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Nuzzo F, Casati A, Raimondi E. Non random distribution of lesions induced by deoxyribonuclease I in human chromosomes. Cytotechnology. 1987;1(1):19-24doi: 10.1007/BF00351117.
Nuzzo, F., Casati, A., & Raimondi, E. (1987). Non random distribution of lesions induced by deoxyribonuclease I in human chromosomes. Cytotechnology, 1(1), 19-24. https://doi.org/10.1007/BF00351117
Nuzzo, F, et al. "Non random distribution of lesions induced by deoxyribonuclease I in human chromosomes." Cytotechnology vol. 1,1 (1987): 19-24. doi: https://doi.org/10.1007/BF00351117
Nuzzo F, Casati A, Raimondi E. Non random distribution of lesions induced by deoxyribonuclease I in human chromosomes. Cytotechnology. 1987 Oct;1(1):19-24. doi: 10.1007/BF00351117. PMID: 22358435.
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Cytotechnology. 1987 Oct;1(1):19-24. doi: 10.1007/BF00351117.

Non random distribution of lesions induced by deoxyribonuclease I in human chromosomes.

Cytotechnology

F Nuzzo, A Casati, E Raimondi

Affiliations

  1. Instituto di Genetica Biochimica ed Evoluzionistica del C.N.R., Via Abbiategrasso 207, I-27100, Pavia, Italy.

PMID: 22358435 DOI: 10.1007/BF00351117

Abstract

We studied the action of deoxyribonuclease I on human lymphocytes in order to determine the localization of the DNAase induced aberrations. Our results indicate a non-random distribution of the lesions on chromosome regions which may reflect a differential pattern of sensitivity to the enzyme. Furthermore we observed a correspondence between the preferential DNAase induced breaks and fragile sites that are expressed in lymphocytes maintained in medium without folic acid. A possible interpretation of our findings is that the accessibility to DNAase and/or the efficiency of the repair systems depend on the chromatin structure that influences also the expression of some common fragile sites.

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