Display options
Cite
Lubiński J, Huzarski T, Kurzawski G, et al. The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs. Hered Cancer Clin Pract. 2005;3(2):59-63doi: 10.1186/1897-4287-3-2-59.
Lubiński, J., Huzarski, T., Kurzawski, G., Suchy, J., Masojć, B., Mierzejewski, M., Lener, M., Domagała, W., Chosia, M., Teodorczyk, U., Medrek, K., Debniak, T., Złowocka, E., Gronwald, J., Byrski, T., Grabowska, E., Nej, K., Szymańska, A., Szymańska, J., Matyjasik, J., Cybulski, C., Jakubowska, A., Górski, B., & Narod, S. A. (2005). The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs. Hereditary cancer in clinical practice, 3(2), 59-63. https://doi.org/10.1186/1897-4287-3-2-59
Lubiński, Jan, et al. "The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs." Hereditary cancer in clinical practice vol. 3,2 (2005): 59-63. doi: https://doi.org/10.1186/1897-4287-3-2-59
Lubiński J, Huzarski T, Kurzawski G, Suchy J, Masojć B, Mierzejewski M, Lener M, Domagała W, Chosia M, Teodorczyk U, Medrek K, Debniak T, Złowocka E, Gronwald J, Byrski T, Grabowska E, Nej K, Szymańska A, Szymańska J, Matyjasik J, Cybulski C, Jakubowska A, Górski B, Narod SA. The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs. Hered Cancer Clin Pract. 2005 Mar 15;3(2):59-63. doi: 10.1186/1897-4287-3-2-59. PMID: 20223031; PMCID: PMC2837299.
Copy Download .nbib Format: NLM
Share it on

Hered Cancer Clin Pract. 2005 Mar 15;3(2):59-63. doi: 10.1186/1897-4287-3-2-59.

The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs.

Hereditary cancer in clinical practice

Jan Lubiński, Tomasz Huzarski, Grzegorz Kurzawski, Janina Suchy, Bartłomiej Masojć, Marek Mierzejewski, Marcin Lener, Wenancjusz Domagała, Maria Chosia, Urszula Teodorczyk, Krzysztof Medrek, Tadeusz Debniak, Elzbieta Złowocka, Jacek Gronwald, Tomasz Byrski, Ewa Grabowska, Katarzyna Nej, Anna Szymańska, Jolanta Szymańska, Joanna Matyjasik, Cezary Cybulski, Anna Jakubowska, Bohdan Górski, Steven A Narod

Affiliations

  1. Pomeranian Medical University, Szczecin, Poland. [email protected].

PMID: 20223031 PMCID: PMC2837299 DOI: 10.1186/1897-4287-3-2-59

Abstract

The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals with Crohn's disease are at increased risk for cancer at a number of organ sites. We studied the association between the 3020insC allele of the NOD2 gene and cancer among 2604 cancer patients and 1910 controls from Poland. Patients were diagnosed with one of twelve types of cancer in the Szczecin region between 1994 and 2004. Significant associations were found for colon cancer (OR = 1.8; 95% CI 1.2 to 2.6), for lung cancer (OR = 1.7; 95% CI = 1.1 to 2.5) and for ovarian cancer (OR = 1.6; 95% CI 1.1 to 2.3). In addition, a significant association was found for early-onset laryngeal cancer (OR = 2.9; 95% CI 1.4 to 6.2) and for breast cancer in the presence of DCIS (OR = 2.1 95% CI = 1.2 to 3.6). The NOD2 3020insC allele is relatively common (in Poland 7.3% of individuals) and may be responsible for an important fraction of cancer cases. We estimate that the lifetime cancer risk among carriers of this allele is 30% higher than that of individuals with two wild-type alleles.

References

  1. Apoptosis. 2004 Mar;9(2):123-30 - PubMed
  2. J Biol Chem. 2002 Nov 1;277(44):41701-5 - PubMed
  3. Am J Gastroenterol. 1997 Aug;92(8):1368-71 - PubMed
  4. Cancer Res. 2004 Mar 1;64(5):1655-63 - PubMed
  5. Am J Gastroenterol. 1996 Mar;91(3):434-40 - PubMed
  6. Br J Radiol. 1992 Nov;65(779):1040-2 - PubMed
  7. J Biol Chem. 2001 Feb 16;276(7):4812-8 - PubMed
  8. Aliment Pharmacol Ther. 2003 Sep;18 Suppl 2:1-5 - PubMed
  9. Obstet Gynecol. 1995 Nov;86(5):843-7 - PubMed
  10. Nature. 2001 May 31;411(6837):603-6 - PubMed
  11. Am J Hum Genet. 2000 Jun;66(6):1963-8 - PubMed
  12. Gastroenterology. 1994 Dec;107(6):1675-9 - PubMed
  13. Isr Med Assoc J. 2001 May;3(5):379-80 - PubMed
  14. Cancer Res. 2000 Oct 1;60(19):5334-9 - PubMed
  15. Cancer Res. 2004 Oct 15;64(20):7245-7 - PubMed
  16. Int J Cancer. 2005 Apr 10;114(3):433-5 - PubMed
  17. Nat Genet. 2004 May;36(5):471-5 - PubMed
  18. J Clin Pathol. 1997 Apr;50(4):324-7 - PubMed
  19. Gut. 1998 Feb;42(2):175-9 - PubMed
  20. Lancet. 2001 Jun 16;357(9272):1925-8 - PubMed
  21. J Med Genet. 2002 Oct;39(10):E65 - PubMed
  22. Acta Obstet Gynecol Scand. 1988;67(3):237-40 - PubMed
  23. J Gastroenterol. 2002 Jan;37(1):47-9 - PubMed
  24. Cancer. 2001 Feb 15;91(4):854-62 - PubMed
  25. Int J Colorectal Dis. 2003 Mar;18(2):172-3 - PubMed
  26. Am J Respir Med. 2003;2(3):211-9 - PubMed
  27. Cancer Res. 2004 Mar 1;64(5):1604-6 - PubMed
  28. Digestion. 1990;47(1):1-7 - PubMed

Publication Types