Display options
Cite
Franklin S, Vondriska TM. Genomes, proteomes, and the central dogma. Circ Cardiovasc Genet. 2011;4(5):576doi: 10.1161/CIRCGENETICS.110.957795.
Franklin, S., & Vondriska, T. M. (2011). Genomes, proteomes, and the central dogma. Circulation. Cardiovascular genetics, 4(5), 576. https://doi.org/10.1161/CIRCGENETICS.110.957795
Franklin, Sarah, and Vondriska, Thomas M. "Genomes, proteomes, and the central dogma." Circulation. Cardiovascular genetics vol. 4,5 (2011): 576. doi: https://doi.org/10.1161/CIRCGENETICS.110.957795
Franklin S, Vondriska TM. Genomes, proteomes, and the central dogma. Circ Cardiovasc Genet. 2011 Oct;4(5):576. doi: 10.1161/CIRCGENETICS.110.957795. PMID: 22010165; PMCID: PMC3200573.
Copy Download .nbib Format: NLM
Share it on

Circ Cardiovasc Genet. 2011 Oct;4(5):576. doi: 10.1161/CIRCGENETICS.110.957795.

Genomes, proteomes, and the central dogma.

Circulation. Cardiovascular genetics

Sarah Franklin, Thomas M Vondriska

Affiliations

  1. Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. [email protected]

PMID: 22010165 PMCID: PMC3200573 DOI: 10.1161/CIRCGENETICS.110.957795

Abstract

Systems biology, with its associated technologies of proteomics, genomics, and metabolomics, is driving the evolution of our understanding of cardiovascular physiology. Rather than studying individual molecules or even single reactions, a systems approach allows integration of orthogonal data sets from distinct tiers of biological data, including gene, RNA, protein, metabolite, and other component networks. Together these networks give rise to emergent properties of cellular function, and it is their reprogramming that causes disease. We present 5 observations regarding how systems biology is guiding a revisiting of the central dogma: (1) It deemphasizes the unidirectional flow of information from genes to proteins; (2) it reveals the role of modules of molecules as opposed to individual proteins acting in isolation; (3) it enables discovery of novel emergent properties; (4) it demonstrates the importance of networks in biology; and (5) it adds new dimensionality to the study of biological systems.

References

  1. Science. 2005 Aug 12;309(5737):1078-83 - PubMed
  2. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6544-9 - PubMed
  3. Physiol Rev. 2010 Oct;90(4):1507-46 - PubMed
  4. Cell. 2006 Apr 7;125(1):187-99 - PubMed
  5. Nature. 1999 Dec 2;402(6761 Suppl):C47-52 - PubMed
  6. Circ Res. 2011 Jan 7;108(1):98-112 - PubMed
  7. Circulation. 2010 Jan 5;121(1):157-70 - PubMed
  8. Nat Biotechnol. 2010 Oct;28(10):1079-88 - PubMed
  9. Nat Rev Genet. 2010 Aug;11(8):559-71 - PubMed
  10. Circ Res. 2010 Jun 11;106(11):1681-91 - PubMed
  11. Cell. 2007 Feb 23;128(4):693-705 - PubMed
  12. Circ Res. 2011 Jan 7;108(1):85-97 - PubMed
  13. Science. 2010 Apr 9;328(5975):235-9 - PubMed
  14. Physiol Genomics. 2009 Jul 9;38(2):125-37 - PubMed
  15. Cell. 2000 Oct 13;103(2):193-200 - PubMed
  16. Science. 2009 Oct 9;326(5950):289-93 - PubMed
  17. Nat Biotechnol. 2010 Oct;28(10):1089-95 - PubMed
  18. Physiol Genomics. 2003 Oct 17;15(2):105-14 - PubMed
  19. Nature. 2010 Oct 28;467(7319):1061-73 - PubMed
  20. Mol Cell Proteomics. 2011 Jan;10(1):M110.000703 - PubMed
  21. Circ Res. 2010 May 14;106(9):1459-67 - PubMed
  22. Nature. 1970 Aug 8;227(5258):561-3 - PubMed
  23. Nat Rev Genet. 2011 Jan;12(1):56-68 - PubMed
  24. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6 - PubMed
  25. Cell. 2006 Apr 7;125(1):173-86 - PubMed
  26. J Mol Cell Cardiol. 2009 Feb;46(2):130-6 - PubMed
  27. Ann N Y Acad Sci. 2010 Feb;1188:143-52 - PubMed
  28. Nat Rev Mol Cell Biol. 2010 Nov;11(11):789-801 - PubMed
  29. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1128-33 - PubMed
  30. Nat Rev Genet. 2004 Feb;5(2):101-13 - PubMed
  31. Circ Res. 2006 Aug 18;99(4):362-71 - PubMed
  32. Nat Rev Genet. 2010 Nov;11(11):751-60 - PubMed
  33. Circ Res. 2011 Feb 18;108(4):512-26 - PubMed
  34. Cell. 2010 Sep 17;142(6):967-80 - PubMed
  35. Nature. 2010 May 20;465(7296):363-7 - PubMed
  36. Circulation. 2010 Mar 30;121(12):1447-54 - PubMed
  37. FASEB J. 2003 Jan;17(1):1-6 - PubMed
  38. Biophys J. 2006 Aug 15;91(4):1564-89 - PubMed
  39. Science. 2008 Sep 12;321(5895):1493-5 - PubMed
  40. PLoS Genet. 2010 Sep 09;6(9):e1001111 - PubMed
  41. Circ Res. 2006 Sep 29;99(7):706-14 - PubMed
  42. Cell. 2002 Dec 13;111(6):771-8 - PubMed
  43. Nature. 2008 Nov 27;456(7221):470-6 - PubMed
  44. J Mol Cell Cardiol. 2004 May;36(5):643-52 - PubMed
  45. Nat Cell Biol. 2011 Mar;13(3):191-3 - PubMed
  46. Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1434-41 - PubMed
  47. J Biol Chem. 1991 Dec 25;266(36):24613-20 - PubMed
  48. Mol Syst Biol. 2010 Jun 22;6:381 - PubMed
  49. Novartis Found Symp. 2001;239:4-13; discussion 13-5, 45-51 - PubMed
  50. Science. 2010 Apr 30;328(5978):593-9 - PubMed
  51. Nat Rev Genet. 2009 Jan;10(1):57-63 - PubMed
  52. Cell. 2008 Jun 13;133(6):978-93 - PubMed
  53. Nature. 2009 Jun 4;459(7247):708-11 - PubMed
  54. Nat Methods. 2009 Jan;6(1):83-90 - PubMed
  55. Proteomics. 2010 Jun;10(11):2214-23 - PubMed
  56. Nat Methods. 2008 Apr;5(4):319-22 - PubMed
  57. Cell. 2003 Nov 26;115(5):629-40 - PubMed
  58. Physiol Genomics. 2008 Mar 14;33(1):12-7 - PubMed
  59. Science. 2007 Apr 27;316(5824):575-9 - PubMed
  60. Cell. 2011 Jan 21;144(2):175-86 - PubMed
  61. Nat Methods. 2007 Oct;4(10):817-21 - PubMed
  62. Mol Cell. 2007 Dec 14;28(5):755-60 - PubMed
  63. Circ Res. 2003 May 16;92(9):962-8 - PubMed
  64. Nat Med. 2004 May;10(5):467-74 - PubMed
  65. Nat Biotechnol. 2003 Mar;21(3):281-6 - PubMed
  66. Nature. 2011 Feb 3;470(7332):59-65 - PubMed
  67. Cell. 2007 Jul 27;130(2):247-58 - PubMed
  68. Nat Methods. 2010 Jan;7(1):43-6 - PubMed
  69. Circ Res. 2001 Jan 19;88(1):59-62 - PubMed
  70. Science. 2010 Apr 30;328(5978):636-9 - PubMed
  71. Proteomics. 2008 Apr;8(8):1564-75 - PubMed
  72. Genome Res. 2010 Feb;20(2):281-90 - PubMed
  73. Structure. 2010 Oct 13;18(10):1233-43 - PubMed
  74. Cell. 2010 Oct 15;143(2):212-24 - PubMed
  75. Science. 2003 Oct 10;302(5643):249-55 - PubMed
  76. Nat Rev Mol Cell Biol. 2005 Sep;6(9):702-14 - PubMed
  77. Trends Genet. 2009 Aug;25(8):335-43 - PubMed
  78. Nucleic Acids Res. 2011 Jan;39(Database issue):D871-5 - PubMed
  79. Cell. 2010 Oct 15;143(2):326-e1 - PubMed
  80. Phys Biol. 2009 Feb 25;6(1):016007 - PubMed
  81. Nature. 2001 Mar 8;410(6825):268-76 - PubMed
  82. PLoS One. 2009;4(4):e5206 - PubMed
  83. Nature. 2008 Feb 21;451(7181):949-52 - PubMed
  84. Curr Opin Cell Biol. 2002 Apr;14(2):140-8 - PubMed
  85. FEBS Lett. 2011 Jul 7;585(13):2032-40 - PubMed
  86. Nat Rev Mol Cell Biol. 2010 Jun;11(6):427-39 - PubMed

MeSH terms

Publication Types

Grant support