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Reul JM, Holsboer F. On the role of corticotropin-releasing hormone receptors in anxiety and depression. Dialogues Clin Neurosci. 2002;4(1):31-46
Reul, J. M., & Holsboer, F. (2002). On the role of corticotropin-releasing hormone receptors in anxiety and depression. Dialogues in clinical neuroscience, 4(1), 31-46.
Reul, Johannes M H M, and Holsboer, Florian. "On the role of corticotropin-releasing hormone receptors in anxiety and depression." Dialogues in clinical neuroscience vol. 4,1 (2002): 31-46.
Reul JM, Holsboer F. On the role of corticotropin-releasing hormone receptors in anxiety and depression. Dialogues Clin Neurosci. 2002 Mar;4(1):31-46. PMID: 22033745; PMCID: PMC3181666.
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Dialogues Clin Neurosci. 2002 Mar;4(1):31-46.

On the role of corticotropin-releasing hormone receptors in anxiety and depression.

Dialogues in clinical neuroscience

Johannes M H M Reul, Florian Holsboer

Affiliations

  1. Max Planck Institute of Psychiatry, Munich, Germany.

PMID: 22033745 PMCID: PMC3181666

Abstract

On the basis of extensive basic and clinical studies, corticotropin-releasing hormone (CRH) and its related family members are considered to play a pivotal role in stress-related disorders, such as anxiety and depression. CRH is regarded as the principal mediator in the brain of the stress response, as it mediates neuroendocrine, autonomic, and behavioral responses to stressful challenges. Recently, this neuropeptide family has expanded due to the discovery of two new members, urocortin II (also termed stresscopin-related peptide) and urocortin III (also termed stresscopin), which are selective agonists for the CRH receptor type 2. They show a discrete neuroanatomical localization and are involved in stress-coping responses, such as anxiolysis. Here, on the basis of recent developments, we suggest that CRH, the urocortins, and their receptors form a complex system in the brain, which is recruited during both the acute and the recovery phases of the stress response.

Keywords: antidepressant; anxiety; autonomic nervous system; corticosteroid receptor; corticotropin-releasing hormone; depression; hypothalamic-pituitary-adrenocortical axis; urocortin

References

  1. Peptides. 2001 May;22(5):835-44 - PubMed
  2. Neuropsychopharmacology. 2000 Nov;23(5):477-501 - PubMed
  3. Nat Genet. 2000 Apr;24(4):410-4 - PubMed
  4. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):836-40 - PubMed
  5. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7570-5 - PubMed
  6. Peptides. 2001 May;22(5):743-51 - PubMed
  7. Neuron. 1998 Jun;20(6):1093-102 - PubMed
  8. Brain Res. 2001 Mar 2;893(1-2):29-35 - PubMed
  9. Biol Psychiatry. 1987 Feb;22(2):228-34 - PubMed
  10. Neuroendocrinology. 1988 Jul;48(1):32-8 - PubMed
  11. J Psychiatr Res. 1999 May-Jun;33(3):181-214 - PubMed
  12. Neuropsychopharmacology. 2002 Aug;27(2):194-202 - PubMed
  13. Brain Res. 1999 Jul 17;835(1):18-26 - PubMed
  14. Adv Neuroimmunol. 1995;5(2):127-43 - PubMed
  15. Eur J Neurosci. 2001 Jan;13(2):373-80 - PubMed
  16. Arch Gen Psychiatry. 1988 Jun;45(6):577-9 - PubMed
  17. Endocr Rev. 1998 Jun;19(3):269-301 - PubMed
  18. Annu Rev Neurosci. 1983;6:269-324 - PubMed
  19. Chromosome Res. 2000;8(6):465-76 - PubMed
  20. J Psychiatr Res. 1999 Mar-Apr;33(2):153-63 - PubMed
  21. Bioorg Med Chem Lett. 2000 Apr 17;10(8):707-10 - PubMed
  22. J Psychiatr Res. 2000 May-Jun;34(3):171-81 - PubMed
  23. J Neurosci. 1994 May;14(5 Pt 1):2579-84 - PubMed
  24. Eur J Pharmacol. 2000 Sep 29;405(1-3):199-206 - PubMed
  25. Neuroscience. 1998 Jun;84(4):1025-39 - PubMed
  26. Sleep. 1987 Jun;10(3):199-215 - PubMed
  27. Science. 1984 Dec 14;226(4680):1342-4 - PubMed
  28. Neuroscience. 1998 Aug;85(3):795-805 - PubMed
  29. J Psychiatr Res. 2001 Mar-Apr;35(2):83-94 - PubMed
  30. Peptides. 2001 May;22(5):845-51 - PubMed
  31. Nat Genet. 2000 Apr;24(4):415-9 - PubMed
  32. Nat Neurosci. 1998 Oct;1(6):445-50 - PubMed
  33. Mol Psychiatry. 2001 Sep;6(5):540-6 - PubMed
  34. Nature. 1995 Nov 16;378(6554):287-92 - PubMed
  35. Neuroendocrinology. 2001 May;73(5):293-301 - PubMed
  36. J Clin Endocrinol Metab. 1989 May;68(5):904-11 - PubMed
  37. J Neurosci. 2001 Jul 1;21(13):4822-9 - PubMed
  38. J Neurosci. 1985 Dec;5(12):3189-203 - PubMed
  39. Endocrinology. 2001 Nov;142(11):4946-55 - PubMed
  40. Endocrinology. 1985 Dec;117(6):2505-11 - PubMed
  41. Nat Med. 2001 May;7(5):605-11 - PubMed
  42. J Comp Neurol. 1999 Dec 20;415(3):285-312 - PubMed
  43. Bioorg Med Chem Lett. 2001 Feb 12;11(3):331-3 - PubMed
  44. J Neurosci. 1995 Oct;15(10):6340-50 - PubMed
  45. J Neurosci. 1997 Jun 1;17(11):4448-60 - PubMed
  46. Endocrinology. 1995 Sep;136(9):4139-42 - PubMed
  47. Int J Artif Organs. 1998 Jun;21(6):341-3 - PubMed
  48. Regul Pept. 1995 Oct 20;59(2):229-39 - PubMed
  49. CNS Spectr. 2001 Jul;6(7):590-4 - PubMed
  50. N Engl J Med. 1984 Oct 25;311(17):1127 - PubMed
  51. J Comp Neurol. 2000 Dec 11;428(2):191-212 - PubMed
  52. Int J Pept Protein Res. 1980 Sep;16(3):191-9 - PubMed
  53. Endocrinology. 1995 Oct;136(10):4517-25 - PubMed
  54. J Pharmacol Exp Ther. 1999 May;289(2):926-35 - PubMed
  55. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2843-8 - PubMed
  56. Neuroendocrinology. 1983;36(3):165-86 - PubMed
  57. Endocrinology. 1996 Nov;137(11):4619-29 - PubMed
  58. Peptides. 1999;20(2):211-8 - PubMed
  59. J Neurosci. 2000 Feb 1;20(3):1142-56 - PubMed
  60. Brain Res. 2000 Oct 27;881(2):204-7 - PubMed
  61. Cell. 2001 Aug 10;106(3):367-79 - PubMed
  62. Nat Genet. 2000 Apr;24(4):403-9 - PubMed
  63. J Neurosci. 1999 Jun 15;19(12):5016-25 - PubMed
  64. Proc West Pharmacol Soc. 1982;25:223-7 - PubMed
  65. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8967-71 - PubMed
  66. Arch Gen Psychiatry. 1987 Sep;44(9):775-81 - PubMed
  67. Psychoneuroendocrinology. 1998 Apr;23(3):219-43 - PubMed
  68. J Sleep Res. 1997 Sep;6(3):164-70 - PubMed
  69. Endocrinology. 2000 Nov;141(11):4262-9 - PubMed
  70. Peptides. 2001 May;22(5):753-60 - PubMed
  71. J Neurosci. 2000 Jul 15;20(14):5564-73 - PubMed
  72. Pharmacol Rev. 1991 Dec;43(4):425-73 - PubMed
  73. J Med Chem. 2000 May 4;43(9):1641-60 - PubMed
  74. Biol Psychiatry. 1999 Dec 1;46(11):1480-508 - PubMed
  75. Regul Pept. 1997 Jul 23;71(1):15-21 - PubMed
  76. J Neuroendocrinol. 1994 Dec;6(6):689-96 - PubMed
  77. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8777-81 - PubMed
  78. J Neurosci. 1995 Apr;15(4):2680-95 - PubMed
  79. Synapse. 1996 May;23(1):28-38 - PubMed
  80. Eur J Pharmacol. 2000 Sep 29;405(1-3):235-49 - PubMed
  81. Neuroscience. 2002;109(2):253-66 - PubMed
  82. Endocrinology. 1999 Jan;140(1):79-86 - PubMed
  83. Baillieres Best Pract Res Clin Endocrinol Metab. 1999 Dec;13(4):597-614 - PubMed
  84. Trends Endocrinol Metab. 1999 Aug;10(6):236-244 - PubMed
  85. Biol Psychiatry. 1998 Apr 15;43(8):547-73 - PubMed
  86. Science. 1981 Sep 18;213(4514):1394-7 - PubMed
  87. J Med Chem. 2000 Feb 10;43(3):449-56 - PubMed
  88. Nat Genet. 1998 Jun;19(2):162-6 - PubMed
  89. Neuroendocrinology. 1986;42(6):467-74 - PubMed

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