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Avari P, Huang W, Averill S, et al. The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats. Brain Behav. 2012;2(4):402-14doi: 10.1002/brb3.63.
Avari, P., Huang, W., Averill, S., Colom, B., Imhof, B. A., Nourshargh, S., & Priestley, J. V. (2012). The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats. Brain and behavior, 2(4), 402-14. https://doi.org/10.1002/brb3.63
Avari, Parizad, et al. "The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats." Brain and behavior vol. 2,4 (2012): 402-14. doi: https://doi.org/10.1002/brb3.63
Avari P, Huang W, Averill S, Colom B, Imhof BA, Nourshargh S, Priestley JV. The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats. Brain Behav. 2012 Jul;2(4):402-14. doi: 10.1002/brb3.63. PMID: 22950044; PMCID: PMC3432963.
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Brain Behav. 2012 Jul;2(4):402-14. doi: 10.1002/brb3.63.

The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats.

Brain and behavior

Parizad Avari, Wenlong Huang, Sharon Averill, Bartomeu Colom, Beat A Imhof, Sussan Nourshargh, John V Priestley

PMID: 22950044 PMCID: PMC3432963 DOI: 10.1002/brb3.63

Abstract

JAM-C is a junctional adhesion molecule, enriched at tight junctions on endothelial and epithelial cells, and also localized to Schwann cells at junctions between adjoining myelin end loops. The role of JAM-C following peripheral nerve injury (PNI) is currently unknown. We examined the localization of JAM-C after sciatic nerve crush injury in adult rats. JAM-C immunoreactivity was present in paranodes and incisures in sham surgery control nerve, but distal to the crush injury significantly decreased at three and 14 days. JAM-C was re-expressed at 28 days and, by 56 days, was significantly increased in the distal nerve compared to controls. In a 7-mm length of sciatic nerve sampled distal to the crush site, the densities of JAM-C immunoreactive paranodes increased in the distal direction. Conversely, the densities of JAM-C immunoreactive incisures were highest immediately distal to the crush site and decreased in the more distal direction. Further analysis revealed a strong correlation between JAM-C localization and remyelination. Fifty-six days after crush injury, greater densities of JAM-C paranodes were seen compared to the nodal marker jacalin, suggesting that paranodal JAM-C precedes node formation. Our data are the first to demonstrate a potential role of JAM-C in remyelination after PNI.

Keywords: JAM-C; Schwann cells; paranodes; peripheral nerve injury; remyelination

References

  1. Neuron Glia Biol. 2006 May;2(2):69-79 - PubMed
  2. Brain Res. 2004 Nov 19;1027(1-2):67-72 - PubMed
  3. Muscle Nerve. 2008 Jun;37(6):721-30 - PubMed
  4. Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2104-12 - PubMed
  5. Curr Opin Neurol. 1998 Oct;11(5):557-62 - PubMed
  6. J Invest Dermatol. 2005 Nov;125(5):969-76 - PubMed
  7. Nat Neurosci. 2007 Jul;10(7):861-9 - PubMed
  8. J Comp Neurol. 2007 Nov 10;505(2):166-76 - PubMed
  9. FASEB J. 2012 Mar;26(3):1064-76 - PubMed
  10. Anat Rec. 1947 Dec;99(4):447-75 - PubMed
  11. BMC Neurosci. 2005 Feb 01;6:6 - PubMed
  12. Nat Rev Neurosci. 2003 Dec;4(12):968-80 - PubMed
  13. J Neurosci. 1999 Sep 1;19(17):7516-28 - PubMed
  14. J Exp Med. 2006 Nov 27;203(12):2703-14 - PubMed
  15. J Cell Biol. 2008 May 19;181(4):575-7 - PubMed
  16. J Pathol. 2007 Jun;212(2):198-208 - PubMed
  17. Int Rev Neurobiol. 1975;17:241-96 - PubMed
  18. J Anat. 1946 Jan;80(Pt 1):37-50 - PubMed
  19. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1509-15 - PubMed
  20. Annu Rev Neurosci. 1990;13:43-60 - PubMed
  21. Trends Neurosci. 1999 Sep;22(9):402-10 - PubMed
  22. Mol Biol Cell. 2005 Oct;16(10):4992-5003 - PubMed
  23. Cancer Res. 2005 Jul 1;65(13):5703-10 - PubMed
  24. Nat Immunol. 2011 Jun 26;12(8):761-9 - PubMed
  25. Neuroscience. 1990;35(1):157-65 - PubMed
  26. J Immunol. 2005 May 15;174(10):6406-15 - PubMed
  27. J Anat. 2006 Jul;209(1):111-8 - PubMed
  28. Prog Neurobiol. 1994 Jun;43(2):85-141 - PubMed
  29. J Biol Chem. 2001 Dec 7;276(49):45826-32 - PubMed
  30. J Anat. 1968 Sep;103(Pt 2):233-43 - PubMed
  31. J Biol Chem. 2004 Dec 31;279(53):55602-8 - PubMed
  32. J Neurosci. 2004 Mar 31;24(13):3176-85 - PubMed
  33. J Cell Biol. 2005 May 9;169(3):527-38 - PubMed
  34. J Biol Chem. 2001 Jan 26;276(4):2733-41 - PubMed
  35. Nat Rev Immunol. 2007 Jun;7(6):467-77 - PubMed
  36. Neurol Clin. 1992 Aug;10(3):613-27 - PubMed
  37. Neuron. 1995 Sep;15(3):553-62 - PubMed
  38. Curr Opin Cell Biol. 2008 Dec;20(6):616-23 - PubMed
  39. J Immunol. 2002 Feb 15;168(4):1618-26 - PubMed
  40. Nature. 2004 Sep 16;431(7006):320-4 - PubMed
  41. Curr Opin Cell Biol. 2003 Oct;15(5):525-30 - PubMed
  42. Science. 2007 Nov 30;318(5855):1472-5 - PubMed
  43. Neurosurg Focus. 2004 May 15;16(5):E1 - PubMed
  44. Brain Res. 1973 Sep 14;59:1-18 - PubMed
  45. J Cell Sci. 2004 Jan 1;117(Pt 1):19-29 - PubMed

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