Display options
Cite
Kasai Y, Cagan R. Drosophila as a tool for personalized medicine: a primer. Per Med. 2010;7(6):621-632doi: 10.2217/pme.10.65.
Kasai, Y., & Cagan, R. (2010). Drosophila as a tool for personalized medicine: a primer. Personalized medicine, 7(6), 621-632. https://doi.org/10.2217/pme.10.65
Kasai, Yumi, and Cagan, Ross. "Drosophila as a tool for personalized medicine: a primer." Personalized medicine vol. 7,6 (2010): 621-632. doi: https://doi.org/10.2217/pme.10.65
Kasai Y, Cagan R. Drosophila as a tool for personalized medicine: a primer. Per Med. 2010 Nov;7(6):621-632. doi: 10.2217/pme.10.65. PMID: 21977050; PMCID: PMC3184507.
Copy Download .nbib Format: NLM
Share it on

Per Med. 2010 Nov;7(6):621-632. doi: 10.2217/pme.10.65.

Drosophila as a tool for personalized medicine: a primer.

Personalized medicine

Yumi Kasai, Ross Cagan

Affiliations

  1. Department of Genetics & Genomic Sciences, Mount Sinai School of Medicine, One Gustave L Levy Place, NY 10029-6574, USA.

PMID: 21977050 PMCID: PMC3184507 DOI: 10.2217/pme.10.65

Abstract

The goal of personalized medicine is to treat each patient with the best drug: optimal therapeutic benefit with minimal side effects. The genomic revolution is rapidly identifying the genetic contribution to the diseased state as well as its contribution to drug efficacy and toxicity. The ability to perform genome-wide studies has led to an overwhelming number of candidate genes and/or their associated variants; however, understanding which are of therapeutic importance is becoming the greatest unmet need in the personalized medicine field. A related issue is the need to improve our methods of identifying and characterizing therapeutic drugs in the context of the complex genomic landscape of the intact body. Drosophila have proven to be a powerful tool for understanding the basic biological mechanisms of human development. This article will review Drosophila as a whole animal tool for gene and drug discovery. We will examine how Drosophila can be used to both sort through the myriad of hits coming from human genome-wide scans and to dramatically improve the early steps in pharmaceutical drug development.

References

  1. Cell. 1991 Aug 9;66(3):451-64 - PubMed
  2. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):82-6 - PubMed
  3. Science. 2004 Apr 2;304(5667):100-4 - PubMed
  4. Clin Lab Med. 2004 Mar;24(1):49-83 - PubMed
  5. Science. 2002 Feb 1;295(5556):865-8 - PubMed
  6. Methods Cell Biol. 1994;44:635-54 - PubMed
  7. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5395-400 - PubMed
  8. Dev Biol. 1985 Feb;107(2):355-63 - PubMed
  9. Trends Cardiovasc Med. 2007 Jul;17(5):177-82 - PubMed
  10. Cold Spring Harb Symp Quant Biol. 2006;71:39-44 - PubMed
  11. Nat Chem Biol. 2008 Apr;4(4):256-63 - PubMed
  12. J Biol Chem. 1999 Mar 19;274(12):8335-43 - PubMed
  13. Mol Cell. 2010 Feb 12;37(3):321-32 - PubMed
  14. Nature. 2001 Oct 18;413(6857):739-43 - PubMed
  15. J Clin Oncol. 2010 Feb 10;28(5):767-72 - PubMed
  16. Clin Transl Oncol. 2009 Jan;11(1):11-9 - PubMed
  17. Cancer Res. 2009 Feb 15;69(4):1383-91 - PubMed
  18. PLoS Genet. 2009 Feb;5(2):e1000374 - PubMed
  19. Cancer Res. 2002 Jun 15;62(12):3402-7 - PubMed
  20. Neuron. 2003 Sep 25;40(1):25-40 - PubMed
  21. Cell. 1998 Jun 12;93(6):939-49 - PubMed
  22. Science. 2000 Mar 10;287(5459):1837-40 - PubMed
  23. Stem Cell Rev. 2007 Jun;3(2):169-75 - PubMed
  24. J Clin Invest. 1991 May;87(5):1691-9 - PubMed
  25. Nature. 1993 Jun 3;363(6428):458-60 - PubMed
  26. Science. 2005 May 6;308(5723):826-33 - PubMed
  27. Nat Neurosci. 2005 May;8(5):657-63 - PubMed
  28. Carcinogenesis. 2007 Feb;28(2):435-45 - PubMed
  29. Cancer Res. 2002 Dec 15;62(24):7284-90 - PubMed
  30. Cell. 2003 May 16;113(4):457-68 - PubMed
  31. Development. 1994 Jun;120(6):1385-98 - PubMed
  32. Development. 2007 Oct;134(20):3571-84 - PubMed
  33. Gene. 2004 Nov 10;342(1):1-11 - PubMed
  34. Annu Rev Biochem. 2010;79:37-64 - PubMed
  35. Genetics. 1999 Feb;151(2):725-37 - PubMed
  36. Dev Genet. 1998;22(3):181-6 - PubMed
  37. Science. 2006 Jul 21;313(5785):324-8 - PubMed
  38. Nature. 2006 Jun 29;441(7097):1162-6 - PubMed
  39. Int J Cancer. 2000 Oct 1;88(1):44-52 - PubMed
  40. Cancer Biol Ther. 2009 Nov;8(21):1986-93 - PubMed
  41. Nat Methods. 2009 Jun;6(6):431-4 - PubMed
  42. Nat Genet. 2005 Dec;37(12):1323-32 - PubMed
  43. Nature. 2006 Jun 29;441(7097):1157-61 - PubMed
  44. Dev Cell. 2005 Nov;9(5):711-20 - PubMed
  45. Oncogene. 2004 Nov 1;23(51):8359-65 - PubMed
  46. Cancer Cell. 2004 Sep;6(3):209-14 - PubMed
  47. J Biol Chem. 1998 Oct 23;273(43):28504-9 - PubMed
  48. EMBO J. 2003 Nov 3;22(21):5769-79 - PubMed
  49. J Biol Chem. 2001 Sep 7;276(36):33711-20 - PubMed
  50. Neuron. 2003 Mar 27;37(6):911-24 - PubMed
  51. Breast Cancer Res Treat. 2006 Jun;97(3):263-74 - PubMed
  52. Front Biosci. 2007 Jan 01;12:39-48 - PubMed
  53. Neuron. 1998 Sep;21(3):633-42 - PubMed
  54. Cancer. 2004 Sep 1;101(5):1018-27 - PubMed
  55. Nat Genet. 2004 Dec;36(12):1275-81 - PubMed
  56. Nat Chem Biol. 2007 Jun;3(6):331-8 - PubMed
  57. FEBS Lett. 2003 May 22;543(1-3):76-80 - PubMed
  58. Trends Genet. 2004 Aug;20(8):384-91 - PubMed
  59. Neuron. 2008 Jan 10;57(1):27-40 - PubMed
  60. Dev Cell. 2005 Nov;9(5):699-710 - PubMed
  61. Oncogene. 1994 Dec;9(12):3601-8 - PubMed
  62. Science. 2003 Mar 28;299(5615):2039-45 - PubMed
  63. JAMA. 2008 Apr 2;299(13):1574-87 - PubMed
  64. Cancer Res. 2007 May 1;67(9):4164-72 - PubMed
  65. Genetics. 2005 Nov;171(3):1057-81 - PubMed
  66. Nature. 2006 Jan 26;439(7075):430-6 - PubMed
  67. Development. 1993 Jun;118(2):401-15 - PubMed
  68. Science. 2002 May 10;296(5570):1118-20 - PubMed
  69. Cancer Res. 2007 Nov 1;67(21):10278-85 - PubMed
  70. Oncogene. 2007 May 24;26(24):3503-10 - PubMed
  71. Nature. 2000 Nov 2;408(6808):101-6 - PubMed
  72. Cancer Res. 2005 Mar 1;65(5):1858-67 - PubMed
  73. Nat Med. 2002 Nov;8(11):1185-6 - PubMed
  74. Nature. 2006 Nov 9;444(7116):230-4 - PubMed
  75. Cancer Res. 2005 May 1;65(9):3538-41 - PubMed
  76. Dev Biol. 1999 Jan 1;205(1):129-44 - PubMed
  77. J Neurosci. 2004 Mar 17;24(11):2648-55 - PubMed
  78. Mech Dev. 2003 Jun;120(6):681-9 - PubMed
  79. Neuron. 2006 Aug 17;51(4):441-54 - PubMed
  80. Mol Cell Biol. 2010 Jan;30(2):481-95 - PubMed
  81. Oncogene. 1997 Dec 18;15(25):3083-90 - PubMed
  82. J Biol Chem. 2007 Apr 6;282(14):10697-706 - PubMed
  83. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3943-8 - PubMed
  84. J Vis Exp. 2009 Oct 13;(32): - PubMed
  85. Nature. 2000 Mar 23;404(6776):394-8 - PubMed

Publication Types

Grant support