providing insight into the mechanisms linking impaired fetal growth and the increased risk of CVD and hypertension in adulthood. This article summarizes potential mechanisms involved in the fetal programming of hypertension and CVD, including alterations in the organs and regulatory systems critical to long-term control of sodium and volume homeostasis.

Keywords: glucocorticoids; kidney; renin-angiotensin system; sex hormones; sympathetic nervous system; vascular function

References

  1. Brain Res Dev Brain Res. 1995 Jan 14;84(1):55-61 - PubMed
  2. Am J Physiol Regul Integr Comp Physiol. 2006 Oct;291(4):R1060-8 - PubMed
  3. BMJ. 2001 Apr 14;322(7291):912-6 - PubMed
  4. J Physiol. 2007 Apr 15;580(Pt. 2):639-48 - PubMed
  5. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1837-41 - PubMed
  6. J Am Soc Nephrol. 2005 Sep;16(9):2545-56 - PubMed
  7. Am J Obstet Gynecol. 2007 May;196(5):477.e1-7 - PubMed
  8. Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R695-700 - PubMed
  9. Contraception. 1999 Mar;59(3):203-7 - PubMed
  10. Endocrinology. 2002 Nov;143(11):4455-63 - PubMed
  11. J Hypertens. 2000 Feb;18(2):123-37 - PubMed
  12. Endocrinology. 2001 Jul;142(7):2841-53 - PubMed
  13. Hypertension. 1999 Jan;33(1 Pt 2):323-8 - PubMed
  14. Pediatrics. 2007 Jun;119(6):e1264-70 - PubMed
  15. Circulation. 2002 Mar 5;105(9):1088-92 - PubMed
  16. Physiol Rev. 2005 Apr;85(2):571-633 - PubMed
  17. Kidney Int. 2005 Mar;67(3):822-8 - PubMed
  18. J Endocrinol. 2006 Mar;188(3):435-42 - PubMed
  19. Int J Epidemiol. 1991 Dec;20(4):833-44 - PubMed
  20. Am J Reprod Immunol. 2005 Aug;54(2):63-9 - PubMed
  21. BMJ. 1998 Jul 18;317(7152):167-71 - PubMed
  22. Kidney Int. 2005 Nov;68(5):2180-8 - PubMed
  23. Diabet Med. 2000 Dec;17(12):848-53 - PubMed
  24. J Dev Physiol. 1983 Apr;5(2):77-87 - PubMed
  25. Lancet. 1989 Sep 9;2(8663):577-80 - PubMed
  26. Circulation. 2003 Aug 5;108(5):566-71 - PubMed
  27. FASEB J. 2006 Jun;20(8):1251-3 - PubMed
  28. Endocr Res. 2004 Nov;30(4):827-36 - PubMed
  29. Life Sci. 2007 Jan 30;80(8):782-7 - PubMed
  30. Hypertension. 2003 Feb;41(2):328-34 - PubMed
  31. J Comp Pathol. 1977 Oct;87(4):629-33 - PubMed
  32. Am J Obstet Gynecol. 2003 Nov;189(5):1467-71 - PubMed
  33. N Engl J Med. 1990 Jul 5;323(1):22-7 - PubMed
  34. J Physiol. 2005 May 15;565(Pt 1):125-35 - PubMed
  35. Semin Neonatol. 2001 Aug;6(4):319-29 - PubMed
  36. Am J Epidemiol. 2007 Sep 15;166(6):634-45 - PubMed
  37. J Physiol. 2003 Feb 15;547(Pt 1):61-6 - PubMed
  38. Clin Sci (Lond). 2003 Jun;104(6):607-14 - PubMed
  39. Life Sci. 1999;64(11):965-74 - PubMed
  40. Diabet Med. 1997 Aug;14(8):673-7 - PubMed
  41. Circulation. 2000 Dec 5;102(23):2892-7 - PubMed
  42. J Physiol. 2005 May 15;565(Pt 1):197-205 - PubMed
  43. Am J Obstet Gynecol. 2005 Apr;192(4):1196-204 - PubMed
  44. Life Sci. 1997;60(15):1213-21 - PubMed
  45. Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1236-45 - PubMed
  46. J Soc Gynecol Investig. 2003 Dec;10(8):469-73 - PubMed
  47. Prague Med Rep. 2004;105(3):291-300 - PubMed
  48. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R758-63 - PubMed
  49. Hypertension. 2003 Jan;41(1):168-75 - PubMed
  50. J Physiol. 2005 May 15;565(Pt 1):137-47 - PubMed
  51. J Physiol. 2003 Jun 15;549(Pt 3):929-35 - PubMed
  52. J Am Soc Nephrol. 1999 Apr;10 Suppl 12:S258-65 - PubMed
  53. J Cardiovasc Pharmacol. 2002 Oct;40(4):501-9 - PubMed
  54. Hypertension. 1992 May;19(5):456-63 - PubMed
  55. Hypertension. 2008 Feb;51(2):383-92 - PubMed
  56. Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1212-6 - PubMed
  57. Int J Epidemiol. 2002 Apr;31(2):302-8 - PubMed
  58. Hypertension. 2003 Mar;41(3):457-62 - PubMed
  59. Stroke. 2002 Dec;33(12):2992-8 - PubMed
  60. J Vasc Res. 2001 Jan-Feb;38(1):1-12 - PubMed
  61. Placenta. 1996 Mar-Apr;17(2-3):169-72 - PubMed
  62. Br J Nutr. 2000 Jan;83(1):79-85 - PubMed
  63. J Soc Gynecol Investig. 2005 Jan;12(1):2-13 - PubMed
  64. Lancet. 2002 Aug 31;360(9334):659-65 - PubMed
  65. Exp Physiol. 2000 Jan;85(1):79-84 - PubMed
  66. Br J Nutr. 2007 Jul;98(1):93-100 - PubMed
  67. J Intern Med. 2005 Jun;257(6):496-502 - PubMed
  68. Am J Physiol. 1997 Dec;273(6):R1908-15 - PubMed
  69. Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1943-55 - PubMed
  70. Asia Oceania J Obstet Gynaecol. 1991 Dec;17(4):341-8 - PubMed
  71. Pediatr Nephrol. 1994 Apr;8(2):175-80 - PubMed
  72. Curr Opin Pharmacol. 2002 Apr;2(2):121-5 - PubMed
  73. Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R962-70 - PubMed
  74. Hypertension. 2005 Apr;45(4):754-8 - PubMed
  75. Acta Physiol Scand. 2004 Aug;181(4):537-42 - PubMed
  76. Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1608-15 - PubMed
  77. Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R46-53 - PubMed
  78. Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R1131-6 - PubMed
  79. Am J Med. 1972 May;52(5):584-94 - PubMed
  80. Kidney Int. 2004 Apr;65(4):1339-48 - PubMed
  81. Pediatr Nephrol. 2001 May;16(5):417-22 - PubMed
  82. Endocrinology. 2003 Jul;144(7):2933-40 - PubMed
  83. Am J Physiol. 1998 Nov;275(5):R1593-9 - PubMed
  84. Hypertension. 2007 Oct;50(4):679-85 - PubMed
  85. Am J Physiol Regul Integr Comp Physiol. 2006 Aug;291(2):R429-36 - PubMed
  86. Psychoneuroendocrinology. 2007 Aug;32 Suppl 1:S16-20 - PubMed
  87. Hypertension. 2007 Jun;49(6):1429-35 - PubMed
  88. Hypertension. 2001 Sep;38(3):337-42 - PubMed
  89. J Hypertens. 2004 Jun;22(6):1157-63 - PubMed
  90. Kidney Int. 2003 Jun;63(6):2113-22 - PubMed
  91. Clin Exp Pharmacol Physiol. 2001 Apr;28(4):306-11 - PubMed
  92. Bioessays. 2003 Mar;25(3):212-20 - PubMed
  93. J Physiol. 2007 Feb 1;578(Pt 3):871-81 - PubMed
  94. Psychoneuroendocrinology. 1998 Aug;23(6):571-81 - PubMed
  95. Pediatr Res. 2005 Jun;57(6):796-800 - PubMed
  96. Clin Exp Pharmacol Physiol. 2001 Nov;28(11):938-41 - PubMed
  97. Brain Res Rev. 2008 Mar;57(2):586-95 - PubMed
  98. Hypertension. 2003 Oct;42(4):768-74 - PubMed
  99. Hypertension. 2002 Nov;40(5):729-34 - PubMed
  100. Pediatr Nephrol. 2002 Oct;17(10):856-62 - PubMed
  101. Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R306-13 - PubMed
  102. J Clin Endocrinol Metab. 2001 Oct;86(10):4979-83 - PubMed
  103. Circulation. 2002 Jun 11;105(23):2791-6 - PubMed
  104. Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R804-11 - PubMed
  105. J Clin Endocrinol Metab. 2002 Aug;87(8):3696-701 - PubMed
  106. BMJ. 1997 Feb 15;314(7079):475-80 - PubMed
  107. Circulation. 2007 Feb 6;115(5):e69-171 - PubMed
  108. J Physiol. 2007 Mar 1;579(Pt 2):503-13 - PubMed
  109. Pediatr Res. 2001 Apr;49(4):460-7 - PubMed
  110. Endocrinology. 2004 Feb;145(2):790-8 - PubMed
  111. BMJ. 1988 Jul 9;297(6641):134-5 - PubMed
  112. Am J Obstet Gynecol. 2007 Jun;196(6):555.e1-7 - PubMed
  113. Lancet. 1993 Feb 6;341(8841):339-41 - PubMed
  114. Circulation. 2000 Nov 28;102(22):2739-44 - PubMed
  115. Hypertension. 2006 Oct;48(4):717-23 - PubMed
  116. ILAR J. 2006;47(1):73-82 - PubMed
  117. Cell Mol Life Sci. 2004 Nov;61(21):2720-7 - PubMed
  118. Pediatr Res. 2006 Jul;60(1):83-7 - PubMed
  119. Hypertension. 2002 Jun;39(6):1071-6 - PubMed
  120. Obesity (Silver Spring). 2006 Aug;14(8):1330-43 - PubMed
  121. Am J Physiol Regul Integr Comp Physiol. 2004 Jul;287(1):R12-20 - PubMed

Publication Types

Grant support