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Functional diffusion tensor imaging at 3 Tesla.

Frontiers in human neuroscience

Mandl RC, Schnack HG, Zwiers MP, Kahn RS, Hulshoff Pol HE.
PMID: 24409133
Front Hum Neurosci. 2013 Dec 03;7:817. doi: 10.3389/fnhum.2013.00817. eCollection 2013.

In a previous study we reported on a non-invasive functional diffusion tensor imaging (fDTI) method to measure neuronal signals directly from subtle changes in fractional anisotropy along white matter tracts. We hypothesized that these fractional anisotropy changes relate to...

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Mandl RC, Schnack HG, Zwiers MP, et al. Functional diffusion tensor imaging at 3 Tesla. Front Hum Neurosci. 2013;7:817doi: 10.3389/fnhum.2013.00817.
Mandl, R. C., Schnack, H. G., Zwiers, M. P., Kahn, R. S., & Hulshoff Pol, H. E. (2013). Functional diffusion tensor imaging at 3 Tesla. Frontiers in human neuroscience, 7817. https://doi.org/10.3389/fnhum.2013.00817
Mandl, René C W, et al. "Functional diffusion tensor imaging at 3 Tesla." Frontiers in human neuroscience vol. 7 (2013): 817. doi: https://doi.org/10.3389/fnhum.2013.00817
Mandl RC, Schnack HG, Zwiers MP, Kahn RS, Hulshoff Pol HE. Functional diffusion tensor imaging at 3 Tesla. Front Hum Neurosci. 2013 Dec 03;7:817. doi: 10.3389/fnhum.2013.00817. eCollection 2013. PMID: 24409133; PMCID: PMC3847896.
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Recent advances in the etiology and treatment of inflammatory bowel disease.

Expert review of clinical immunology

Zwiers A, Bouma G.
PMID: 20477075
Expert Rev Clin Immunol. 2006 Mar;2(2):245-56. doi: 10.1586/1744666X.2.2.245.

Crohn's disease and ulcerative colitis, together comprising the inflammatory bowel diseases, currently affect up to 2 million people in the western developed countries. The pathogenesis of the disease is a complex one in which genetic, immunogenic, microbial and environmental...

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Zwiers A, Bouma G. Recent advances in the etiology and treatment of inflammatory bowel disease. Expert Rev Clin Immunol. 2006;2(2):245-56doi: 10.1586/1744666X.2.2.245.
Zwiers, A., & Bouma, G. (2006). Recent advances in the etiology and treatment of inflammatory bowel disease. Expert review of clinical immunology, 2(2), 245-56. https://doi.org/10.1586/1744666X.2.2.245
Zwiers, A, and Bouma, G. "Recent advances in the etiology and treatment of inflammatory bowel disease." Expert review of clinical immunology vol. 2,2 (2006): 245-56. doi: https://doi.org/10.1586/1744666X.2.2.245
Zwiers A, Bouma G. Recent advances in the etiology and treatment of inflammatory bowel disease. Expert Rev Clin Immunol. 2006 Mar;2(2):245-56. doi: 10.1586/1744666X.2.2.245. PMID: 20477075.
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Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study.

Journal of aging research

van Uden IW, van Norden AG, de Laat KF, van Oudheusden LJ, Gons RA, Tendolkar I, Zwiers MP, de Leeuw FE.
PMID: 22007299
J Aging Res. 2011;2011:647869. doi: 10.4061/2011/647869. Epub 2011 Oct 06.

Introduction. Late onset depressive symptoms (LODSs) frequently occur in elderly with cerebral small vessel disease (SVD). SVD cannot fully explain LODS; a contributing factor could be amygdala volume. We investigated the relation between amygdala volume and LODS, independent of...

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van Uden IW, van Norden AG, de Laat KF, et al. Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study. J Aging Res. 2011;2011:647869doi: 10.4061/2011/647869.
van Uden, I. W., van Norden, A. G., de Laat, K. F., van Oudheusden, L. J., Gons, R. A., Tendolkar, I., Zwiers, M. P., & de Leeuw, F. E. (2011). Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study. Journal of aging research, 2011647869. https://doi.org/10.4061/2011/647869
van Uden, I W M, et al. "Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study." Journal of aging research vol. 2011 (2011): 647869. doi: https://doi.org/10.4061/2011/647869
van Uden IW, van Norden AG, de Laat KF, van Oudheusden LJ, Gons RA, Tendolkar I, Zwiers MP, de Leeuw FE. Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study. J Aging Res. 2011;2011:647869. doi: 10.4061/2011/647869. Epub 2011 Oct 06. PMID: 22007299; PMCID: PMC3189594.
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No Association between Cortical Gyrification or Intrinsic Curvature and Attention-deficit/Hyperactivity Disorder in Adolescents and Young Adults.

Frontiers in neuroscience

Forde NJ, Ronan L, Zwiers MP, Alexander-Bloch AF, Faraone SV, Oosterlaan J, Heslenfeld DJ, Hartman CA, Buitelaar JK, Hoekstra PJ.
PMID: 28473750
Front Neurosci. 2017 Apr 20;11:218. doi: 10.3389/fnins.2017.00218. eCollection 2017.

Magnetic resonance imaging (MRI) studies have highlighted subcortical, cortical, and structural connectivity abnormalities associated with attention-deficit/hyperactivity disorder (ADHD). Gyrification investigations of the cortex have been inconsistent and largely negative, potentially due to a lack of sensitivity of the previously...

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Forde NJ, Ronan L, Zwiers MP, et al. No Association between Cortical Gyrification or Intrinsic Curvature and Attention-deficit/Hyperactivity Disorder in Adolescents and Young Adults. Front Neurosci. 2017;11:218doi: 10.3389/fnins.2017.00218.
Forde, N. J., Ronan, L., Zwiers, M. P., Alexander-Bloch, A. F., Faraone, S. V., Oosterlaan, J., Heslenfeld, D. J., Hartman, C. A., Buitelaar, J. K., & Hoekstra, P. J. (2017). No Association between Cortical Gyrification or Intrinsic Curvature and Attention-deficit/Hyperactivity Disorder in Adolescents and Young Adults. Frontiers in neuroscience, 11218. https://doi.org/10.3389/fnins.2017.00218
Forde, Natalie J, et al. "No Association between Cortical Gyrification or Intrinsic Curvature and Attention-deficit/Hyperactivity Disorder in Adolescents and Young Adults." Frontiers in neuroscience vol. 11 (2017): 218. doi: https://doi.org/10.3389/fnins.2017.00218
Forde NJ, Ronan L, Zwiers MP, Alexander-Bloch AF, Faraone SV, Oosterlaan J, Heslenfeld DJ, Hartman CA, Buitelaar JK, Hoekstra PJ. No Association between Cortical Gyrification or Intrinsic Curvature and Attention-deficit/Hyperactivity Disorder in Adolescents and Young Adults. Front Neurosci. 2017 Apr 20;11:218. doi: 10.3389/fnins.2017.00218. eCollection 2017. PMID: 28473750; PMCID: PMC5397412.
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Attributing extreme fire risk in Western Canada to human emissions.

Climatic change

Kirchmeier-Young MC, Zwiers FW, Gillett NP, Cannon AJ.
PMID: 32009687
Clim Change. 2017;144(2):365-379. doi: 10.1007/s10584-017-2030-0. Epub 2017 Jul 15.

Canada is expected to see an increase in fire risk under future climate projections. Large fires, such as that near Fort McMurray, Alberta in 2016, can be devastating to the communities affected. Understanding the role of human emissions in...

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Kirchmeier-Young MC, Zwiers FW, Gillett NP, et al. Attributing extreme fire risk in Western Canada to human emissions. Clim Change. 2017;144(2):365-379doi: 10.1007/s10584-017-2030-0.
Kirchmeier-Young, M. C., Zwiers, F. W., Gillett, N. P., & Cannon, A. J. (2017). Attributing extreme fire risk in Western Canada to human emissions. Climatic change, 144(2), 365-379. https://doi.org/10.1007/s10584-017-2030-0
Kirchmeier-Young, Megan C, et al. "Attributing extreme fire risk in Western Canada to human emissions." Climatic change vol. 144,2 (2017): 365-379. doi: https://doi.org/10.1007/s10584-017-2030-0
Kirchmeier-Young MC, Zwiers FW, Gillett NP, Cannon AJ. Attributing extreme fire risk in Western Canada to human emissions. Clim Change. 2017;144(2):365-379. doi: 10.1007/s10584-017-2030-0. Epub 2017 Jul 15. PMID: 32009687; PMCID: PMC6961511.
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Cerebral Amyloid Angiopathy Is Associated With Emotional Dysregulation, Impulse Dyscontrol, and Apathy.

Journal of the American Heart Association

Smith EE, Crites S, Wang M, Charlton A, Zwiers A, Sekhon R, Sajobi T, Camicioli R, McCreary CR, Frayne R, Ismail Z.
PMID: 34755541
J Am Heart Assoc. 2021 Nov 16;10(22):e022089. doi: 10.1161/JAHA.121.022089. Epub 2021 Nov 10.

Background Cerebral amyloid angiopathy (CAA) causes cognitive decline, but it is not known whether it is associated with neuropsychiatric symptoms (NPS). Methods and Results Participants with CAA, mild cognitive impairment, mild dementia due to Alzheimer's disease, and normal cognition...

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Smith EE, Crites S, Wang M, et al. Cerebral Amyloid Angiopathy Is Associated With Emotional Dysregulation, Impulse Dyscontrol, and Apathy. J Am Heart Assoc. 2021;10(22):e022089doi: 10.1161/JAHA.121.022089.
Smith, E. E., Crites, S., Wang, M., Charlton, A., Zwiers, A., Sekhon, R., Sajobi, T., Camicioli, R., McCreary, C. R., Frayne, R., & Ismail, Z. (2021). Cerebral Amyloid Angiopathy Is Associated With Emotional Dysregulation, Impulse Dyscontrol, and Apathy. Journal of the American Heart Association, 10(22), e022089. https://doi.org/10.1161/JAHA.121.022089
Smith, Eric E, et al. "Cerebral Amyloid Angiopathy Is Associated With Emotional Dysregulation, Impulse Dyscontrol, and Apathy." Journal of the American Heart Association vol. 10,22 (2021): e022089. doi: https://doi.org/10.1161/JAHA.121.022089
Smith EE, Crites S, Wang M, Charlton A, Zwiers A, Sekhon R, Sajobi T, Camicioli R, McCreary CR, Frayne R, Ismail Z. Cerebral Amyloid Angiopathy Is Associated With Emotional Dysregulation, Impulse Dyscontrol, and Apathy. J Am Heart Assoc. 2021 Nov 16;10(22):e022089. doi: 10.1161/JAHA.121.022089. Epub 2021 Nov 10. PMID: 34755541.
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101 .

Studies in mycology

Haridas S, Albert R, Binder M, Bloem J, LaButti K, Salamov A, Andreopoulos B, Baker SE, Barry K, Bills G, Bluhm BH, Cannon C, Castanera R, Culley DE, Daum C, Ezra D, González JB, Henrissat B, Kuo A, Liang C, Lipzen A, Lutzoni F, Magnuson J, Mondo SJ, Nolan M, Ohm RA, Pangilinan J, Park HJ, Ramírez L, Alfaro M, Sun H, Tritt A, Yoshinaga Y, Zwiers LH, Turgeon BG, Goodwin SB, Spatafora JW, Crous PW, Grigoriev IV.
PMID: 32206138
Stud Mycol. 2020 Feb 01;96:141-153. doi: 10.1016/j.simyco.2020.01.003. eCollection 2020 Jun.

No abstract available.

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Haridas S, Albert R, Binder M, et al. 101 . Stud Mycol. 2020;96:141-153doi: 10.1016/j.simyco.2020.01.003.
Haridas, S., Albert, R., Binder, M., Bloem, J., LaButti, K., Salamov, A., Andreopoulos, B., Baker, S. E., Barry, K., Bills, G., Bluhm, B. H., Cannon, C., Castanera, R., Culley, D. E., Daum, C., Ezra, D., González, J. B., Henrissat, B., Kuo, A., Liang, C., Lipzen, A., Lutzoni, F., Magnuson, J., Mondo, S. J., Nolan, M., Ohm, R. A., Pangilinan, J., Park, H. J., Ramírez, L., Alfaro, M., Sun, H., Tritt, A., Yoshinaga, Y., Zwiers, L. H., Turgeon, B. G., Goodwin, S. B., Spatafora, J. W., Crous, P. W., & Grigoriev, I. V. (2020). 101 . Studies in mycology, 96141-153. https://doi.org/10.1016/j.simyco.2020.01.003
Haridas, S, et al. "101 ." Studies in mycology vol. 96 (2020): 141-153. doi: https://doi.org/10.1016/j.simyco.2020.01.003
Haridas S, Albert R, Binder M, Bloem J, LaButti K, Salamov A, Andreopoulos B, Baker SE, Barry K, Bills G, Bluhm BH, Cannon C, Castanera R, Culley DE, Daum C, Ezra D, González JB, Henrissat B, Kuo A, Liang C, Lipzen A, Lutzoni F, Magnuson J, Mondo SJ, Nolan M, Ohm RA, Pangilinan J, Park HJ, Ramírez L, Alfaro M, Sun H, Tritt A, Yoshinaga Y, Zwiers LH, Turgeon BG, Goodwin SB, Spatafora JW, Crous PW, Grigoriev IV. 101 . Stud Mycol. 2020 Feb 01;96:141-153. doi: 10.1016/j.simyco.2020.01.003. eCollection 2020 Jun. PMID: 32206138; PMCID: PMC7082219.
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A Suite of Tutorials for the WESTPA Rare-Events Sampling Software [Article v1.0].

Living journal of computational molecular science

Bogetti AT, Mostofian B, Dickson A, Pratt AJ, Saglam AS, Harrison PO, Adelman JL, Dudek M, Torrillo PA, DeGrave AJ, Adhikari U, Zwier MC, Zuckerman DM, Chong LT.
PMID: 32395705
Living J Comput Mol Sci. 2019;1(2). doi: 10.33011/livecoms.1.2.10607. Epub 2019 Oct 04.

The weighted ensemble (WE) strategy has been demonstrated to be highly efficient in generating pathways and rate constants for rare events such as protein folding and protein binding using atomistic molecular dynamics simulations. Here we present five tutorials instructing...

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Bogetti AT, Mostofian B, Dickson A, et al. A Suite of Tutorials for the WESTPA Rare-Events Sampling Software [Article v1.0]. Living J Comput Mol Sci. 2019;1(2)doi: 10.33011/livecoms.1.2.10607.
Bogetti, A. T., Mostofian, B., Dickson, A., Pratt, A. J., Saglam, A. S., Harrison, P. O., Adelman, J. L., Dudek, M., Torrillo, P. A., DeGrave, A. J., Adhikari, U., Zwier, M. C., Zuckerman, D. M., & Chong, L. T. (2019). A Suite of Tutorials for the WESTPA Rare-Events Sampling Software [Article v1.0]. Living journal of computational molecular science, 1(2), . https://doi.org/10.33011/livecoms.1.2.10607
Bogetti, Anthony T, et al. "A Suite of Tutorials for the WESTPA Rare-Events Sampling Software [Article v1.0]." Living journal of computational molecular science vol. 1,2 (2019). doi: https://doi.org/10.33011/livecoms.1.2.10607
Bogetti AT, Mostofian B, Dickson A, Pratt AJ, Saglam AS, Harrison PO, Adelman JL, Dudek M, Torrillo PA, DeGrave AJ, Adhikari U, Zwier MC, Zuckerman DM, Chong LT. A Suite of Tutorials for the WESTPA Rare-Events Sampling Software [Article v1.0]. Living J Comput Mol Sci. 2019;1(2). doi: 10.33011/livecoms.1.2.10607. Epub 2019 Oct 04. PMID: 32395705; PMCID: PMC7213600.
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The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces - ERRATUM.

Psychological medicine

Aggensteiner PM, Holz NE, Böttinger BW, Baumeister S, Hohmann S, Werhahn JE, Naaijen J, Ilbegi S, Glennon JC, Hoekstra PJ, Dietrich A, Deters RK, Saam MC, Schulze UME, Lythgoe DJ, Sethi A, Craig MC, Mastroianni M, Sagar-Ouriaghli I, Santosh PJ, Rosa M, Bargallo N, Castro-Fornieles J, Arango C, Penzol MJ, Vidal J, Franke B, Zwiers MP, Buitelaar JK, Walitza S, Banaschewski T, Brandeis D.
PMID: 32854789
Psychol Med. 2020 Aug 28;1. doi: 10.1017/S0033291720003049. Epub 2020 Aug 28.

No abstract available.

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Aggensteiner PM, Holz NE, Böttinger BW, et al. The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces - ERRATUM. Psychol Med. 2020;1doi: 10.1017/S0033291720003049.
Aggensteiner, P. M., Holz, N. E., Böttinger, B. W., Baumeister, S., Hohmann, S., Werhahn, J. E., Naaijen, J., Ilbegi, S., Glennon, J. C., Hoekstra, P. J., Dietrich, A., Deters, R. K., Saam, M. C., Schulze, U. M. E., Lythgoe, D. J., Sethi, A., Craig, M. C., Mastroianni, M., Sagar-Ouriaghli, I., Santosh, P. J., Rosa, M., Bargallo, N., Castro-Fornieles, J., Arango, C., Penzol, M. J., Vidal, J., Franke, B., Zwiers, M. P., Buitelaar, J. K., Walitza, S., Banaschewski, T., & Brandeis, D. (2020). The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces - ERRATUM. Psychological medicine, 1. https://doi.org/10.1017/S0033291720003049
Aggensteiner, Pascal-M, et al. "The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces - ERRATUM." Psychological medicine vol. (2020): 1. doi: https://doi.org/10.1017/S0033291720003049
Aggensteiner PM, Holz NE, Böttinger BW, Baumeister S, Hohmann S, Werhahn JE, Naaijen J, Ilbegi S, Glennon JC, Hoekstra PJ, Dietrich A, Deters RK, Saam MC, Schulze UME, Lythgoe DJ, Sethi A, Craig MC, Mastroianni M, Sagar-Ouriaghli I, Santosh PJ, Rosa M, Bargallo N, Castro-Fornieles J, Arango C, Penzol MJ, Vidal J, Franke B, Zwiers MP, Buitelaar JK, Walitza S, Banaschewski T, Brandeis D. The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces - ERRATUM. Psychol Med. 2020 Aug 28;1. doi: 10.1017/S0033291720003049. Epub 2020 Aug 28. PMID: 32854789.
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White Matter Microstructure in Attention-Deficit/Hyperactivity Disorder: A Systematic Tractography Study in 654 Individuals.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Damatac CG, Chauvin RJM, Zwiers MP, van Rooij D, Akkermans SEA, Naaijen J, Hoekstra PJ, Hartman CA, Oosterlaan J, Franke B, Buitelaar JK, Beckmann CF, Sprooten E.
PMID: 33054990
Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Aug 01; doi: 10.1016/j.bpsc.2020.07.015. Epub 2020 Aug 01.

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by age-inappropriate levels of inattention and/or hyperactivity-impulsivity. ADHD has been related to differences in white matter (WM) microstructure. However, much remains unclear regarding the nature of these WM differences and...

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Damatac CG, Chauvin RJM, Zwiers MP, et al. White Matter Microstructure in Attention-Deficit/Hyperactivity Disorder: A Systematic Tractography Study in 654 Individuals. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;doi: 10.1016/j.bpsc.2020.07.015.
Damatac, C. G., Chauvin, R. J. M., Zwiers, M. P., van Rooij, D., Akkermans, S. E. A., Naaijen, J., Hoekstra, P. J., Hartman, C. A., Oosterlaan, J., Franke, B., Buitelaar, J. K., Beckmann, C. F., & Sprooten, E. (2020). White Matter Microstructure in Attention-Deficit/Hyperactivity Disorder: A Systematic Tractography Study in 654 Individuals. Biological psychiatry. Cognitive neuroscience and neuroimaging, . https://doi.org/10.1016/j.bpsc.2020.07.015
Damatac, Christienne G, et al. "White Matter Microstructure in Attention-Deficit/Hyperactivity Disorder: A Systematic Tractography Study in 654 Individuals." Biological psychiatry. Cognitive neuroscience and neuroimaging vol. (2020). doi: https://doi.org/10.1016/j.bpsc.2020.07.015
Damatac CG, Chauvin RJM, Zwiers MP, van Rooij D, Akkermans SEA, Naaijen J, Hoekstra PJ, Hartman CA, Oosterlaan J, Franke B, Buitelaar JK, Beckmann CF, Sprooten E. White Matter Microstructure in Attention-Deficit/Hyperactivity Disorder: A Systematic Tractography Study in 654 Individuals. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Aug 01; doi: 10.1016/j.bpsc.2020.07.015. Epub 2020 Aug 01. PMID: 33054990.
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Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions.

Journal of lipid research

Boer DE, Mirzaian M, Ferraz MJ, Zwiers KC, Baks MV, Hazeu MD, Ottenhoff R, Marques ARA, Meijer R, Roos JCP, Cox TM, Boot RG, Pannu N, Overkleeft HS, Artola M, Aerts JM.
PMID: 33361282
J Lipid Res. 2021;62:100018. doi: 10.1194/jlr.RA120001043. Epub 2021 Jan 06.

Deficiency of glucocerebrosidase (GBA), a lysosomal β-glucosidase, causes Gaucher disease. The enzyme hydrolyzes β-glucosidic substrates and transglucosylates cholesterol to cholesterol-β-glucoside. Here we show that recombinant human GBA also cleaves β-xylosides and transxylosylates cholesterol. The xylosyl-cholesterol formed acts as an...

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Boer DE, Mirzaian M, Ferraz MJ, et al. Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions. J Lipid Res. 2021;62:100018doi: 10.1194/jlr.RA120001043.
Boer, D. E., Mirzaian, M., Ferraz, M. J., Zwiers, K. C., Baks, M. V., Hazeu, M. D., Ottenhoff, R., Marques, A. R. A., Meijer, R., Roos, J. C. P., Cox, T. M., Boot, R. G., Pannu, N., Overkleeft, H. S., Artola, M., & Aerts, J. M. (2021). Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions. Journal of lipid research, 62100018. https://doi.org/10.1194/jlr.RA120001043
Boer, Daphne E, et al. "Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions." Journal of lipid research vol. 62 (2021): 100018. doi: https://doi.org/10.1194/jlr.RA120001043
Boer DE, Mirzaian M, Ferraz MJ, Zwiers KC, Baks MV, Hazeu MD, Ottenhoff R, Marques ARA, Meijer R, Roos JCP, Cox TM, Boot RG, Pannu N, Overkleeft HS, Artola M, Aerts JM. Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions. J Lipid Res. 2021;62:100018. doi: 10.1194/jlr.RA120001043. Epub 2021 Jan 06. PMID: 33361282; PMCID: PMC7903134.
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Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions.

Journal of lipid research

Boer DE, Mirzaian M, Ferraz MJ, Zwiers KC, Baks MV, Hazeu MD, Ottenhoff R, Marques ARA, Meijer R, Roos JCP, Cox TM, Boot RG, Pannu N, Overkleeft HS, Artola M, Aerts JM.
PMID: 33361282
J Lipid Res. 2021 Jan 06;62:100018. doi: 10.1194/jlr.RA120001043. Epub 2021 Jan 06.

Deficiency of glucocerebrosidase (GBA), a lysosomal β-glucosidase, causes Gaucher disease. The enzyme hydrolyzes β-glucosidic substrates and transglucosylates cholesterol to cholesterol-β-glucoside. Here we show that recombinant human GBA also cleaves β-xylosides and transxylosylates cholesterol. The xylosyl-cholesterol formed acts as an...

Cite
Boer DE, Mirzaian M, Ferraz MJ, et al. Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions. J Lipid Res. 2021;62:100018doi: 10.1194/jlr.RA120001043.
Boer, D. E., Mirzaian, M., Ferraz, M. J., Zwiers, K. C., Baks, M. V., Hazeu, M. D., Ottenhoff, R., Marques, A. R. A., Meijer, R., Roos, J. C. P., Cox, T. M., Boot, R. G., Pannu, N., Overkleeft, H. S., Artola, M., & Aerts, J. M. (2021). Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions. Journal of lipid research, 62100018. https://doi.org/10.1194/jlr.RA120001043
Boer, Daphne E, et al. "Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions." Journal of lipid research vol. 62 (2021): 100018. doi: https://doi.org/10.1194/jlr.RA120001043
Boer DE, Mirzaian M, Ferraz MJ, Zwiers KC, Baks MV, Hazeu MD, Ottenhoff R, Marques ARA, Meijer R, Roos JCP, Cox TM, Boot RG, Pannu N, Overkleeft HS, Artola M, Aerts JM. Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions. J Lipid Res. 2021 Jan 06;62:100018. doi: 10.1194/jlr.RA120001043. Epub 2021 Jan 06. PMID: 33361282; PMCID: PMC7903134.
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