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Woo YS, Bahk WM, Jo SH, et al. Effect of initial ziprasidone dose on treatment outcome of korean patients with acute manic or mixed episodes. Psychiatry Investig. 2011;8(3):207-13doi: 10.4306/pi.2011.8.3.207.
Woo, Y. S., Bahk, W. M., Jo, S. H., Yoon, B. H., Lee, J. G., Kim, W., Jeong, J. H., Seo, J. S., Min, K. J., & Jon, D. I. (2011). Effect of initial ziprasidone dose on treatment outcome of korean patients with acute manic or mixed episodes. Psychiatry investigation, 8(3), 207-13. https://doi.org/10.4306/pi.2011.8.3.207
Woo, Young Sup, et al. "Effect of initial ziprasidone dose on treatment outcome of korean patients with acute manic or mixed episodes." Psychiatry investigation vol. 8,3 (2011): 207-13. doi: https://doi.org/10.4306/pi.2011.8.3.207
Woo YS, Bahk WM, Jo SH, Yoon BH, Lee JG, Kim W, Jeong JH, Seo JS, Min KJ, Jon DI. Effect of initial ziprasidone dose on treatment outcome of korean patients with acute manic or mixed episodes. Psychiatry Investig. 2011 Sep;8(3):207-13. doi: 10.4306/pi.2011.8.3.207. Epub 2011 Aug 02. PMID: 21994507; PMCID: PMC3182385.
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Psychiatry Investig. 2011 Sep;8(3):207-13. doi: 10.4306/pi.2011.8.3.207. Epub 2011 Aug 02.

Effect of initial ziprasidone dose on treatment outcome of korean patients with acute manic or mixed episodes.

Psychiatry investigation

Young Sup Woo, Won-Myong Bahk, Soo Hyun Jo, Bo-Hyun Yoon, Jung Goo Lee, Won Kim, Jong-Hyun Jeong, Jeong Seok Seo, Kyung Joon Min, Duk-In Jon

Affiliations

  1. Department of Psychiatry, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

PMID: 21994507 PMCID: PMC3182385 DOI: 10.4306/pi.2011.8.3.207

Abstract

OBJECTIVE: We investigated the efficacy and tolerability of ziprasidone combined with divalproex to determine the relationship between the initial dose of ziprasidone and the treatment effect among Korean patients with acute bipolar manic or mixed disorders.

METHODS: This study was a 6-week, open-label, prospective investigation of Korean patients with an acute manic or mixed episode of bipolar disorder. Sixty-five patients were recruited. The patients were categorized based on the initial dose of ziprasidone as follows: low (20-79 mg/day) and standard (80 mg/day). Ziprasidone was given in combination with divalproex in flexible doses, according to the clinical response and tolerability.

RESULTS: The response and remission rates were significantly higher in the standard-dose group than the low-dose group. The combination of ziprasidone and divalproex was well-tolerated and adverse events were mostly mild with no statistically significant increase in body weight.

CONCLUSION: The results of this study showed that a standard starting dose of ziprasidone in combination with divalproex for bipolar disorder is more effective than a low starting dose.

Keywords: Bipolar disorder; Divalproex; Initial dose; Manic episode; Ziprasidone

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