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Kim DH, Phillips ME, Chang AY, et al. Lateral Connectivity in the Olfactory Bulb is Sparse and Segregated. Front Neural Circuits. 2011;5:5doi: 10.3389/fncir.2011.00005.
Kim, D. H., Phillips, M. E., Chang, A. Y., Patel, H. K., Nguyen, K. T., & Willhite, D. C. (2011). Lateral Connectivity in the Olfactory Bulb is Sparse and Segregated. Frontiers in neural circuits, 55. https://doi.org/10.3389/fncir.2011.00005
Kim, David H, et al. "Lateral Connectivity in the Olfactory Bulb is Sparse and Segregated." Frontiers in neural circuits vol. 5 (2011): 5. doi: https://doi.org/10.3389/fncir.2011.00005
Kim DH, Phillips ME, Chang AY, Patel HK, Nguyen KT, Willhite DC. Lateral Connectivity in the Olfactory Bulb is Sparse and Segregated. Front Neural Circuits. 2011 Apr 25;5:5. doi: 10.3389/fncir.2011.00005. eCollection 2011. PMID: 21559072; PMCID: PMC3084525.
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Front Neural Circuits. 2011 Apr 25;5:5. doi: 10.3389/fncir.2011.00005. eCollection 2011.

Lateral Connectivity in the Olfactory Bulb is Sparse and Segregated.

Frontiers in neural circuits

David H Kim, Matthew E Phillips, Andrew Y Chang, Hetal K Patel, Katherine T Nguyen, David C Willhite

Affiliations

  1. Department of Neurobiology, Yale University School of Medicine New Haven, CT, USA.

PMID: 21559072 PMCID: PMC3084525 DOI: 10.3389/fncir.2011.00005

Abstract

Lateral connections in the olfactory bulb were previously thought to be organized for center-surround inhibition. However, recent anatomical and physiological studies showed sparse and distributed interactions of inhibitory granule cells (GCs) which tended to be organized in columnar clusters. Little is known about how these distributed clusters are interconnected. In this study, we use transsynaptic tracing viruses bearing green or red fluorescent proteins to further elucidate mitral- and tufted-to-GC connectivity. Separate sites in the glomerular layer were injected with each virus. Columns with labeling from both viruses after transsynaptic spread show sparse red or green GCs which tended to be segregated. However, there was a higher incidence of co-labeled cells than chance would predict. Similar segregation of labeling is observed from dual injections into olfactory cortex. Collectively, these results suggest that neighboring mitral and tufted cells receive inhibitory inputs from segregated subsets of GCs, enabling inhibition of a center by specific and discontinuous lateral elements.

Keywords: circuits; connectivity; lateral inhibition; olfaction; olfactory bulb

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