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Zhang C, Tanzi RE. Natural Modulators of Amyloid-Beta Precursor Protein Processing. Curr Alzheimer Res. 2012;
Zhang, C., & Tanzi, R. E. (2012). Natural Modulators of Amyloid-Beta Precursor Protein Processing. Current Alzheimer research, .
Zhang, C, and Tanzi, R E. "Natural Modulators of Amyloid-Beta Precursor Protein Processing." Current Alzheimer research vol. (2012).
Zhang C, Tanzi RE. Natural Modulators of Amyloid-Beta Precursor Protein Processing. Curr Alzheimer Res. 2012 Sep 13; Epub 2012 Sep 13. PMID: 22998566; PMCID: PMC3805747.
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Curr Alzheimer Res. 2012 Sep 13; Epub 2012 Sep 13.

Natural Modulators of Amyloid-Beta Precursor Protein Processing.

Current Alzheimer research

C Zhang, R E Tanzi

Affiliations

  1. Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA, 02129-2060, USA. [email protected].

PMID: 22998566 PMCID: PMC3805747

Abstract

Alzheimer�s disease (AD) is a devastating neurodegenerative disease and the primary cause of dementia, with no cure currently available. The pathogenesis of AD is believed to be primarily driven by Aβ, the principal component of senile plaques. Aβ is an ~4 kDa peptide generated from the amyloid-β precursor protein (APP) through proteolytic secretases. Natural products, particularly those utilized in traditional Chinese medicine (TCM), have a long history alleviating common clinical disorders, including dementia. However, the cell/molecular pathways mediated by these natural products are largely unknown until recently when the underlying molecular mechanisms of the disorders begin to be elucidated. Here, the mechanisms with which natural products modulate the pathogenesis of AD are discussed, in particular, by focusing on their roles in the processing of APP.

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