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Lee JS, Ahn JH, Kim DH, et al. Antipsychotic effects of quetiapine in naturalistic long term follow up study. Psychiatry Investig. 2010;7(2):128-34doi: 10.4306/pi.2010.7.2.128.
Lee, J. S., Ahn, J. H., Kim, D. H., Kim, J. J., Kim, T. Y., Yoo, S. Y., Lee, D. G., Lee, S. H., Lim, S. W., Lim, W. J., Jung, I. K., Jung, H. K., Cho, D. H., Cho, I. H., & Kim, C. Y. (2010). Antipsychotic effects of quetiapine in naturalistic long term follow up study. Psychiatry investigation, 7(2), 128-34. https://doi.org/10.4306/pi.2010.7.2.128
Lee, Jung-Sun, et al. "Antipsychotic effects of quetiapine in naturalistic long term follow up study." Psychiatry investigation vol. 7,2 (2010): 128-34. doi: https://doi.org/10.4306/pi.2010.7.2.128
Lee JS, Ahn JH, Kim DH, Kim JJ, Kim TY, Yoo SY, Lee DG, Lee SH, Lim SW, Lim WJ, Jung IK, Jung HK, Cho DH, Cho IH, Kim CY. Antipsychotic effects of quetiapine in naturalistic long term follow up study. Psychiatry Investig. 2010 Jun;7(2):128-34. doi: 10.4306/pi.2010.7.2.128. Epub 2010 May 04. PMID: 20577622; PMCID: PMC2890867.
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Psychiatry Investig. 2010 Jun;7(2):128-34. doi: 10.4306/pi.2010.7.2.128. Epub 2010 May 04.

Antipsychotic effects of quetiapine in naturalistic long term follow up study.

Psychiatry investigation

Jung-Sun Lee, Joon Ho Ahn, Do-Hoon Kim, Jong-Jin Kim, Tae-Young Kim, So-Young Yoo, Dong-Geun Lee, Sang-Hyuk Lee, Se-Won Lim, Weon-Jeong Lim, Il-Kyung Jung, Hae-Kyung Jung, Dong-Hwan Cho, In-Hee Cho, Chang-Yoon Kim

Affiliations

  1. Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

PMID: 20577622 PMCID: PMC2890867 DOI: 10.4306/pi.2010.7.2.128

Abstract

OBJECTIVE: This study aimed to examine the effectiveness of quetiapine and the effects of dosage relates to its effectiveness on schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people.

METHODS: This study was a 24-week, open-label, non-comparative, naturalistic study of quetiapine in patients diagnosed with schizophrenia and schizoaffective disorder according to DSM-IV. We stratified the patients into mild [(clinical global impression severity (CGI-S) <4 at baseline)] and severe groups (CGI-S >/=4 at baseline). We investigated the response rate, defined as clinical global impression improvement (CGI-I)

RESULTS: During the 24 weeks, 151 (18.4%) of the participants dropped out of the study. There was a significant decrease in the mean CGI-S score, from 4.5+/-1.1 at baseline to 2.8+/-1.1 at 24 weeks. The response rate of severe group was 54.5% (estimated by LOCF) and 73.3% (K-M estimated) at 24 weeks. All patients who completed the study had taken a mean quetiapine dosage of 507.9+/-245.9 mg daily. The decrease of CGI-S score in high-dose group (the maximum dose was 750 mg/d or above) was statistically significant than that in recommended-dose group (the maximum dose was less than 750 mg/d).

CONCLUSION: This study demonstrated the long-term effectiveness of quetiapine in the treatment of schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people. This study suggests that higher than recommended quetiapine dosages could be more effective in some patients.

Keywords: High-dose; Naturalistic study; Quetiapine; Schizophrenia

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