PLoS One. 2012;7(7):e39860. doi: 10.1371/journal.pone.0039860. Epub 2012 Jul 06.

MassTRIX reloaded: combined analysis and visualization of transcriptome and metabolome data.

PloS one

Brigitte Wägele, Michael Witting, Philippe Schmitt-Kopplin, Karsten Suhre

PMID: 22815716 PMCID: PMC3391204 DOI: 10.1371/journal.pone.0039860

Abstract

Systems Biology is a field in biological science that focuses on the combination of several or all "omics"-approaches in order to find out how genes, transcripts, proteins and metabolites act together in the network of life. Metabolomics as analog to genomics, transcriptomics and proteomics is more and more integrated into biological studies and often transcriptomic and metabolomic experiments are combined in one setup. At a first glance both data types seem to be completely different, but both produce information on biological entities, either transcripts or metabolites. Both types can be overlaid on metabolic pathways to obtain biological information on the studied system. For the joint analysis of both data types the MassTRIX webserver was updated. MassTRIX is freely available at www.masstrix.org.

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MeSH terms

• Computer Graphics*
• Internet*
• Metabolome*
• Software*
• Statistics as Topic / methods
• Systems Biology
• Transcriptome*

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't