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Curr Protoc Mouse Biol. 2011;1:105-122. doi: 10.1002/9780470942390.mo100149.

Arterial Pressure Monitoring in Mice.

Current protocols in mouse biology

Xin Zhao, David Ho, Shumin Gao, Chull Hong, Dorothy E Vatner, Stephen F Vatner

Affiliations

  1. Department of Cell Biology & Molecular Medicine and the Cardiovascular Research Institute at the University of Medicine & Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, MSB G609, Newark, NJ 07103, USA.

PMID: 21686061 PMCID: PMC3115725 DOI: 10.1002/9780470942390.mo100149

Abstract

The use of mice for the evaluation and study of cardiovascular pathophysiology is growing rapidly, primarily due to the relative ease for developing genetically engineered mouse models. Arterial pressure monitoring is central to the evaluation of the phenotypic changes associated with cardiovascular pathology and interventions in these transgenic and knockout models. There are four major techniques for measuring arterial pressure in the mouse: tail cuff system, implanted fluid filled catheters, Millar catheters and implanted telemetry systems. Here we provide protocols for their use and discuss the advantages and limitations for each of these techniques .

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