Surg Neurol Int. 2011;2:77. doi: 10.4103/2152-7806.82084. Epub 2011 Jun 15.
Trigeminal ganglion neuron density and regulation of anterior choroid artery vasospasm: In a rabbit model of subarachnoid hemorrhage.
Surgical neurology international
Adem Yilmaz, Cemal Gündoğdu, Mehmet Dumlu Aydin, Murat Musluman, Ayhan Kanat, Yunus Aydin
Affiliations
Affiliations
- Department of Neurosurgery, Sisli Research and Education Hospital, Istanbul, Turkey.
PMID: 21748030
PMCID: PMC3130438 DOI: 10.4103/2152-7806.82084
Abstract
BACKGROUND: Subarachnoid hemorrhage (SAH) is associated with severe vasospasm caused by a variety of neurochemical mechanisms. The anterior choroid arteries (AChAs) are innervated by vasodilated fibers of the trigeminal ganglion (TGG). The goal of this study was to determine whether there is a relationship between the neuron density of the TGG and the severity of AChAs vasospasm with SAH.
METHODS: Thirty-two rabbits were used for the study; eight served as the baseline control group, seven as a SHAM group, with injections of 1 cc of isotonic saline solution, and 17 rabbits were included in the experimental SAH group, with injection of homologous blood into the cisterna magna. After 10 days, the histopathology of the AChAs and TGGs were examined. The AChAs vasospasm index (VSI) of the external/internal diameter and the neuron density of the ophthalmic root of the TGGs were evaluated stereologically. The AChAs VSI was preferred -- a measure of the degree of vasospasm. As the VSI increased, the degree of arterial vasospasm increased. The results were statistically analyzed.
RESULTS: The mean AChAs VSI was significantly higher and the mean neuronal density of the ophthalmic root of the TGG was significantly lower in the group with severe vasospasm associated with SAH compared to the controls, SHAM, and the group with mild vasospasm associated with SAH (P< 0.05). The ophthalmic root of the TGG neuron density in the 7 rabbits that developed severe vasospasm was statistically less than that observed in the 10 rabbits with mild vasospasm. There was a linear relationship between the low neuronal density in the ophthalmic root of the TGG and the severity of the AChA vasospasm.
CONCLUSIONS: The trigeminal ganglion neuron density may be an important factor in the regulation of AChAs diameter and cerebral blood flow. Low neuron density of the ophthalmic root of the TGG may play a role in the pathogenesis of AChAs vasospasm associated with SAH.
Keywords: Anterior choroid artery; neuron density; subarachnoid hemorrhage; trigeminal ganglion; vasospasm; vasospasm index
References
- Surg Neurol. 1979 Aug;12(2):171-87 - PubMed
- Acta Neurochir (Wien). 2010 Dec;152(12):2167-72 - PubMed
- Surg Neurol. 1976 Aug;6(2):83-91 - PubMed
- Acta Neuropathol. 2010 Jan;119(1):75-88 - PubMed
- Stroke. 1985 Jul-Aug;16(4):562-72 - PubMed
- Neurol Med Chir (Tokyo). 1998;38 Suppl:146-51 - PubMed
- J Cereb Blood Flow Metab. 2006 May;26(5):675-83 - PubMed
- Stroke. 2009 Mar;40(3):994-1025 - PubMed
- J Auton Nerv Syst. 1994 Sep;49 Suppl:S167-70 - PubMed
- Brain Res. 1997 Mar 21;751(2):247-52 - PubMed
- J Neurosurg. 1984 Sep;61(3):468-85 - PubMed
- J Microsc. 1984 May;134(Pt 2):127-36 - PubMed
- J Neurosurg. 1977 May;46(5):563-78 - PubMed
- APMIS. 1988 May;96(5):379-94 - PubMed
- Minim Invasive Neurosurg. 2006 Dec;49(6):359-61 - PubMed
- Life Sci. 1993;52(9):825-34 - PubMed
- Acta Neurochir (Wien). 1989;100(1-2):12-24 - PubMed
- Brain Res. 1983 May 23;268(1):162-6 - PubMed
- Lancet. 1979 Oct 27;2(8148):883-5 - PubMed
- Brain Res. 1996 Feb 5;708(1-2):197-200 - PubMed
- Stroke. 1995 Jun;26(6):1086-91; discussion 1091-2 - PubMed
- Neurosurgery. 1993 May;32(5):822-7; discussion 827 - PubMed
- J Auton Nerv Syst. 1998 May 28;70(1-2):15-22 - PubMed
- J Neurosurg. 2002 Nov;97(5):1179-83 - PubMed
- Neuroscience. 1986 Nov;19(3):695-708 - PubMed
- Neurol Res. 1996 Oct;18(5):394-400 - PubMed
- Acta Neurol Scand Suppl. 1992;141:1-33 - PubMed
- Neurosurgery. 1993 Jun;32(6):993-9; discussion 999 - PubMed
- Neurosurgery. 1990 Oct;27(4):574-7 - PubMed
- Am J Physiol. 1990 Apr;258(4 Pt 1):L148-56 - PubMed
Publication Types