Display options
Cite
Rabilloud T, Hochstrasser D, Simpson RJ. Is a gene-centric human proteome project the best way for proteomics to serve biology?. Proteomics. 2010;10(17):3067-72doi: 10.1002/pmic.201000220.
Rabilloud, T., Hochstrasser, D., & Simpson, R. J. (2010). Is a gene-centric human proteome project the best way for proteomics to serve biology?. Proteomics, 10(17), 3067-72. https://doi.org/10.1002/pmic.201000220
Rabilloud, Thierry, et al. "Is a gene-centric human proteome project the best way for proteomics to serve biology?." Proteomics vol. 10,17 (2010): 3067-72. doi: https://doi.org/10.1002/pmic.201000220
Rabilloud T, Hochstrasser D, Simpson RJ. Is a gene-centric human proteome project the best way for proteomics to serve biology?. Proteomics. 2010 Sep;10(17):3067-72. doi: 10.1002/pmic.201000220. PMID: 20648483.
Copy Download .nbib Format: NLM
Share it on

Proteomics. 2010 Sep;10(17):3067-72. doi: 10.1002/pmic.201000220.

Is a gene-centric human proteome project the best way for proteomics to serve biology?.

Proteomics

Thierry Rabilloud, Denis Hochstrasser, Richard J Simpson

Affiliations

  1. Biochemistry and Biophysics of Integrated Systems, UMR CNRS-CEA-UJF 5092, CEA Grenoble, iRTSV/BSBBSI, Grenoble, France. [email protected]

PMID: 20648483 DOI: 10.1002/pmic.201000220

Abstract

With the recent developments in proteomic technologies, a complete human proteome project (HPP) appears feasible for the first time. However, there is still debate as to how it should be designed and what it should encompass. In "proteomics speak", the debate revolves around the central question as to whether a gene-centric or a protein-centric proteomics approach is the most appropriate way forward. In this paper, we try to shed light on what these definitions mean, how large-scale proteomics such as a HPP can insert into the larger omics chorus, and what we can reasonably expect from a HPP in the way it has been proposed so far.

Substances

MeSH terms

Publication Types