Display options
Cite
van Uden IW, van Norden AG, de Laat KF, et al. Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study. J Aging Res. 2011;2011:647869doi: 10.4061/2011/647869.
van Uden, I. W., van Norden, A. G., de Laat, K. F., van Oudheusden, L. J., Gons, R. A., Tendolkar, I., Zwiers, M. P., & de Leeuw, F. E. (2011). Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study. Journal of aging research, 2011647869. https://doi.org/10.4061/2011/647869
van Uden, I W M, et al. "Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study." Journal of aging research vol. 2011 (2011): 647869. doi: https://doi.org/10.4061/2011/647869
van Uden IW, van Norden AG, de Laat KF, van Oudheusden LJ, Gons RA, Tendolkar I, Zwiers MP, de Leeuw FE. Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study. J Aging Res. 2011;2011:647869. doi: 10.4061/2011/647869. Epub 2011 Oct 06. PMID: 22007299; PMCID: PMC3189594.
Copy Download .nbib Format: NLM
Share it on

J Aging Res. 2011;2011:647869. doi: 10.4061/2011/647869. Epub 2011 Oct 06.

Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study.

Journal of aging research

I W M van Uden, A G W van Norden, K F de Laat, L J B van Oudheusden, R A R Gons, I Tendolkar, M P Zwiers, F-E de Leeuw

Affiliations

  1. Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Reinier Postlaan 4, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

PMID: 22007299 PMCID: PMC3189594 DOI: 10.4061/2011/647869

Abstract

Introduction. Late onset depressive symptoms (LODSs) frequently occur in elderly with cerebral small vessel disease (SVD). SVD cannot fully explain LODS; a contributing factor could be amygdala volume. We investigated the relation between amygdala volume and LODS, independent of SVD in 503 participants with symptomatic cerebral SVD. Methods. Patients underwent FLAIR and T1 scanning. Depressive symptoms were assessed with structured questionnaires; amygdala and WML were manually segmented. The relation between amygdala volume and LODS/EODS was investigated and adjusted for age, sex, intracranial volume, and SVD. Results. Patients with LODS had a significantly lower left amygdala volume than those without (P = 0.02), independent of SVD. Each decrease of total amygdala volume (by mL) was related to an increased risk of LODS (OR = 1.77; 95% CI 1.02-3.08; P = 0.04). Conclusion. Lower left amygdala volume is associated with LODS, independent of SVD. This may suggest differential mechanisms, in which individuals with a small amygdala might be vulnerable to develop LODS.

References

  1. Biol Psychiatry. 2010 Jul 15;68(2):133-9 - PubMed
  2. Arch Gen Psychiatry. 2000 Nov;57(11):1071-6 - PubMed
  3. Neurology. 1993 Feb;43(2):250-60 - PubMed
  4. J Neurol Neurosurg Psychiatry. 2001 Jan;70(1):9-14 - PubMed
  5. Psychol Med. 1999 May;29(3):629-38 - PubMed
  6. Neurology. 2008 Apr 8;70(15):1258-64 - PubMed
  7. J Neurol Neurosurg Psychiatry. 2008 Jun;79(6):619-24 - PubMed
  8. Am J Geriatr Psychiatry. 2007 Jun;15(6):487-96 - PubMed
  9. Biol Psychiatry. 2003 Feb 15;53(4):338-44 - PubMed
  10. BMC Neurol. 2011 Feb 28;11:29 - PubMed
  11. Arch Neurol. 1999 Jan;56(1):33-9 - PubMed
  12. Brain Res Brain Res Rev. 2002 Jun;39(1):84-105 - PubMed
  13. Arch Gen Psychiatry. 1997 Oct;54(10):915-22 - PubMed
  14. J Neuropsychiatry Clin Neurosci. 1991 Winter;3(1):33-40 - PubMed
  15. Psychol Med. 2004 Aug;34(6):1059-64 - PubMed
  16. J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):439-42 - PubMed
  17. Lancet Neurol. 2002 Nov;1(7):426-36 - PubMed
  18. Biol Psychiatry. 2008 Apr 1;63(7):663-9 - PubMed
  19. Rev Neurol (Paris). 2008 Oct;164(10):837-40 - PubMed
  20. Int J Geriatr Psychiatry. 2009 Aug;24(8):837-46 - PubMed
  21. Br J Psychiatry. 2007 Nov;191:393-401 - PubMed
  22. Biol Psychiatry. 2004 Mar 15;55(6):563-9 - PubMed
  23. Ann Med. 2000 May;32(4):252-6 - PubMed
  24. Am J Psychiatry. 1997 Apr;154(4):497-501 - PubMed
  25. Biol Psychiatry. 2002 Sep 1;52(5):404-12 - PubMed
  26. Mol Psychiatry. 2005 Feb;10(2):147-59 - PubMed
  27. Stroke. 2005 Nov;36(11):2384-8 - PubMed
  28. Psychol Med. 2000 Jan;30(1):117-25 - PubMed
  29. Biol Psychiatry. 2000 Oct 15;48(8):791-800 - PubMed
  30. Eur Arch Psychiatry Clin Neurosci. 1993;243(1):41-6 - PubMed
  31. Neurology. 1984 Jul;34(7):939-44 - PubMed
  32. Neurology. 2005 Jan 25;64(2):263-7 - PubMed
  33. Cerebrovasc Dis. 2002;13 Suppl 2:58-60 - PubMed
  34. Ann N Y Acad Sci. 2003 Apr;985:481-4 - PubMed
  35. Biol Psychiatry. 1999 May 1;45(9):1085-98 - PubMed
  36. Neuroimage. 2003 Jul;19(3):513-31 - PubMed
  37. Curr Opin Psychiatry. 2006 Jan;19(1):25-33 - PubMed
  38. Arch Gen Psychiatry. 1993 Jan;50(1):7-16 - PubMed
  39. Nat Neurosci. 2001 Apr;4(4):437-41 - PubMed
  40. Neuroimage. 2006 Jul 1;31(3):1116-28 - PubMed
  41. Brain. 1995 Feb;118 ( Pt 1):15-24 - PubMed
  42. Lancet. 2006 Jan 14;367(9505):153-67 - PubMed
  43. Nature. 1997 Jan 16;385(6613):254-7 - PubMed
  44. J Psychiatr Res. 2007 Apr-Jun;41(3-4):247-54 - PubMed
  45. Am J Psychiatry. 1992 May;149(5):620-5 - PubMed
  46. Am J Geriatr Psychiatry. 2012 Jun;20(6):524-32 - PubMed
  47. Neuroreport. 1998 Jun 22;9(9):2023-8 - PubMed
  48. Neuropsychopharmacology. 2004 May;29(5):952-9 - PubMed
  49. Br J Psychiatry. 1981 Nov;139:463-6 - PubMed

Publication Types