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Belof JL, Cioce CR, Xu X, et al. Characterization of Tunable Radical Metal-Carbenes: Key Intermediates in Catalytic Cyclopropanation. Organometallics. 2011;30(10):2739-2746doi: 10.1021/om2001348.
Belof, J. L., Cioce, C. R., Xu, X., Zhang, X. P., Space, B., & Woodcock, H. L. (2011). Characterization of Tunable Radical Metal-Carbenes: Key Intermediates in Catalytic Cyclopropanation. Organometallics, 30(10), 2739-2746. https://doi.org/10.1021/om2001348
Belof, Jonathan L, et al. "Characterization of Tunable Radical Metal-Carbenes: Key Intermediates in Catalytic Cyclopropanation." Organometallics vol. 30,10 (2011): 2739-2746. doi: https://doi.org/10.1021/om2001348
Belof JL, Cioce CR, Xu X, Zhang XP, Space B, Woodcock HL. Characterization of Tunable Radical Metal-Carbenes: Key Intermediates in Catalytic Cyclopropanation. Organometallics. 2011 Apr 29;30(10):2739-2746. doi: 10.1021/om2001348. PMID: 21643517; PMCID: PMC3105361.
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Organometallics. 2011 Apr 29;30(10):2739-2746. doi: 10.1021/om2001348.

Characterization of Tunable Radical Metal-Carbenes: Key Intermediates in Catalytic Cyclopropanation.

Organometallics

Jonathan L Belof, Christian R Cioce, Xue Xu, X Peter Zhang, Brian Space, H Lee Woodcock

Affiliations

  1. Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., CHE205, Tampa, FL 33620-5250.

PMID: 21643517 PMCID: PMC3105361 DOI: 10.1021/om2001348

Abstract

A new class of radical metal-carbene complex has been characterized as having Fischer-like orbital interactions and adjacent π acceptor stabilization. Density Functional Theory (DFT) along with Natural Bond Orbital (NBO) analysis and Charge Decomposition Analysis (CDA) has given insight into the electronics of this catalytic intermediate in an open-shell cobalt-porphyrin, [Co(Por)], system. The complex has a single bond from the metal to the carbene and has radical character with localized spin density on the carbene carbon. In addition, the carbene carbon is found to be nucleophilic and "tunable" through the introduction of different α-carbon substituents. Finally, based on these findings, rational design strategies are proposed which should lead to the enhancement of catalytic activity.

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