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Lechin F, van der Dijs B, Pardey-Maldonado B, et al. Anorexia nervosa depends on adrenal sympathetic hyperactivity: opposite neuroautonomic profile of hyperinsulinism syndrome. Diabetes Metab Syndr Obes. 2010;3:311-7doi: 10.2147/DMSOTT.S10744.
Lechin, F., van der Dijs, B., Pardey-Maldonado, B., Rivera, J. E., Baez, S., & Lechin, M. E. (2010). Anorexia nervosa depends on adrenal sympathetic hyperactivity: opposite neuroautonomic profile of hyperinsulinism syndrome. Diabetes, metabolic syndrome and obesity : targets and therapy, 3311-7. https://doi.org/10.2147/DMSOTT.S10744
Lechin, Fuad, et al. "Anorexia nervosa depends on adrenal sympathetic hyperactivity: opposite neuroautonomic profile of hyperinsulinism syndrome." Diabetes, metabolic syndrome and obesity : targets and therapy vol. 3 (2010): 311-7. doi: https://doi.org/10.2147/DMSOTT.S10744
Lechin F, van der Dijs B, Pardey-Maldonado B, Rivera JE, Baez S, Lechin ME. Anorexia nervosa depends on adrenal sympathetic hyperactivity: opposite neuroautonomic profile of hyperinsulinism syndrome. Diabetes Metab Syndr Obes. 2010 Sep 09;3:311-7. doi: 10.2147/DMSOTT.S10744. PMID: 21437100; PMCID: PMC3047992.
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Diabetes Metab Syndr Obes. 2010 Sep 09;3:311-7. doi: 10.2147/DMSOTT.S10744.

Anorexia nervosa depends on adrenal sympathetic hyperactivity: opposite neuroautonomic profile of hyperinsulinism syndrome.

Diabetes, metabolic syndrome and obesity : targets and therapy

Fuad Lechin, Bertha van der Dijs, Betty Pardey-Maldonado, Jairo E Rivera, Scarlet Baez, Marcel E Lechin

Affiliations

  1. Department of Pathophysiology, Sections of Neuroendocrinology, Neuropharmacology, and Neurochemistry, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Caracas.

PMID: 21437100 PMCID: PMC3047992 DOI: 10.2147/DMSOTT.S10744

Abstract

OBJECTIVE: The aim of our study was to determine the central and peripheral autonomic nervous system profiles underlying anorexia nervosa (AN) syndrome, given that affected patients present with the opposite clinical profile to that seen in the hyperinsulinism syndrome.

DESIGN: We measured blood pressure and heart rate, as well as circulating neurotransmitters (noradrenaline, adrenaline, dopamine, plasma serotonin, and platelet serotonin), using high-performance liquid chromatography with electrochemical detection, during supine resting, one minute of orthostasis, and after five minutes of exercise. In total, 22 AN patients (12 binge-eating/purging type and 10 restricting type) and age-, gender-, and race-matched controls (70 ± 10.1% versus 98 ± 3.0% of ideal body weight) were recruited.

RESULTS: We found that patients with AN had adrenal sympathetic overactivity and neural sympathetic underactivity, demonstrated by a predominance of circulating adrenaline over noradrenaline levels, not only during the supine resting state (52 ± 2 versus 29 ± 1 pg/mL) but also during orthostasis (67 ± 3 versus 32 ± 2 pg/mL, P < 0.05) and after exercise challenge (84 ± 4 versus 30 ± 3 pg/mL, P < 0.01).

CONCLUSION: Considering that this peripheral autonomic nervous system disorder depends on the absolute predominance of adrenomedullary C1 adrenergic nuclei over A5 noradrenergic pontine nucleus, let us ratify the abovementioned findings. The AN syndrome depends on the predominance of overwhelming adrenal sympathetic activity over neural sympathetic activity. This combined central and autonomic nervous system profile contrasts with that registered in patients affected by hyperinsulinism, hypoglycemia, and bulimia syndrome which depends on the absolute predominance of neural sympathetic activity.

Keywords: adrenal sympathetic activity; adrenaline; anorexia nervosa; eating disorders; noradrenaline

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