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Zhang X, Cheng B, Jing X, et al. NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21). Evid Based Complement Alternat Med. 2012;2012:583479doi: 10.1155/2012/583479.
Zhang, X., Cheng, B., Jing, X., Qiao, Y., Gao, X., Yu, H., Zhu, B., & Qiao, H. (2012). NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21). Evidence-based complementary and alternative medicine : eCAM, 2012583479. https://doi.org/10.1155/2012/583479
Zhang, Xin, et al. "NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21)." Evidence-based complementary and alternative medicine : eCAM vol. 2012 (2012): 583479. doi: https://doi.org/10.1155/2012/583479
Zhang X, Cheng B, Jing X, Qiao Y, Gao X, Yu H, Zhu B, Qiao H. NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21). Evid Based Complement Alternat Med. 2012;2012:583479. doi: 10.1155/2012/583479. Epub 2012 May 13. PMID: 22654955; PMCID: PMC3359673.
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Evid Based Complement Alternat Med. 2012;2012:583479. doi: 10.1155/2012/583479. Epub 2012 May 13.

NMDA Receptors of Gastric-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus Mediate the Regulation of Gastric Emptying by EA at Weishu (BL21).

Evidence-based complementary and alternative medicine : eCAM

Xin Zhang, Bin Cheng, Xianghong Jing, Yongfa Qiao, Xinyan Gao, Huijuan Yu, Bing Zhu, Haifa Qiao

Affiliations

  1. Neuroscience Program, Shandong University of Traditional Chinese Medicine, Changqing University Park, Jinan 250355, China.

PMID: 22654955 PMCID: PMC3359673 DOI: 10.1155/2012/583479

Abstract

A large number of studies have been conducted to explore the efficacy of electroacupuncture (EA) for the treatment of gastrointestinal motility. While several lines of evidence addressed the basic mechanism of EA on gastrointestinal motility regarding effects of limb and abdomen points, the mechanism for effects of the back points on gastric motility still remains unclear. Here we report that the NMDA receptor (NMDAR) antagonist kynurenic acid inhibited the gastric emptying increase induced by high-intensity EA at BL21 and agonist NMDA enhanced the effect of the same treatment. EA at BL21 enhanced NMDAR, but not AMPA receptor (AMPAR) component of miniature excitatory postsynaptic current (mEPSC) in gastric-projecting neurons of the dorsal motor nucleus of the vagus (DMV). In sum, our data demonstrate an important role of NMDAR-mediated synaptic transmission of gastric-projecting DMV neurons in mediating EA at BL21-induced enhancement of gastric emptying.

References

  1. Gut. 1994 Aug;35(8):1026-9 - PubMed
  2. Eur J Pharmacol. 1999 Mar 5;368(2-3):173-82 - PubMed
  3. Digestion. 2001;64(3):184-90 - PubMed
  4. J Neurosci. 2004 Aug 18;24(33):7344-52 - PubMed
  5. Neurogastroenterol Motil. 1998 Aug;10(4):305-13 - PubMed
  6. World J Gastroenterol. 2007 Feb 7;13(5):709-16 - PubMed
  7. J Neurophysiol. 2002 Jul;88(1):49-63 - PubMed
  8. Auton Neurosci. 2010 Aug 25;156(1-2):15-8 - PubMed
  9. J Physiol. 1999 Jan 15;514 ( Pt 2):369-83 - PubMed
  10. J Gastroenterol. 2006 May;41(5):408-17 - PubMed
  11. Brain Res. 1980 Jan 20;182(1):85-97 - PubMed
  12. Auton Neurosci. 2010 Oct 28;157(1-2):31-7 - PubMed
  13. J Physiol. 1999 Jun 1;517 ( Pt 2):521-32 - PubMed
  14. Aliment Pharmacol Ther. 2004 Oct 15;20(8):831-41 - PubMed
  15. J Comp Neurol. 1997 Jan 6;377(1):49-69 - PubMed
  16. Am J Gastroenterol. 1992 Oct;87(10):1372-81 - PubMed
  17. Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1106-13 - PubMed
  18. Auton Neurosci. 2008 Feb 29;138(1-2):50-6 - PubMed
  19. Gastroenterology. 1984 Jun;86(6):1592-610 - PubMed
  20. Brain Res Bull. 1995;38(6):587-94 - PubMed
  21. Neurosci Lett. 2006 May 15;399(1-2):6-10 - PubMed
  22. Am J Physiol. 1996 Dec;271(6 Pt 2):R1614-9 - PubMed
  23. Gastroenterology. 1995 Nov;109(5):1484-91 - PubMed
  24. Brain Res. 1997 Jul 18;763(1):123-6 - PubMed
  25. Am J Gastroenterol. 1997 Sep;92(9):1527-30 - PubMed
  26. Gastroenterology. 1993 Aug;105(2):433-40 - PubMed
  27. Am J Physiol. 1993 Feb;264(2 Pt 1):G261-71 - PubMed
  28. J Vet Sci. 2000 Dec;1(2):133-8 - PubMed
  29. Nature. 1976 Apr 15;260(5552):622-4 - PubMed
  30. Am J Physiol Regul Integr Comp Physiol. 2001 Nov;281(5):R1522-30 - PubMed
  31. Am J Physiol. 1990 Aug;259(2 Pt 1):G321-6 - PubMed
  32. J Auton Nerv Syst. 1996 Feb 5;57(1-2):22-8 - PubMed

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