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Darnell RB. RNA regulation in neurologic disease and cancer. Cancer Res Treat. 2010;42(3):125-9doi: 10.4143/crt.2010.42.3.125.
Darnell, R. B. (2010). RNA regulation in neurologic disease and cancer. Cancer research and treatment, 42(3), 125-9. https://doi.org/10.4143/crt.2010.42.3.125
Darnell, Robert B. "RNA regulation in neurologic disease and cancer." Cancer research and treatment vol. 42,3 (2010): 125-9. doi: https://doi.org/10.4143/crt.2010.42.3.125
Darnell RB. RNA regulation in neurologic disease and cancer. Cancer Res Treat. 2010 Sep;42(3):125-9. doi: 10.4143/crt.2010.42.3.125. Epub 2010 Sep 30. PMID: 20948916; PMCID: PMC2953774.
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Cancer Res Treat. 2010 Sep;42(3):125-9. doi: 10.4143/crt.2010.42.3.125. Epub 2010 Sep 30.

RNA regulation in neurologic disease and cancer.

Cancer research and treatment

Robert B Darnell

Affiliations

  1. Howard Hughes Medical Institute, Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, NY, USA. [email protected]

PMID: 20948916 PMCID: PMC2953774 DOI: 10.4143/crt.2010.42.3.125

Abstract

The paraneoplastic neurologic diseases (PNDs) are brain degenerations that develop in the setting of clinically inapparent cancers. PNDs arise when common cancers express brain proteins, triggering an anti-tumor immune response and tumor immunity. Research on these brain-cancer proteins has revealed a new world of neuron-specific RNA binding proteins whose functions may be aberrantly used by tumor cells. Efforts to gain insight into their function has led to the development of new methods and strategies to understand RNA protein regulation in living tissues.

Keywords: CLIP; Nova; Paraneoplastic neurologic degeneration; RNA binding protein; Tumor immunity

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