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Choi KW, Lee KY, Lee YK, et al. CD4-/CD56+/CD123+ Hematodermic Neoplasm Showing Early Liver Metastasis. Ann Dermatol. 2010;22(2):186-90doi: 10.5021/ad.2010.22.2.186.
Choi, K. W., Lee, K. Y., Lee, Y. K., Ku, B. S., Kim, H. S., Kim, Y. H., & Kim, K. H. (2010). CD4-/CD56+/CD123+ Hematodermic Neoplasm Showing Early Liver Metastasis. Annals of dermatology, 22(2), 186-90. https://doi.org/10.5021/ad.2010.22.2.186
Choi, Kyu-Won, et al. "CD4-/CD56+/CD123+ Hematodermic Neoplasm Showing Early Liver Metastasis." Annals of dermatology vol. 22,2 (2010): 186-90. doi: https://doi.org/10.5021/ad.2010.22.2.186
Choi KW, Lee KY, Lee YK, Ku BS, Kim HS, Kim YH, Kim KH. CD4-/CD56+/CD123+ Hematodermic Neoplasm Showing Early Liver Metastasis. Ann Dermatol. 2010 May;22(2):186-90. doi: 10.5021/ad.2010.22.2.186. Epub 2010 May 18. PMID: 20548910; PMCID: PMC2883422.
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Ann Dermatol. 2010 May;22(2):186-90. doi: 10.5021/ad.2010.22.2.186. Epub 2010 May 18.

CD4-/CD56+/CD123+ Hematodermic Neoplasm Showing Early Liver Metastasis.

Annals of dermatology

Kyu-Won Choi, Ki-Yeol Lee, Yeong-Kyu Lee, Bon-Seok Ku, Hong-Seok Kim, Young-Hun Kim, Ki-Ho Kim

Affiliations

  1. Department of Dermatology, College of Medicine, Dong-A University, Busan, Korea.

PMID: 20548910 PMCID: PMC2883422 DOI: 10.5021/ad.2010.22.2.186

Abstract

Hematodermic neoplasm (HN) is a clinically aggressive neoplasm with a high incidence of cutaneous involvement and a risk of leukemic dissemination. In the recent WHO-EORTC classification, the term blastic natural killer cell lymphoma has been replaced with CD4+/CD56+ HN because of its derivation from a plasmacytoid dendritic cell precursor. Cases of HN that completely lack CD4 or CD56 expression, therefore represents a diagnostic problem. A 68-year-old Korean male was diagnosed with CD4-/CD56+ HN and treated with hyper-CVAD (cyclophosphamide, vincristine, doxorubicin, dexamethasone) at initial treatment, and then switched to high dose methotrexate/cytarabine. His disease relapsed and resulted in death from bone and brain disease 6 months after complete clinical remission, despite diagnostic workups, including a radioisotope liver scan and ultrasound-guided fine needle aspiration biopsy. Further cytogenetic studies such as comparative genomic hybridization could elucidate the genetic mechanisms in the development and progression of lymphomas. We report an unusual case of 'CD4-/CD56+/CD123+ HN' showing early liver metastasis.

Keywords: CD4-/CD56+/CD123+ hematodermic neoplasm; Early liver metastasis

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