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Shafy A, Molinié V, Cortes-Morichetti M, et al. Comparison of the effects of adenosine, inosine, and their combination as an adjunct to reperfusion in the treatment of acute myocardial infarction. ISRN Cardiol. 2012;2012:326809doi: 10.5402/2012/326809.
Shafy, A., Molinié, V., Cortes-Morichetti, M., Hupertan, V., Lila, N., & Chachques, J. C. (2012). Comparison of the effects of adenosine, inosine, and their combination as an adjunct to reperfusion in the treatment of acute myocardial infarction. ISRN cardiology, 2012326809. https://doi.org/10.5402/2012/326809
Shafy, Abdel, et al. "Comparison of the effects of adenosine, inosine, and their combination as an adjunct to reperfusion in the treatment of acute myocardial infarction." ISRN cardiology vol. 2012 (2012): 326809. doi: https://doi.org/10.5402/2012/326809
Shafy A, Molinié V, Cortes-Morichetti M, Hupertan V, Lila N, Chachques JC. Comparison of the effects of adenosine, inosine, and their combination as an adjunct to reperfusion in the treatment of acute myocardial infarction. ISRN Cardiol. 2012;2012:326809. doi: 10.5402/2012/326809. Epub 2012 Mar 14. PMID: 22462024; PMCID: PMC3312546.
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ISRN Cardiol. 2012;2012:326809. doi: 10.5402/2012/326809. Epub 2012 Mar 14.

Comparison of the effects of adenosine, inosine, and their combination as an adjunct to reperfusion in the treatment of acute myocardial infarction.

ISRN cardiology

Abdel Shafy, Vincent Molinié, Miguel Cortes-Morichetti, Vincent Hupertan, Nermine Lila, Juan C Chachques

Affiliations

  1. Laboratory of Biosurgical Research, Alain Carpentier Foundation, University Paris Descartes, 75015 Paris, France.

PMID: 22462024 PMCID: PMC3312546 DOI: 10.5402/2012/326809

Abstract

Adenosine and inosine are both key intracellular energy substrates for nucleotide synthesis by salvage pathways, especially during ischemic stress conditions. Additionally they both possess cell protective and cell repair properties. The objective of this study is to detect potential advantages of the combination of adenosine and inosine versus each drug alone, in terms of ventricular function, infarct size reduction and angiogenesis. Myocardial ischemia was created in rodents and treated with adenosine, inosine or their combination. Results of experiments showed that the combination of both drugs significantly reduced infarct size and improved myocardial angiogenesis and ventricular function. The two compounds, while chemically similar, use different intracellular pathways, allowing for complementary biological activities without overlapping. The drug combination at specific 1 : 5 adenosine : inosine dose ratio demonstrated positive cardiologic effects, deserving further evaluation as an adjunct to reperfusion techniques during and after acute coronary syndrome. The association of adenosine and inosine may contribute to reduce myocardial infarction morbidity and mortality rates.

References

  1. Am J Cardiol. 2004 Jul 1;94(1):9-13 - PubMed
  2. Am J Physiol Heart Circ Physiol. 2003 Nov;285(5):H1797-818 - PubMed
  3. Cephalalgia. 2005 May;25(5):369-77 - PubMed
  4. Mayo Clin Proc. 1995 Apr;70(4):331-6 - PubMed
  5. Circulation. 1983 Dec;68(6):1254-63 - PubMed
  6. J Pharmacol. 1983;14 Suppl 3:47-71 - PubMed
  7. Jpn Heart J. 1981 Nov;22(6):915-28 - PubMed
  8. Nature. 2001 Dec 20-27;414(6866):916-20 - PubMed
  9. Expert Opin Investig Drugs. 2000 Nov;9(11):2519-35 - PubMed
  10. BMC Physiol. 2005 Jun 20;5:10 - PubMed
  11. Circulation. 2000 Aug 15;102(7):800-5 - PubMed
  12. Cardiovasc Res. 1995 Apr;29(4):495-505 - PubMed
  13. Arterioscler Thromb Vasc Biol. 2000 May;20(5):1250-6 - PubMed
  14. Stroke. 1995 Sep;26(9):1572-6 - PubMed
  15. Eur Heart J. 2006 Oct;27(20):2400-5 - PubMed
  16. Cell Physiol Biochem. 2007;20(1-4):1-22 - PubMed
  17. Circ Cardiovasc Interv. 2009 Aug;2(4):323-9 - PubMed
  18. J Am Coll Cardiol. 1999 Nov 15;34(6):1711-20 - PubMed
  19. Hypertension. 1986 May;8(5):391-8 - PubMed
  20. J Immunol. 2000 Jan 15;164(2):1013-9 - PubMed
  21. Curr Surg. 1985 Nov-Dec;42(6):469-71 - PubMed
  22. Eur J Clin Pharmacol. 2003 May;59(1):1-9 - PubMed
  23. Acta Anaesthesiol Scand. 2000 Oct;44(9):1038-55 - PubMed
  24. Int J Biochem Cell Biol. 2005 Apr;37(4):797-808 - PubMed
  25. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13486-90 - PubMed
  26. J Biol Chem. 2000 Mar 24;275(12):8375-81 - PubMed
  27. J Appl Physiol (1985). 1994 Jan;76(1):5-13 - PubMed
  28. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H637-42 - PubMed
  29. J Nucl Cardiol. 2007 May-Jun;14(3):415-6 - PubMed
  30. Jpn J Pharmacol. 1990 May;53(1):1-9 - PubMed
  31. Biomed Biochim Acta. 1985;44(3):493-5 - PubMed
  32. Am J Physiol. 1980 Apr;238(4):H569-74 - PubMed
  33. Circ Res. 2006 Mar 17;98(5):e39-47 - PubMed
  34. Am J Physiol Regul Integr Comp Physiol. 2005 Aug;289(2):R283-R296 - PubMed
  35. Am J Physiol. 1977 Oct;233(4):H438-43 - PubMed
  36. N Engl J Med. 2007 Sep 13;357(11):1121-35 - PubMed
  37. Vrach Delo. 1986 Aug;(8):17-9 - PubMed
  38. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9031-6 - PubMed
  39. J Am Coll Cardiol. 2005 Jun 7;45(11):1775-80 - PubMed
  40. J Am Coll Cardiol. 2000 Jan;35(1):238-45 - PubMed
  41. Clin Physiol. 1989 Feb;9(1):27-38 - PubMed

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