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Zheng J, Xiao X, Liu J, et al. Growth-promoting effect of environmental endocrine disruptors on human neuroblastoma SK-N-SH cells. Environ Toxicol Pharmacol. 2007;24(2):189-93doi: 10.1016/j.etap.2007.05.003.
Zheng, J., Xiao, X., Liu, J., Zheng, S., Yin, Q., & Yu, Y. (2007). Growth-promoting effect of environmental endocrine disruptors on human neuroblastoma SK-N-SH cells. Environmental toxicology and pharmacology, 24(2), 189-93. https://doi.org/10.1016/j.etap.2007.05.003
Zheng, Jicui, et al. "Growth-promoting effect of environmental endocrine disruptors on human neuroblastoma SK-N-SH cells." Environmental toxicology and pharmacology vol. 24,2 (2007): 189-93. doi: https://doi.org/10.1016/j.etap.2007.05.003
Zheng J, Xiao X, Liu J, Zheng S, Yin Q, Yu Y. Growth-promoting effect of environmental endocrine disruptors on human neuroblastoma SK-N-SH cells. Environ Toxicol Pharmacol. 2007 Sep;24(2):189-93. doi: 10.1016/j.etap.2007.05.003. Epub 2007 May 16. PMID: 21783809.
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Environ Toxicol Pharmacol. 2007 Sep;24(2):189-93. doi: 10.1016/j.etap.2007.05.003. Epub 2007 May 16.

Growth-promoting effect of environmental endocrine disruptors on human neuroblastoma SK-N-SH cells.

Environmental toxicology and pharmacology

Jicui Zheng, Xianmin Xiao, Jiangbin Liu, Shan Zheng, Qiyou Yin, Yong Yu

Affiliations

  1. Department of Surgery, Children's Hospital, Shanghai Medical College, Fudan University, 183 Feng Lin Road, Shanghai 200032, China.

PMID: 21783809 DOI: 10.1016/j.etap.2007.05.003

Abstract

Bisphenol A (BPA), a monomer component of polycarbonate plastics and epoxy resins, is widely used in many consumer products. Zearalenone (ZEA), a non-steroidal estrogenic mycotoxin, is present in high concentrations in dairy products and cereals. Numerous researches describe a possible correlation between environmental endocrine disruptors and human tumors, but only a few papers concerned solid tumors in childhood. We investigated the effects of BPA and ZEA on the proliferation in the human neuroblastoma SK-N-SH cell line. Cell counting kit-8 and flow cytometric analysis were used to determine whether BPA and ZEA promote cell proliferation. The results indicated that BPA and ZEA-mediated increase in cell proliferation is significant (p<0.05). To explore the possible underlying mechanism, additive effect of the estrogen receptor antagonist ICI182780 or insulin-like growth factor I (IGF-I) was observed. ICI182780 could inhibit these proliferative effects of BPA and ZEA. However, no synergistic or additive growth-promoting effect was noted when IGF-1 was added. These results suggested that BPA and ZEA can promote the proliferation of SK-N-SH cells, and the estrogen receptor pathway may be involved in this effect.

Copyright © 2007 Elsevier B.V. All rights reserved.

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