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Wan M, Zweizig S, Dablaing G, et al. 3 distinct regions of chromosome-6 are targets of loss of heterozygosity in human ovarian carcinomas. Int J Oncol. 1994;5(5):1043-8doi: 10.3892/ijo.5.5.1043.
Wan, M., Zweizig, S., Dablaing, G., Zheng, J., Velicescu, M., & Dubeau, L. (1994). 3 distinct regions of chromosome-6 are targets of loss of heterozygosity in human ovarian carcinomas. International journal of oncology, 5(5), 1043-8. https://doi.org/10.3892/ijo.5.5.1043
Wan, M, et al. "3 distinct regions of chromosome-6 are targets of loss of heterozygosity in human ovarian carcinomas." International journal of oncology vol. 5,5 (1994): 1043-8. doi: https://doi.org/10.3892/ijo.5.5.1043
Wan M, Zweizig S, Dablaing G, Zheng J, Velicescu M, Dubeau L. 3 distinct regions of chromosome-6 are targets of loss of heterozygosity in human ovarian carcinomas. Int J Oncol. 1994 Nov;5(5):1043-8. doi: 10.3892/ijo.5.5.1043. PMID: 21559678.
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Int J Oncol. 1994 Nov;5(5):1043-8. doi: 10.3892/ijo.5.5.1043.

3 distinct regions of chromosome-6 are targets of loss of heterozygosity in human ovarian carcinomas.

International journal of oncology

M Wan, S Zweizig, G Dablaing, J Zheng, M Velicescu, L Dubeau

Affiliations

  1. KENNETH NORRIS JR COMPREHENS CANC CTR,DEPT PATHOL,LOS ANGELES,CA 90033. KENNETH NORRIS JR COMPREHENS CANC CTR,DEPT GYNECOL ONCOL,LOS ANGELES,CA 90033.

PMID: 21559678 DOI: 10.3892/ijo.5.5.1043

Abstract

We performed mapping studies of allelic deletions on chromosome 6 in 52 ovarian carcinomas using 20 polymorphic markers assigned to various regions of both chromosomal arms. Loss of heterozygosity was seen in 28 (55%) tumors. The allelic losses, however, did not involve the whole chromosome in 18 of those tumors, allowing further localization of the targeted chromosomal region(s). Three different chromosomal regions appeared involved based on the distribution of partial deletions, 2 on the long arm and one on the short arm. One of the 2 regions on the long arm was confined to band 6q27 whereas the other was between the Arg1 and estrogen receptor loci. The targeted region on the short arm was bounded by the D6S89 and D6S248 loci. These results suggest the presence of at least 3 different tumor suppressor genes important for the control of ovarian tumorigenesis on chromosome 6.

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