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Platelets. 1991;2(2):59-67. doi: 10.3109/09537109109113690.

The Molecular Genetics of Platelet Membrane Proteins and their Inherited Disorders.

Platelets

D N Cooper

Affiliations

  1. Molecular Genetics Section, Thrombosis Research Institute, Manresa Road, Chelsea, London SW3 6LR, UK.

PMID: 21047281 DOI: 10.3109/09537109109113690

Abstract

The platelet membrane glycoproteins fulfil a vital function in platelet adhesion and aggrkgation. The advent of recombinant DNA technology has provided a wealth of new information on the sequence, structure, expression and chromosomal location of the genes encoding these proteins and Is now permitting the detailed molecular genetic analysis of both Bernard Soulier syndrome and Glanzmann's thrombasthenia.

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