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Immunogenetics. 1978 Dec;7(1):57-61. doi: 10.1007/BF01843988.

Split of HLA-DRw2 into subtypic specificities closely correlated to two HLA-D products.

Immunogenetics

P Richiardi, M Belvedere, I Borelli, M De Marchi, E S Curtoni

Affiliations

  1. Centro CNR Immunogenetica ed Istocompatibilità, Institute of Medical Genetics, University of Turin, Via Santena 19, 10126, Turin, Italy.

PMID: 21302057 DOI: 10.1007/BF01843988

Abstract

Two B-lymphocyte-specific human alloantisera were studied, PA59 and 51.23. They identify two new HLA-DR alleles, which are both subtypic to HLA-DRw2. Moreover, they are closely correlated with two HLA-D products, Dw2 and tb24 (tb24 is a new specificity described by our group). Thus, DRw2 can be "split" into two subtypic specificities that have been named TO60 and TO61, which appear more strongly correlated with HLA-D antigens. Absorption studies demonstrated cytotoxicity-negative, absorption-positive (CYNAP) reactions, and cross-reactive groups of antibodies.

References

  1. Clin Immunol Immunopathol. 1975 Jan;3(3):324-33 - PubMed
  2. Riv Emoter Immunoematol. 1978;25(1-2):18-36 - PubMed

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