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Yu Z, Li Y, Fan H, et al. miRNAs regulate stem cell self-renewal and differentiation. Front Genet. 2012;3:191doi: 10.3389/fgene.2012.00191.
Yu, Z., Li, Y., Fan, H., Liu, Z., & Pestell, R. G. (2012). miRNAs regulate stem cell self-renewal and differentiation. Frontiers in genetics, 3191. https://doi.org/10.3389/fgene.2012.00191
Yu, Zuoren, et al. "miRNAs regulate stem cell self-renewal and differentiation." Frontiers in genetics vol. 3 (2012): 191. doi: https://doi.org/10.3389/fgene.2012.00191
Yu Z, Li Y, Fan H, Liu Z, Pestell RG. miRNAs regulate stem cell self-renewal and differentiation. Front Genet. 2012 Sep 25;3:191. doi: 10.3389/fgene.2012.00191. eCollection 2012. PMID: 23056008; PMCID: PMC3457037.
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Front Genet. 2012 Sep 25;3:191. doi: 10.3389/fgene.2012.00191. eCollection 2012.

miRNAs regulate stem cell self-renewal and differentiation.

Frontiers in genetics

Zuoren Yu, Yuan Li, Huimin Fan, Zhongmin Liu, Richard G Pestell

Affiliations

  1. Research Center for Translational Medicine, Key Laboratory of Arrhythmia, East Hospital, Tongji University School of Medicine Shanghai, China.

PMID: 23056008 PMCID: PMC3457037 DOI: 10.3389/fgene.2012.00191

Abstract

Stem cells undergo symmetric and asymmetric divisions to generate differentiated cells and more stem cells. The balance between self-renewal and differentiation of stem cells is controlled by transcription factors, epigenetic regulatory networks, and microRNAs (miRNAs). Herein the miRNA involvement in the regulation of stem cell self-renewal and differentiation is summarized. miRNA contribution to malignancy through regulating cancer stem cells is described. In addition, the reciprocal associations between miRNAs and epigenetic modifications in control of stem cell fate are discussed.

Keywords: epigenetic modification; microRNA; self-renewal; stem cell

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