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Zhou X, Chen Y, Li Y, et al. Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization. Oncol Lett. 2011;3(3):659-661doi: 10.3892/ol.2011.542.
Zhou, X., Chen, Y., Li, Y., & Duan, Z. (2012). Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization. Oncology letters, 3(3), 659-661. https://doi.org/10.3892/ol.2011.542
Zhou, Xi, et al. "Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization." Oncology letters vol. 3,3 (2012): 659-661. doi: https://doi.org/10.3892/ol.2011.542
Zhou X, Chen Y, Li Y, Duan Z. Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization. Oncol Lett. 2012 Mar;3(3):659-661. doi: 10.3892/ol.2011.542. Epub 2011 Dec 28. PMID: 22740971; PMCID: PMC3362542.
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Oncol Lett. 2012 Mar;3(3):659-661. doi: 10.3892/ol.2011.542. Epub 2011 Dec 28.

Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization.

Oncology letters

Xi Zhou, Yongli Chen, Yongmei Li, Zhao Duan

Affiliations

  1. Department of Obstetrics and Gynecology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000.

PMID: 22740971 PMCID: PMC3362542 DOI: 10.3892/ol.2011.542

Abstract

In the present study, the case of a 34-year-old Chinese female who underwent in vitro fertilization resulting in a twin pregnancy was reported. Following in vitro fertilization, the patient was found to have a partial hydatidiform mole (PHM) with a co-existing twin by transvaginal sonography (TVS). At 16 weeks, the pregnancy was terminated and a normal-looking fetus with a HM placenta was delivered, in addition to a normal fetus with a normal placenta. Following termination of the pregnancy, the PHM progressed into an invasive mole with lung metastasis, a rare event. Serum human chorionic gonadotrophin (hCG) concentrations decreased in the first week following delivery, but over the following 21 days hCG levels showed a continuous increase. Following 2 cycles of combinative chemotherapy consisting of fluorouracil (5-FU) and dactinomycin (KSM), hCG concentrations decreased to normal levels. The patient was then administered 1 cycle of repeated chemotherapy and hCG levels remained negative for the following 2 years.

References

  1. J Reprod Med. 2009 Feb;54(2):88-94 - PubMed
  2. Hum Reprod. 2008 Sep;23(9):2031-5 - PubMed
  3. Hum Reprod. 1999 Nov;14(11):2905-7 - PubMed
  4. Am J Obstet Gynecol. 2010 Dec;203(6):531-9 - PubMed
  5. J Obstet Gynaecol Res. 2008 Aug;34(4 Pt 2):641-4 - PubMed
  6. Lancet. 2010 Aug 28;376(9742):717-29 - PubMed
  7. J Reprod Med. 1994 Mar;39(3):168-74 - PubMed
  8. Gynecol Oncol. 1985 Jan;20(1):53-61 - PubMed
  9. Gynecol Oncol. 2000 Sep;78(3 Pt 1):309-12 - PubMed
  10. Lancet. 1976 Jan 31;1(7953):259 - PubMed
  11. Nature. 1977 Aug 18;268(5621):633-4 - PubMed
  12. J Ultrasound Med. 2010 Feb;29(2):271-80 - PubMed
  13. Eur J Obstet Gynecol Reprod Biol. 2009 Apr;143(2):84-7 - PubMed

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