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Borlongan CV, Bjugstad KB, Stahl CE, et al. Age-dependent neurobehavioral responses by young and mature adult rats to systemic kainic acid. Restor Neurol Neurosci. 1996;10(2):103-8doi: 10.3233/RNN-1996-10206.
Borlongan, C. V., Bjugstad, K. B., Stahl, C. E., Ross, S. D., Arendash, G. W., Cahill, D. W., & Sanberg, P. R. (1996). Age-dependent neurobehavioral responses by young and mature adult rats to systemic kainic acid. Restorative neurology and neuroscience, 10(2), 103-8. https://doi.org/10.3233/RNN-1996-10206
Borlongan, C V, et al. "Age-dependent neurobehavioral responses by young and mature adult rats to systemic kainic acid." Restorative neurology and neuroscience vol. 10,2 (1996): 103-8. doi: https://doi.org/10.3233/RNN-1996-10206
Borlongan CV, Bjugstad KB, Stahl CE, Ross SD, Arendash GW, Cahill DW, Sanberg PR. Age-dependent neurobehavioral responses by young and mature adult rats to systemic kainic acid. Restor Neurol Neurosci. 1996 Jan 01;10(2):103-8. doi: 10.3233/RNN-1996-10206. PMID: 21551859.
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Restor Neurol Neurosci. 1996 Jan 01;10(2):103-8. doi: 10.3233/RNN-1996-10206.

Age-dependent neurobehavioral responses by young and mature adult rats to systemic kainic acid.

Restorative neurology and neuroscience

C V Borlongan, K B Bjugstad, C E Stahl, S D Ross, G W Arendash, D W Cahill, P R Sanberg

Affiliations

  1. Division of Neurological Surgery, Departments of Surgery, Neurology, Psychiatry and Pharmacology, University of South Florida College of Medicine, MDC Box 16, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.

PMID: 21551859 DOI: 10.3233/RNN-1996-10206

Abstract

Neurobehavioral effects caused by the excitotoxin kainic acid (KA) have been characterized by convulsions including 'wet dog shakes' (WDS) with accompanying hippocampal degeneration in experimental animals. Accordingly, this model has been proposed for putative excitotoxin-mediated disorders, such as the temporal lobe epilepsy. There have been reports on age-dependent neurobehavioral effects of KA; however, little is known about possible correlations between neuropathology and behavioral responses to KA. The present study demonstrates that mature adult rats (12 months old) injected subcutaneously (s.c.) with KA (12 mg/kg) had severer damage to the hippocampal formation, i.e. CA3 region, compared with KA-treated young adult rats (2 months old). The mature adult animals also exhibited an earlier onset of WDS, a significantly higher number of WDS (P > 0.01), and severer convulsions compared with young adult rats. These findings indicate a positive correlation between KA-induced hippocampal damage and behavioral responses in young and mature adult rats.

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