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Umekawa M, Klionsky DJ. The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective. Int J Cell Biol. 2012;2012:142634doi: 10.1155/2012/142634.
Umekawa, M., & Klionsky, D. J. (2012). The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective. International journal of cell biology, 2012142634. https://doi.org/10.1155/2012/142634
Umekawa, Midori, and Klionsky, Daniel J. "The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective." International journal of cell biology vol. 2012 (2012): 142634. doi: https://doi.org/10.1155/2012/142634
Umekawa M, Klionsky DJ. The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective. Int J Cell Biol. 2012;2012:142634. doi: 10.1155/2012/142634. Epub 2012 Feb 20. PMID: 22481942; PMCID: PMC3296166.
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Int J Cell Biol. 2012;2012:142634. doi: 10.1155/2012/142634. Epub 2012 Feb 20.

The Cytoplasm-to-Vacuole Targeting Pathway: A Historical Perspective.

International journal of cell biology

Midori Umekawa, Daniel J Klionsky

Affiliations

  1. Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.

PMID: 22481942 PMCID: PMC3296166 DOI: 10.1155/2012/142634

Abstract

From today's perspective, it is obvious that macroautophagy (hereafter autophagy) is an important pathway that is connected to a range of developmental and physiological processes. This viewpoint, however, is relatively recent, coinciding with the molecular identification of autophagy-related (Atg) components that function as the protein machinery that drives the dynamic membrane events of autophagy. It may be difficult, especially for scientists new to this area of research, to appreciate that the field of autophagy long existed as a "backwater" topic that attracted little interest or attention. Paralleling the development of the autophagy field was the identification and analysis of the cytoplasm-to-vacuole targeting (Cvt) pathway, the only characterized biosynthetic route that utilizes the Atg proteins. Here, we relate some of the initial history, including some never-before-revealed facts, of the analysis of the Cvt pathway and the convergence of those studies with autophagy.

References

  1. FEBS Lett. 1993 Oct 25;333(1-2):169-74 - PubMed
  2. J Cell Biol. 2001 Apr 16;153(2):381-96 - PubMed
  3. J Cell Biol. 1997 May 5;137(3):609-18 - PubMed
  4. J Biol Chem. 1989 Apr 25;264(12):6979-83 - PubMed
  5. FEBS Lett. 1994 Aug 1;349(2):275-80 - PubMed
  6. Mol Cell Biol. 1987 Dec;7(12):4390-9 - PubMed
  7. J Cell Biol. 2000 Feb 7;148(3):465-80 - PubMed
  8. Biochim Biophys Acta. 1976 May 13;429(3):933-49 - PubMed
  9. EMBO J. 2001 Nov 1;20(21):5971-81 - PubMed
  10. Cell. 1986 Dec 26;47(6):1041-51 - PubMed
  11. Mol Biol Cell. 2008 Aug;19(8):3290-8 - PubMed
  12. J Bacteriol. 1983 Oct;156(1):36-48 - PubMed
  13. J Biol Chem. 2002 Jan 4;277(1):763-73 - PubMed
  14. J Cell Biol. 2000 Sep 18;150(6):1507-13 - PubMed
  15. Biochim Biophys Acta. 1983 Oct 13;741(1):128-35 - PubMed
  16. Mol Cell Biol. 1986 Jul;6(7):2500-10 - PubMed
  17. J Cell Biol. 1997 Dec 29;139(7):1687-95 - PubMed
  18. Proc Natl Acad Sci U S A. 1986 Dec;83(23):9075-9 - PubMed
  19. Gene. 1987;58(1):137-48 - PubMed
  20. J Biol Chem. 2008 Nov 21;283(47):32386-93 - PubMed
  21. J Cell Biol. 1994 Mar;124(6):903-13 - PubMed
  22. J Biol Chem. 2011 Apr 15;286(15):13704-13 - PubMed
  23. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12304-8 - PubMed
  24. J Cell Biol. 2006 Dec 18;175(6):925-35 - PubMed
  25. Mol Cell. 2001 Jun;7(6):1131-41 - PubMed
  26. J Cell Biol. 1995 Nov;131(3):591-602 - PubMed
  27. Nature. 2000 Feb 10;403(6770):623-7 - PubMed
  28. J Cell Biol. 2000 Nov 27;151(5):1025-34 - PubMed
  29. J Biol Chem. 1990 Dec 25;265(36):22418-25 - PubMed
  30. Mol Biol Cell. 2001 Dec;12(12):3821-38 - PubMed
  31. Mol Cell Biol. 1986 Jul;6(7):2490-9 - PubMed
  32. Nature. 1998 Sep 24;395(6700):395-8 - PubMed
  33. Autophagy. 2007 Mar-Apr;3(2):106-16 - PubMed
  34. J Biol Chem. 1996 Jul 26;271(30):17621-4 - PubMed
  35. J Biol Chem. 2001 Jun 8;276(23):20491-8 - PubMed
  36. J Biol Chem. 1986 May 25;261(15):6853-9 - PubMed
  37. Dev Cell. 2003 Oct;5(4):539-45 - PubMed
  38. J Biol Chem. 2001 Aug 10;276(32):30442-51 - PubMed
  39. Mol Biol Cell. 2000 Mar;11(3):969-82 - PubMed
  40. Mol Biol Cell. 2005 Dec;16(12):5843-56 - PubMed
  41. J Biol Chem. 2001 Aug 3;276(31):29210-7 - PubMed
  42. J Cell Biol. 1997 Jul 14;138(1):37-44 - PubMed
  43. Mol Biol Cell. 2005 Apr;16(4):1593-605 - PubMed
  44. J Cell Biol. 1996 Mar;132(6):999-1010 - PubMed
  45. J Cell Biol. 1992 Oct;119(2):301-11 - PubMed
  46. Proc Natl Acad Sci U S A. 1987 May;84(9):2585-9 - PubMed
  47. J Biol Chem. 2005 Nov 25;280(47):39067-76 - PubMed
  48. Mol Biol Cell. 2008 May;19(5):1962-75 - PubMed
  49. FEBS Lett. 1989 Dec 18;259(1):125-9 - PubMed
  50. Biochem Biophys Res Commun. 2007 May 4;356(2):405-10 - PubMed
  51. Cell. 1987 Mar 13;48(5):887-97 - PubMed
  52. J Biol Chem. 2003 Nov 28;278(48):48445-52 - PubMed
  53. Biochem Biophys Res Commun. 2005 Dec 30;338(4):1884-9 - PubMed
  54. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4569-74 - PubMed
  55. J Biol Chem. 2000 Aug 18;275(33):25840-9 - PubMed
  56. Mol Cell Biol. 2010 Feb;30(4):1049-58 - PubMed
  57. Biochim Biophys Acta. 1978 Nov 10;527(1):31-41 - PubMed
  58. Dev Cell. 2002 Dec;3(6):825-37 - PubMed
  59. J Cell Biol. 1992 Oct;119(2):287-99 - PubMed
  60. J Biol Chem. 2010 Sep 24;285(39):30019-25 - PubMed
  61. Mol Biol Cell. 2003 Feb;14(2):477-90 - PubMed

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